Thyroid function test evolution in children with Hashimoto’s thyroiditis is closely conditioned by the biochemical picture at diagnosis
Abstract ᅟ Aim of this commentary is to summarize the salient literature views on the relationships between presentation and evolution patterns of thyroid function in children with Hashimoto’s thyroiditis (HT). According to the most recent reports, children with HT and subclinical hypothyroidism (SH...
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| Format: | Article |
| Language: | English |
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BMC
2018-02-01
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| Series: | Italian Journal of Pediatrics |
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| Online Access: | http://link.springer.com/article/10.1186/s13052-018-0461-5 |
| _version_ | 1818896873664020480 |
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| author | Giuseppe Crisafulli Romina Gallizzi Tommaso Aversa Giuseppina Salzano Mariella Valenzise Malgorzata Wasniewska Filippo De Luca Giuseppina Zirilli |
| author_facet | Giuseppe Crisafulli Romina Gallizzi Tommaso Aversa Giuseppina Salzano Mariella Valenzise Malgorzata Wasniewska Filippo De Luca Giuseppina Zirilli |
| author_sort | Giuseppe Crisafulli |
| collection | DOAJ |
| description | Abstract ᅟ Aim of this commentary is to summarize the salient literature views on the relationships between presentation and evolution patterns of thyroid function in children with Hashimoto’s thyroiditis (HT). According to the most recent reports, children with HT and subclinical hypothyroidism (SH) are more prone to the risk of developing severe thyroid dysfunctions over time, if compared to those presenting with euthyroidism. In contrast, children presenting with HT and either overt or subclinical hyperthyroidism are incline to exhibit a definitive resolution of the hyperthyroid phase within some months, although there is a wide variability between the different individuals. The natural history of frank hypothyroidism in the children with HT has never been investigated so far, since in these cases an immediate onset of replacement treatment is mandatory. Conclusions 1) a deterioration of thyroid status over time may be observed especially in the children presenting with SH, but also in those presenting with euthyroidism; 2) a definitive resolution of the hyperthyroid phase is generally observed in those presenting with either overt or subclinical hyperthyroidism. |
| first_indexed | 2024-12-19T19:07:12Z |
| format | Article |
| id | doaj.art-256babfefd444446ae6b660ced7ebbd2 |
| institution | Directory Open Access Journal |
| issn | 1824-7288 |
| language | English |
| last_indexed | 2024-12-19T19:07:12Z |
| publishDate | 2018-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Italian Journal of Pediatrics |
| spelling | doaj.art-256babfefd444446ae6b660ced7ebbd22022-12-21T20:09:25ZengBMCItalian Journal of Pediatrics1824-72882018-02-014411610.1186/s13052-018-0461-5Thyroid function test evolution in children with Hashimoto’s thyroiditis is closely conditioned by the biochemical picture at diagnosisGiuseppe Crisafulli0Romina Gallizzi1Tommaso Aversa2Giuseppina Salzano3Mariella Valenzise4Malgorzata Wasniewska5Filippo De Luca6Giuseppina Zirilli7Department of Human Pathology in Adulthood and Childhood, University of MessinaDepartment of Human Pathology in Adulthood and Childhood, University of MessinaDepartment of Human Pathology in Adulthood and Childhood, University of MessinaDepartment of Human Pathology in Adulthood and Childhood, University of MessinaDepartment of Human Pathology in Adulthood and Childhood, University of MessinaDepartment of Human Pathology in Adulthood and Childhood, University of MessinaDepartment of Human Pathology in Adulthood and Childhood, University of MessinaDepartment of Human Pathology in Adulthood and Childhood, University of MessinaAbstract ᅟ Aim of this commentary is to summarize the salient literature views on the relationships between presentation and evolution patterns of thyroid function in children with Hashimoto’s thyroiditis (HT). According to the most recent reports, children with HT and subclinical hypothyroidism (SH) are more prone to the risk of developing severe thyroid dysfunctions over time, if compared to those presenting with euthyroidism. In contrast, children presenting with HT and either overt or subclinical hyperthyroidism are incline to exhibit a definitive resolution of the hyperthyroid phase within some months, although there is a wide variability between the different individuals. The natural history of frank hypothyroidism in the children with HT has never been investigated so far, since in these cases an immediate onset of replacement treatment is mandatory. Conclusions 1) a deterioration of thyroid status over time may be observed especially in the children presenting with SH, but also in those presenting with euthyroidism; 2) a definitive resolution of the hyperthyroid phase is generally observed in those presenting with either overt or subclinical hyperthyroidism.http://link.springer.com/article/10.1186/s13052-018-0461-5HashitoxicosisOvert hyperthyroidismOvert hypothyroidismSubclinical hyperthyroidismSubclinical hypothyroidismThyroid status natural course |
| spellingShingle | Giuseppe Crisafulli Romina Gallizzi Tommaso Aversa Giuseppina Salzano Mariella Valenzise Malgorzata Wasniewska Filippo De Luca Giuseppina Zirilli Thyroid function test evolution in children with Hashimoto’s thyroiditis is closely conditioned by the biochemical picture at diagnosis Italian Journal of Pediatrics Hashitoxicosis Overt hyperthyroidism Overt hypothyroidism Subclinical hyperthyroidism Subclinical hypothyroidism Thyroid status natural course |
| title | Thyroid function test evolution in children with Hashimoto’s thyroiditis is closely conditioned by the biochemical picture at diagnosis |
| title_full | Thyroid function test evolution in children with Hashimoto’s thyroiditis is closely conditioned by the biochemical picture at diagnosis |
| title_fullStr | Thyroid function test evolution in children with Hashimoto’s thyroiditis is closely conditioned by the biochemical picture at diagnosis |
| title_full_unstemmed | Thyroid function test evolution in children with Hashimoto’s thyroiditis is closely conditioned by the biochemical picture at diagnosis |
| title_short | Thyroid function test evolution in children with Hashimoto’s thyroiditis is closely conditioned by the biochemical picture at diagnosis |
| title_sort | thyroid function test evolution in children with hashimoto s thyroiditis is closely conditioned by the biochemical picture at diagnosis |
| topic | Hashitoxicosis Overt hyperthyroidism Overt hypothyroidism Subclinical hyperthyroidism Subclinical hypothyroidism Thyroid status natural course |
| url | http://link.springer.com/article/10.1186/s13052-018-0461-5 |
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