Cancer stem cell, chromosomal instability, and cancer immunity
Cancer stem cells (CSCs) are a unique population of tumor cells with stem cell-like properties. They are believed to be involved in drug resistance, potential therapy failure, tumor relapse after treatment, and ultimately reduced overall survival of cancer patients. One of the causal factors that ma...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Open Exploration Publishing Inc.
2024-04-01
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| Series: | Exploration of Immunology |
| Subjects: | |
| Online Access: | https://www.explorationpub.com/Journals/ei/Article/1003135 |
| _version_ | 1797201098269786112 |
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| author | Laxmi Kumari Saloni Munjal Reena Yadav Yashwant Kumar Alka Bhatia |
| author_facet | Laxmi Kumari Saloni Munjal Reena Yadav Yashwant Kumar Alka Bhatia |
| author_sort | Laxmi Kumari |
| collection | DOAJ |
| description | Cancer stem cells (CSCs) are a unique population of tumor cells with stem cell-like properties. They are believed to be involved in drug resistance, potential therapy failure, tumor relapse after treatment, and ultimately reduced overall survival of cancer patients. One of the causal factors that may lead to CSC formation is chromosomal instability (CIN), a dynamic event leading to numerical and structural changes in the chromosomes. The CIN is also proposed to aid the maintenance of CSCs, contribute towards their heterogeneity, and facilitate their immune escape. However, the role of CIN in the modulation of the immune system in tumors remains contradictory. Studies have revealed that it can lead to both activation and suppression of the immune system. Previous literature suggests that the CIN, CSCs, and cancer immunity (3Cs), interact with and complement each other to create a pro-tumor environment. However, the mechanisms underlying such an interaction are poorly understood. So, in this review article, an attempt has been made to understand the nature of the interaction between the triad of CIN, CSC, and the immune response in tumors and some of the pathways governing the same. Understanding the above may be a positive step towards the complete cure for malignant diseases. |
| first_indexed | 2024-04-24T07:42:08Z |
| format | Article |
| id | doaj.art-256f8005569444ac91ab15fbb969f17a |
| institution | Directory Open Access Journal |
| issn | 2768-6655 |
| language | English |
| last_indexed | 2024-04-24T07:42:08Z |
| publishDate | 2024-04-01 |
| publisher | Open Exploration Publishing Inc. |
| record_format | Article |
| series | Exploration of Immunology |
| spelling | doaj.art-256f8005569444ac91ab15fbb969f17a2024-04-19T09:13:21ZengOpen Exploration Publishing Inc.Exploration of Immunology2768-66552024-04-014216918810.37349/ei.2024.00135Cancer stem cell, chromosomal instability, and cancer immunityLaxmi Kumari0Saloni Munjal1Reena Yadav2Yashwant Kumar3Alka Bhatia4https://orcid.org/0000-0002-7976-0824Department of Experimental Medicine and Biotechnology, Post Graduate Institute of Medical Education & Research, Chandigarh 160012, IndiaDepartment of Experimental Medicine and Biotechnology, Post Graduate Institute of Medical Education & Research, Chandigarh 160012, IndiaDepartment of Experimental Medicine and Biotechnology, Post Graduate Institute of Medical Education & Research, Chandigarh 160012, IndiaDepartment of Immunopathology, Post Graduate Institute of Medical Education & Research, Chandigarh 160012, IndiaDepartment of Experimental Medicine and Biotechnology, Post Graduate Institute of Medical Education & Research, Chandigarh 160012, IndiaCancer stem cells (CSCs) are a unique population of tumor cells with stem cell-like properties. They are believed to be involved in drug resistance, potential therapy failure, tumor relapse after treatment, and ultimately reduced overall survival of cancer patients. One of the causal factors that may lead to CSC formation is chromosomal instability (CIN), a dynamic event leading to numerical and structural changes in the chromosomes. The CIN is also proposed to aid the maintenance of CSCs, contribute towards their heterogeneity, and facilitate their immune escape. However, the role of CIN in the modulation of the immune system in tumors remains contradictory. Studies have revealed that it can lead to both activation and suppression of the immune system. Previous literature suggests that the CIN, CSCs, and cancer immunity (3Cs), interact with and complement each other to create a pro-tumor environment. However, the mechanisms underlying such an interaction are poorly understood. So, in this review article, an attempt has been made to understand the nature of the interaction between the triad of CIN, CSC, and the immune response in tumors and some of the pathways governing the same. Understanding the above may be a positive step towards the complete cure for malignant diseases.https://www.explorationpub.com/Journals/ei/Article/1003135cancer stem cellschromosomal instabilitystem cellsimmune systemnon-stem cancer cellsextracellular matrix |
| spellingShingle | Laxmi Kumari Saloni Munjal Reena Yadav Yashwant Kumar Alka Bhatia Cancer stem cell, chromosomal instability, and cancer immunity Exploration of Immunology cancer stem cells chromosomal instability stem cells immune system non-stem cancer cells extracellular matrix |
| title | Cancer stem cell, chromosomal instability, and cancer immunity |
| title_full | Cancer stem cell, chromosomal instability, and cancer immunity |
| title_fullStr | Cancer stem cell, chromosomal instability, and cancer immunity |
| title_full_unstemmed | Cancer stem cell, chromosomal instability, and cancer immunity |
| title_short | Cancer stem cell, chromosomal instability, and cancer immunity |
| title_sort | cancer stem cell chromosomal instability and cancer immunity |
| topic | cancer stem cells chromosomal instability stem cells immune system non-stem cancer cells extracellular matrix |
| url | https://www.explorationpub.com/Journals/ei/Article/1003135 |
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