Study Protocol – Metabolic syndrome, vitamin D and bone status in South Asian women living in Auckland, New Zealand: A randomised, placebo-controlled, double-blind vitamin D intervention
<p>Abstract</p> <p>Background</p> <p>The identification of the vitamin D receptor in the endocrine pancreas suggests a role for vitamin D in insulin secretion. There is also some limited evidence that vitamin D influences insulin resistance, and thus the early stages of...
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| Format: | Article |
| Language: | English |
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BMC
2008-07-01
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| Series: | BMC Public Health |
| Online Access: | http://www.biomedcentral.com/1471-2458/8/267 |
| _version_ | 1818807565544325120 |
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| author | Kruger Marlena C Conlon Cathryn Matthys Christophe Stonehouse Welma von Hurst Pamela R Coad Jane |
| author_facet | Kruger Marlena C Conlon Cathryn Matthys Christophe Stonehouse Welma von Hurst Pamela R Coad Jane |
| author_sort | Kruger Marlena C |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>The identification of the vitamin D receptor in the endocrine pancreas suggests a role for vitamin D in insulin secretion. There is also some limited evidence that vitamin D influences insulin resistance, and thus the early stages of the development of type 2 diabetes.</p> <p>Methods</p> <p>Eighty-four women of South Asian origin, living in Auckland, New Zealand, were randomised to receive either a supplement (4000IU 25(OH)D<sub>3 </sub>per day) or a placebo for 6 months. At baseline, all participants were vitamin D deficient (serum 25(OH)D<sub>3 </sub><50 nmol/L), insulin resistant (HOMA-IR > 1.93) and/or hyperinsulinaemic, hyperglycemic or had clinical signs of dislipidaemia. Changes in HOMA-IR, lipids, parathyroid hormone, calcium and bone markers were monitored at 3 months and 6 months.</p> <p>Discussion</p> <p>This randomised, controlled trial will be the first to investigate the effect of vitamin D supplementation on insulin resistance in non-diabetic subjects. It will subsequently contribute to the growing body of evidence about the role of vitamin D in metabolic syndrome.Registered clinical.</p> <p>Trial registration</p> <p>Registered clinical trial – Registration No. ACTRN12607000642482</p> |
| first_indexed | 2024-12-18T19:27:41Z |
| format | Article |
| id | doaj.art-2573e6dc814e4595a3d3fea760a85474 |
| institution | Directory Open Access Journal |
| issn | 1471-2458 |
| language | English |
| last_indexed | 2024-12-18T19:27:41Z |
| publishDate | 2008-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Public Health |
| spelling | doaj.art-2573e6dc814e4595a3d3fea760a854742022-12-21T20:55:48ZengBMCBMC Public Health1471-24582008-07-018126710.1186/1471-2458-8-267Study Protocol – Metabolic syndrome, vitamin D and bone status in South Asian women living in Auckland, New Zealand: A randomised, placebo-controlled, double-blind vitamin D interventionKruger Marlena CConlon CathrynMatthys ChristopheStonehouse Welmavon Hurst Pamela RCoad Jane<p>Abstract</p> <p>Background</p> <p>The identification of the vitamin D receptor in the endocrine pancreas suggests a role for vitamin D in insulin secretion. There is also some limited evidence that vitamin D influences insulin resistance, and thus the early stages of the development of type 2 diabetes.</p> <p>Methods</p> <p>Eighty-four women of South Asian origin, living in Auckland, New Zealand, were randomised to receive either a supplement (4000IU 25(OH)D<sub>3 </sub>per day) or a placebo for 6 months. At baseline, all participants were vitamin D deficient (serum 25(OH)D<sub>3 </sub><50 nmol/L), insulin resistant (HOMA-IR > 1.93) and/or hyperinsulinaemic, hyperglycemic or had clinical signs of dislipidaemia. Changes in HOMA-IR, lipids, parathyroid hormone, calcium and bone markers were monitored at 3 months and 6 months.</p> <p>Discussion</p> <p>This randomised, controlled trial will be the first to investigate the effect of vitamin D supplementation on insulin resistance in non-diabetic subjects. It will subsequently contribute to the growing body of evidence about the role of vitamin D in metabolic syndrome.Registered clinical.</p> <p>Trial registration</p> <p>Registered clinical trial – Registration No. ACTRN12607000642482</p>http://www.biomedcentral.com/1471-2458/8/267 |
| spellingShingle | Kruger Marlena C Conlon Cathryn Matthys Christophe Stonehouse Welma von Hurst Pamela R Coad Jane Study Protocol – Metabolic syndrome, vitamin D and bone status in South Asian women living in Auckland, New Zealand: A randomised, placebo-controlled, double-blind vitamin D intervention BMC Public Health |
| title | Study Protocol – Metabolic syndrome, vitamin D and bone status in South Asian women living in Auckland, New Zealand: A randomised, placebo-controlled, double-blind vitamin D intervention |
| title_full | Study Protocol – Metabolic syndrome, vitamin D and bone status in South Asian women living in Auckland, New Zealand: A randomised, placebo-controlled, double-blind vitamin D intervention |
| title_fullStr | Study Protocol – Metabolic syndrome, vitamin D and bone status in South Asian women living in Auckland, New Zealand: A randomised, placebo-controlled, double-blind vitamin D intervention |
| title_full_unstemmed | Study Protocol – Metabolic syndrome, vitamin D and bone status in South Asian women living in Auckland, New Zealand: A randomised, placebo-controlled, double-blind vitamin D intervention |
| title_short | Study Protocol – Metabolic syndrome, vitamin D and bone status in South Asian women living in Auckland, New Zealand: A randomised, placebo-controlled, double-blind vitamin D intervention |
| title_sort | study protocol metabolic syndrome vitamin d and bone status in south asian women living in auckland new zealand a randomised placebo controlled double blind vitamin d intervention |
| url | http://www.biomedcentral.com/1471-2458/8/267 |
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