Functional changes in the auditory cortex and associated regions caused by different acoustic stimuli in patients with presbycusis and tinnitus
Presbycusis and tinnitus are the two most common hearing related pathologies. Although both of these conditions presumably originate in the inner ear, there are several reports concerning their central components. Interestingly, the onset of presbycusis coincides with the highest occurrence of tinni...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-10-01
|
| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2022.921873/full |
| _version_ | 1798030982648954880 |
|---|---|
| author | Jakub Fuksa Jakub Fuksa Oliver Profant Oliver Profant Jaroslav Tintěra Veronika Svobodová Veronika Svobodová Diana Tóthová Diana Tóthová Antonin Škoch Josef Syka |
| author_facet | Jakub Fuksa Jakub Fuksa Oliver Profant Oliver Profant Jaroslav Tintěra Veronika Svobodová Veronika Svobodová Diana Tóthová Diana Tóthová Antonin Škoch Josef Syka |
| author_sort | Jakub Fuksa |
| collection | DOAJ |
| description | Presbycusis and tinnitus are the two most common hearing related pathologies. Although both of these conditions presumably originate in the inner ear, there are several reports concerning their central components. Interestingly, the onset of presbycusis coincides with the highest occurrence of tinnitus. The aim of this study was to identify age, hearing loss, and tinnitus related functional changes, within the auditory system and its associated structures. Seventy-eight participants were selected for the study based on their age, hearing, and tinnitus, and they were divided into six groups: young controls (Y-NH-NT), subjects with mild presbycusis (O-NH-NT) or expressed presbycusis (O-HL-NT), young subjects with tinnitus (Y-NH-T), subjects with mild presbycusis and tinnitus (O-NH-T), and subjects with expressed presbycusis and tinnitus (O-HL-T). An MRI functional study was performed with a 3T MRI system, using an event related design (different types of acoustic and visual stimulations and their combinations). The amount of activation of the auditory cortices (ACs) was dependent on the complexity of the stimuli; higher complexity resulted in a larger area of the activated cortex. Auditory stimulation produced a slightly greater activation in the elderly, with a negative effect of hearing loss (lower activation). The congruent audiovisual stimulation led to an increased activity within the default mode network, whereas incongruent stimulation led to increased activation of the visual cortex. The presence of tinnitus increased activation of the AC, specifically in the aged population, with a slight prevalence in the left AC. The occurrence of tinnitus was accompanied by increased activity within the insula and hippocampus bilaterally. Overall, we can conclude that expressed presbycusis leads to a lower activation of the AC, compared to the elderly with normal hearing; aging itself leads to increased activity in the right AC. The complexity of acoustic stimuli plays a major role in the activation of the AC, its support by visual stimulation leads to minimal changes within the AC. Tinnitus causes changes in the activity of the limbic system, as well as in the auditory AC, where it is bound to the left hemisphere. |
| first_indexed | 2024-04-11T19:50:01Z |
| format | Article |
| id | doaj.art-2573bc77a00b411da8c68b9c2e2c9979 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-04-11T19:50:01Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-2573bc77a00b411da8c68b9c2e2c99792022-12-22T04:06:20ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2022-10-011610.3389/fnins.2022.921873921873Functional changes in the auditory cortex and associated regions caused by different acoustic stimuli in patients with presbycusis and tinnitusJakub Fuksa0Jakub Fuksa1Oliver Profant2Oliver Profant3Jaroslav Tintěra4Veronika Svobodová5Veronika Svobodová6Diana Tóthová7Diana Tóthová8Antonin Škoch9Josef Syka10Department of Otorhinolaryngology, 3rd Faculty of Medicine, Faculty Hospital Královské Vinohrady, Charles University, Prague, CzechiaDepartment of Auditory Neuroscience, Institute of Experimental Medicine, The Czech Academy of Sciences, Prague, CzechiaDepartment of Otorhinolaryngology, 3rd Faculty of Medicine, Faculty Hospital Královské Vinohrady, Charles University, Prague, CzechiaDepartment of Auditory Neuroscience, Institute of Experimental Medicine, The Czech Academy of Sciences, Prague, CzechiaMR Unit, Institute for Clinical and Experimental Medicine, Prague, CzechiaDepartment of Auditory Neuroscience, Institute of Experimental Medicine, The Czech Academy of Sciences, Prague, CzechiaDepartment of Otorhinolaryngology, Head and Neck Surgery, 1st Faculty of Medicine, Charles University in Prague and University Hospital Motol, Prague, CzechiaDepartment of Auditory Neuroscience, Institute of Experimental Medicine, The Czech Academy of Sciences, Prague, CzechiaDepartment of Otorhinolaryngology, Head and Neck Surgery, 1st Faculty of Medicine, Charles University in Prague and University Hospital Motol, Prague, CzechiaMR Unit, Institute for Clinical and Experimental Medicine, Prague, CzechiaDepartment of Auditory Neuroscience, Institute of Experimental Medicine, The Czech Academy of Sciences, Prague, CzechiaPresbycusis and tinnitus are the two most common hearing related pathologies. Although both of these conditions presumably originate in the inner ear, there are several reports concerning their central components. Interestingly, the onset of presbycusis coincides with the highest occurrence of tinnitus. The aim of this study was to identify age, hearing loss, and tinnitus related functional changes, within the auditory system and its associated structures. Seventy-eight participants were selected for the study based on their age, hearing, and tinnitus, and they were divided into six groups: young controls (Y-NH-NT), subjects with mild presbycusis (O-NH-NT) or expressed presbycusis (O-HL-NT), young subjects with tinnitus (Y-NH-T), subjects with mild presbycusis and tinnitus (O-NH-T), and subjects with expressed presbycusis and tinnitus (O-HL-T). An MRI functional study was performed with a 3T MRI system, using an event related design (different types of acoustic and visual stimulations and their combinations). The amount of activation of the auditory cortices (ACs) was dependent on the complexity of the stimuli; higher complexity resulted in a larger area of the activated cortex. Auditory stimulation produced a slightly greater activation in the elderly, with a negative effect of hearing loss (lower activation). The congruent audiovisual stimulation led to an increased activity within the default mode network, whereas incongruent stimulation led to increased activation of the visual cortex. The presence of tinnitus increased activation of the AC, specifically in the aged population, with a slight prevalence in the left AC. The occurrence of tinnitus was accompanied by increased activity within the insula and hippocampus bilaterally. Overall, we can conclude that expressed presbycusis leads to a lower activation of the AC, compared to the elderly with normal hearing; aging itself leads to increased activity in the right AC. The complexity of acoustic stimuli plays a major role in the activation of the AC, its support by visual stimulation leads to minimal changes within the AC. Tinnitus causes changes in the activity of the limbic system, as well as in the auditory AC, where it is bound to the left hemisphere.https://www.frontiersin.org/articles/10.3389/fnins.2022.921873/fullpresbycusistinnitusauditory systemlimbic systemfunctional MRI |
| spellingShingle | Jakub Fuksa Jakub Fuksa Oliver Profant Oliver Profant Jaroslav Tintěra Veronika Svobodová Veronika Svobodová Diana Tóthová Diana Tóthová Antonin Škoch Josef Syka Functional changes in the auditory cortex and associated regions caused by different acoustic stimuli in patients with presbycusis and tinnitus Frontiers in Neuroscience presbycusis tinnitus auditory system limbic system functional MRI |
| title | Functional changes in the auditory cortex and associated regions caused by different acoustic stimuli in patients with presbycusis and tinnitus |
| title_full | Functional changes in the auditory cortex and associated regions caused by different acoustic stimuli in patients with presbycusis and tinnitus |
| title_fullStr | Functional changes in the auditory cortex and associated regions caused by different acoustic stimuli in patients with presbycusis and tinnitus |
| title_full_unstemmed | Functional changes in the auditory cortex and associated regions caused by different acoustic stimuli in patients with presbycusis and tinnitus |
| title_short | Functional changes in the auditory cortex and associated regions caused by different acoustic stimuli in patients with presbycusis and tinnitus |
| title_sort | functional changes in the auditory cortex and associated regions caused by different acoustic stimuli in patients with presbycusis and tinnitus |
| topic | presbycusis tinnitus auditory system limbic system functional MRI |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2022.921873/full |
| work_keys_str_mv | AT jakubfuksa functionalchangesintheauditorycortexandassociatedregionscausedbydifferentacousticstimuliinpatientswithpresbycusisandtinnitus AT jakubfuksa functionalchangesintheauditorycortexandassociatedregionscausedbydifferentacousticstimuliinpatientswithpresbycusisandtinnitus AT oliverprofant functionalchangesintheauditorycortexandassociatedregionscausedbydifferentacousticstimuliinpatientswithpresbycusisandtinnitus AT oliverprofant functionalchangesintheauditorycortexandassociatedregionscausedbydifferentacousticstimuliinpatientswithpresbycusisandtinnitus AT jaroslavtintera functionalchangesintheauditorycortexandassociatedregionscausedbydifferentacousticstimuliinpatientswithpresbycusisandtinnitus AT veronikasvobodova functionalchangesintheauditorycortexandassociatedregionscausedbydifferentacousticstimuliinpatientswithpresbycusisandtinnitus AT veronikasvobodova functionalchangesintheauditorycortexandassociatedregionscausedbydifferentacousticstimuliinpatientswithpresbycusisandtinnitus AT dianatothova functionalchangesintheauditorycortexandassociatedregionscausedbydifferentacousticstimuliinpatientswithpresbycusisandtinnitus AT dianatothova functionalchangesintheauditorycortexandassociatedregionscausedbydifferentacousticstimuliinpatientswithpresbycusisandtinnitus AT antoninskoch functionalchangesintheauditorycortexandassociatedregionscausedbydifferentacousticstimuliinpatientswithpresbycusisandtinnitus AT josefsyka functionalchangesintheauditorycortexandassociatedregionscausedbydifferentacousticstimuliinpatientswithpresbycusisandtinnitus |