[PROVISIONAL] Perforin Gene PRF1 c.900C>T Polymorphism and HIV-1 Vertical Transmission

[PROVISIONAL] Perforin Gene PRF1 c.900C>T Polymorphism and HIV-1 Vertical Transmission

Abstract Perforin-1, component of the immune system, is able to control Human Immunodeficiency Virus-1 (HIV-1) replication and it could be involved in HIV-1 mother-to-child transmission (MTCT). This study aims at evaluating the role of c.900C>T PRF1 gene (encoding for perforin-1) polymorphism (rs...

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Bibliographic Details
Main Authors: Luisa Zupin, Vania Polesello, Anselmo Jiro Kamada, Rossella Gratton, Ludovica Segat, Louise Kuhn, Sergio Crovella
Format: Article
Language:English
Published: Sociedade Brasileira de Genética
Series:Genetics and Molecular Biology
Subjects:
PRF1
perforin
HIV-1 susceptibility
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572019005019104&lng=en&tlng=en
Description
Summary:Abstract Perforin-1, component of the immune system, is able to control Human Immunodeficiency Virus-1 (HIV-1) replication and it could be involved in HIV-1 mother-to-child transmission (MTCT). This study aims at evaluating the role of c.900C>T PRF1 gene (encoding for perforin-1) polymorphism (rs885822) in HIV-1 MTCT. PRF1 c.900C>T polymorphism was genotyped in 331 children from Zambia using Taqman probe on Real Time PCR platform. PRF1 c.900C>T C/T genotype was more frequent amongst HIV-1 exposed but non-infected children than in HIV-1 positive cases and the results were confirmed among children infected during breastfeeding. PRF1 c.900C>T correlated with protection against HIV-1 MTCT, suggesting its role in HIV-1 vertical transmission.
ISSN:1678-4685

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