[PROVISIONAL] Perforin Gene PRF1 c.900C>T Polymorphism and HIV-1 Vertical Transmission
Abstract Perforin-1, component of the immune system, is able to control Human Immunodeficiency Virus-1 (HIV-1) replication and it could be involved in HIV-1 mother-to-child transmission (MTCT). This study aims at evaluating the role of c.900C>T PRF1 gene (encoding for perforin-1) polymorphism (rs...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Genética
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| Series: | Genetics and Molecular Biology |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572019005019104&lng=en&tlng=en |
| _version_ | 1818300574329733120 |
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| author | Luisa Zupin Vania Polesello Anselmo Jiro Kamada Rossella Gratton Ludovica Segat Louise Kuhn Sergio Crovella |
| author_facet | Luisa Zupin Vania Polesello Anselmo Jiro Kamada Rossella Gratton Ludovica Segat Louise Kuhn Sergio Crovella |
| author_sort | Luisa Zupin |
| collection | DOAJ |
| description | Abstract Perforin-1, component of the immune system, is able to control Human Immunodeficiency Virus-1 (HIV-1) replication and it could be involved in HIV-1 mother-to-child transmission (MTCT). This study aims at evaluating the role of c.900C>T PRF1 gene (encoding for perforin-1) polymorphism (rs885822) in HIV-1 MTCT. PRF1 c.900C>T polymorphism was genotyped in 331 children from Zambia using Taqman probe on Real Time PCR platform. PRF1 c.900C>T C/T genotype was more frequent amongst HIV-1 exposed but non-infected children than in HIV-1 positive cases and the results were confirmed among children infected during breastfeeding. PRF1 c.900C>T correlated with protection against HIV-1 MTCT, suggesting its role in HIV-1 vertical transmission. |
| first_indexed | 2024-12-13T05:09:17Z |
| format | Article |
| id | doaj.art-256d5563403047c0aca3552880ff55c7 |
| institution | Directory Open Access Journal |
| issn | 1678-4685 |
| language | English |
| last_indexed | 2024-12-13T05:09:17Z |
| publisher | Sociedade Brasileira de Genética |
| record_format | Article |
| series | Genetics and Molecular Biology |
| spelling | doaj.art-256d5563403047c0aca3552880ff55c72022-12-21T23:58:34ZengSociedade Brasileira de GenéticaGenetics and Molecular Biology1678-4685010.1590/1678-4685-gmb-2018-0243S1415-47572019005019104[PROVISIONAL] Perforin Gene PRF1 c.900C>T Polymorphism and HIV-1 Vertical TransmissionLuisa ZupinVania PoleselloAnselmo Jiro KamadaRossella GrattonLudovica SegatLouise KuhnSergio CrovellaAbstract Perforin-1, component of the immune system, is able to control Human Immunodeficiency Virus-1 (HIV-1) replication and it could be involved in HIV-1 mother-to-child transmission (MTCT). This study aims at evaluating the role of c.900C>T PRF1 gene (encoding for perforin-1) polymorphism (rs885822) in HIV-1 MTCT. PRF1 c.900C>T polymorphism was genotyped in 331 children from Zambia using Taqman probe on Real Time PCR platform. PRF1 c.900C>T C/T genotype was more frequent amongst HIV-1 exposed but non-infected children than in HIV-1 positive cases and the results were confirmed among children infected during breastfeeding. PRF1 c.900C>T correlated with protection against HIV-1 MTCT, suggesting its role in HIV-1 vertical transmission.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572019005019104&lng=en&tlng=enPRF1perforinHIV-1 susceptibility |
| spellingShingle | Luisa Zupin Vania Polesello Anselmo Jiro Kamada Rossella Gratton Ludovica Segat Louise Kuhn Sergio Crovella [PROVISIONAL] Perforin Gene PRF1 c.900C>T Polymorphism and HIV-1 Vertical Transmission Genetics and Molecular Biology PRF1 perforin HIV-1 susceptibility |
| title | [PROVISIONAL] Perforin Gene PRF1 c.900C>T Polymorphism and HIV-1 Vertical Transmission |
| title_full | [PROVISIONAL] Perforin Gene PRF1 c.900C>T Polymorphism and HIV-1 Vertical Transmission |
| title_fullStr | [PROVISIONAL] Perforin Gene PRF1 c.900C>T Polymorphism and HIV-1 Vertical Transmission |
| title_full_unstemmed | [PROVISIONAL] Perforin Gene PRF1 c.900C>T Polymorphism and HIV-1 Vertical Transmission |
| title_short | [PROVISIONAL] Perforin Gene PRF1 c.900C>T Polymorphism and HIV-1 Vertical Transmission |
| title_sort | provisional perforin gene prf1 c 900c t polymorphism and hiv 1 vertical transmission |
| topic | PRF1 perforin HIV-1 susceptibility |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572019005019104&lng=en&tlng=en |
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