Cytotoxic CD8+ T cells target citrullinated antigens in rheumatoid arthritis
The immune mechanisms underlying synovitis and joint tissue destruction in rheumatoid arthritis (RA) remain incompletely defined. Here, the authors demonstrate that ACPA+ RA patients have activated clonally expanded cytotoxic GZMB+ CD8+ T cells in blood and synovium that target and are activated by...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-35264-8 |
| _version_ | 1827983316270186496 |
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| author | Jae-Seung Moon Shady Younis Nitya S. Ramadoss Radhika Iyer Khushboo Sheth Orr Sharpe Navin L. Rao Stephane Becart Julie A. Carman Eddie A. James Jane H. Buckner Kevin D. Deane V. Michael Holers Susan M. Goodman Laura T. Donlin Mark M. Davis William H. Robinson |
| author_facet | Jae-Seung Moon Shady Younis Nitya S. Ramadoss Radhika Iyer Khushboo Sheth Orr Sharpe Navin L. Rao Stephane Becart Julie A. Carman Eddie A. James Jane H. Buckner Kevin D. Deane V. Michael Holers Susan M. Goodman Laura T. Donlin Mark M. Davis William H. Robinson |
| author_sort | Jae-Seung Moon |
| collection | DOAJ |
| description | The immune mechanisms underlying synovitis and joint tissue destruction in rheumatoid arthritis (RA) remain incompletely defined. Here, the authors demonstrate that ACPA+ RA patients have activated clonally expanded cytotoxic GZMB+ CD8+ T cells in blood and synovium that target and are activated by citrullinated antigens to mediate cell killing. |
| first_indexed | 2024-04-09T22:46:43Z |
| format | Article |
| id | doaj.art-256fdecef1e149f1a62547c63372d7f7 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-09T22:46:43Z |
| publishDate | 2023-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-256fdecef1e149f1a62547c63372d7f72023-03-22T11:48:08ZengNature PortfolioNature Communications2041-17232023-01-0114111510.1038/s41467-022-35264-8Cytotoxic CD8+ T cells target citrullinated antigens in rheumatoid arthritisJae-Seung Moon0Shady Younis1Nitya S. Ramadoss2Radhika Iyer3Khushboo Sheth4Orr Sharpe5Navin L. Rao6Stephane Becart7Julie A. Carman8Eddie A. James9Jane H. Buckner10Kevin D. Deane11V. Michael Holers12Susan M. Goodman13Laura T. Donlin14Mark M. Davis15William H. Robinson16Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of MedicineDivision of Immunology and Rheumatology, Department of Medicine, Stanford University School of MedicineDivision of Immunology and Rheumatology, Department of Medicine, Stanford University School of MedicineDivision of Immunology and Rheumatology, Department of Medicine, Stanford University School of MedicineDivision of Immunology and Rheumatology, Department of Medicine, Stanford University School of MedicineDivision of Immunology and Rheumatology, Department of Medicine, Stanford University School of MedicineImmunology Discovery, Janssen Research and Development LLCImmunology Discovery, Janssen Research and Development LLCImmunology Discovery, Janssen Research and Development LLCCenter for Translational Immunology, Benaroya Research InstituteCenter for Translational Immunology, Benaroya Research InstituteDivision of Rheumatology, University of Colorado Anschutz Medical CampusDivision of Rheumatology, University of Colorado Anschutz Medical CampusHospital for Special SurgeryHospital for Special SurgeryInstitute for Immunity, Transplantation and Infection, Stanford UniversityDivision of Immunology and Rheumatology, Department of Medicine, Stanford University School of MedicineThe immune mechanisms underlying synovitis and joint tissue destruction in rheumatoid arthritis (RA) remain incompletely defined. Here, the authors demonstrate that ACPA+ RA patients have activated clonally expanded cytotoxic GZMB+ CD8+ T cells in blood and synovium that target and are activated by citrullinated antigens to mediate cell killing.https://doi.org/10.1038/s41467-022-35264-8 |
| spellingShingle | Jae-Seung Moon Shady Younis Nitya S. Ramadoss Radhika Iyer Khushboo Sheth Orr Sharpe Navin L. Rao Stephane Becart Julie A. Carman Eddie A. James Jane H. Buckner Kevin D. Deane V. Michael Holers Susan M. Goodman Laura T. Donlin Mark M. Davis William H. Robinson Cytotoxic CD8+ T cells target citrullinated antigens in rheumatoid arthritis Nature Communications |
| title | Cytotoxic CD8+ T cells target citrullinated antigens in rheumatoid arthritis |
| title_full | Cytotoxic CD8+ T cells target citrullinated antigens in rheumatoid arthritis |
| title_fullStr | Cytotoxic CD8+ T cells target citrullinated antigens in rheumatoid arthritis |
| title_full_unstemmed | Cytotoxic CD8+ T cells target citrullinated antigens in rheumatoid arthritis |
| title_short | Cytotoxic CD8+ T cells target citrullinated antigens in rheumatoid arthritis |
| title_sort | cytotoxic cd8 t cells target citrullinated antigens in rheumatoid arthritis |
| url | https://doi.org/10.1038/s41467-022-35264-8 |
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