DAZL Limits Pluripotency, Differentiation, and Apoptosis in Developing Primordial Germ Cells

DAZL Limits Pluripotency, Differentiation, and Apoptosis in Developing Primordial Germ Cells

The scarcity of primordial germ cells (PGCs) in the developing mammalian embryo hampers robust biochemical analysis of the processes that underlie early germ cell formation. Here, we demonstrate that DAZL, a germ cell-specific RNA binding protein, is a robust PGC marker during in vitro germ cell dev...

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Bibliographic Details
Main Authors: Hsu-Hsin Chen, Maaike Welling, Donald B. Bloch, Javier Muñoz, Edwin Mientjes, Xinjie Chen, Cody Tramp, Jie Wu, Akiko Yabuuchi, Yu-Fen Chou, Christa Buecker, Adrian Krainer, Rob Willemsen, Albert J. Heck, Niels Geijsen
Format: Article
Language:English
Published: Elsevier 2014-11-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671114002884

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