Selective square wave voltammetric determination of tinidazole in pharmaceutical formulations, and human urine samples using poly(bis(2,2′-bipyridine)diresorcinolateruthenium(III) chloride) modified glassy carbon electrode
This study reports the determination of Tinidazole (TDL) using a modified glassy carbon electrode, poly(bis(2,2′-bipyridine)diresorcinateruthenium(III) chloride) (poly(BBPDRRuC)/GCE) by a newly synthesized mixed ligand complex, bis-(2,2′-bipyridine)diresorcinateruthenium(III) chloride(BBPDRRuC). Ele...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-02-01
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| Series: | Sensing and Bio-Sensing Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214180423000594 |
| _version_ | 1797249133483917312 |
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| author | Getasil Chanie Adane Kassa Getinet Tamiru Tigineh Atakilt Abebe |
| author_facet | Getasil Chanie Adane Kassa Getinet Tamiru Tigineh Atakilt Abebe |
| author_sort | Getasil Chanie |
| collection | DOAJ |
| description | This study reports the determination of Tinidazole (TDL) using a modified glassy carbon electrode, poly(bis(2,2′-bipyridine)diresorcinateruthenium(III) chloride) (poly(BBPDRRuC)/GCE) by a newly synthesized mixed ligand complex, bis-(2,2′-bipyridine)diresorcinateruthenium(III) chloride(BBPDRRuC). Electrochemical impedance spectroscopy (EIS) and cyclic voltamettry (CV) results demonstrated modification of the surface of the electrode by a conductive, and electroactive polymer film leading to an enhanced effective electrode surface area and their electrocatalytic role. Appearance of an irreversible reductive peak at much reduced potential with four folds current enhancement at poly(BBPDRRuC)/GCE showed the catalytic effect of the modifier by reduction of TDL. Square wave voltammetry current response of poly(BBPDRRuC)/GCE showed linear dependence on concentration of TDL in the range 10−8˗ 3.0 × 10−4 M with LoD and LoQ of 2.5 nM, and 8.2 nM, respectively. The TDL level in the studied tablet brands were in the range 96.6–101.1% of their labeled values. Spike recovery results in tablet, and human blood serum samples were in the range 98.3˗100.4%, and 98.85 ˗ 99.89%, respectively, and interference recovery results with <4.5% error. The developed method required a simple electrode modification step, a relatively chip, an easily available and non-toxic modifier, provides the least LoD, and reasonably wider linear dynamic range, and had excellent performance for the determination of TDL in tablet formulation and serum samples as compared with recently reported voltammetric methods. |
| first_indexed | 2024-03-08T09:41:29Z |
| format | Article |
| id | doaj.art-2577dcb6d55449b5b769e417d1632d0e |
| institution | Directory Open Access Journal |
| issn | 2214-1804 |
| language | English |
| last_indexed | 2024-04-24T20:25:38Z |
| publishDate | 2024-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Sensing and Bio-Sensing Research |
| spelling | doaj.art-2577dcb6d55449b5b769e417d1632d0e2024-03-22T05:39:40ZengElsevierSensing and Bio-Sensing Research2214-18042024-02-0143100607Selective square wave voltammetric determination of tinidazole in pharmaceutical formulations, and human urine samples using poly(bis(2,2′-bipyridine)diresorcinolateruthenium(III) chloride) modified glassy carbon electrodeGetasil Chanie0Adane Kassa1Getinet Tamiru Tigineh2Atakilt Abebe3Department of Chemistry, College of Science, Bahir Dar University, EthiopiaDepartment of Chemistry, College of Science, Bahir Dar University, Ethiopia; Department of Chemistry, College of Natural and Computational Sciences, Debre Markos University, Ethiopia; Corresponding author at: Department of Chemistry, College of Science, Bahir Dar University, Ethiopia.Department of Chemistry, College of Science, Bahir Dar University, EthiopiaDepartment of Chemistry, College of Science, Bahir Dar University, Ethiopia; Corresponding author.This study reports the determination of Tinidazole (TDL) using a modified glassy carbon electrode, poly(bis(2,2′-bipyridine)diresorcinateruthenium(III) chloride) (poly(BBPDRRuC)/GCE) by a newly synthesized mixed ligand complex, bis-(2,2′-bipyridine)diresorcinateruthenium(III) chloride(BBPDRRuC). Electrochemical impedance spectroscopy (EIS) and cyclic voltamettry (CV) results demonstrated modification of the surface of the electrode by a conductive, and electroactive polymer film leading to an enhanced effective electrode surface area and their electrocatalytic role. Appearance of an irreversible reductive peak at much reduced potential with four folds current enhancement at poly(BBPDRRuC)/GCE showed the catalytic effect of the modifier by reduction of TDL. Square wave voltammetry current response of poly(BBPDRRuC)/GCE showed linear dependence on concentration of TDL in the range 10−8˗ 3.0 × 10−4 M with LoD and LoQ of 2.5 nM, and 8.2 nM, respectively. The TDL level in the studied tablet brands were in the range 96.6–101.1% of their labeled values. Spike recovery results in tablet, and human blood serum samples were in the range 98.3˗100.4%, and 98.85 ˗ 99.89%, respectively, and interference recovery results with <4.5% error. The developed method required a simple electrode modification step, a relatively chip, an easily available and non-toxic modifier, provides the least LoD, and reasonably wider linear dynamic range, and had excellent performance for the determination of TDL in tablet formulation and serum samples as compared with recently reported voltammetric methods.http://www.sciencedirect.com/science/article/pii/S2214180423000594Electrochemical determinationTinidazoleBis(2,2′-bipyridine)diresorcinateruthenium(III) chlorideGlassy carbon electrodeTablet formulations |
| spellingShingle | Getasil Chanie Adane Kassa Getinet Tamiru Tigineh Atakilt Abebe Selective square wave voltammetric determination of tinidazole in pharmaceutical formulations, and human urine samples using poly(bis(2,2′-bipyridine)diresorcinolateruthenium(III) chloride) modified glassy carbon electrode Sensing and Bio-Sensing Research Electrochemical determination Tinidazole Bis(2,2′-bipyridine)diresorcinateruthenium(III) chloride Glassy carbon electrode Tablet formulations |
| title | Selective square wave voltammetric determination of tinidazole in pharmaceutical formulations, and human urine samples using poly(bis(2,2′-bipyridine)diresorcinolateruthenium(III) chloride) modified glassy carbon electrode |
| title_full | Selective square wave voltammetric determination of tinidazole in pharmaceutical formulations, and human urine samples using poly(bis(2,2′-bipyridine)diresorcinolateruthenium(III) chloride) modified glassy carbon electrode |
| title_fullStr | Selective square wave voltammetric determination of tinidazole in pharmaceutical formulations, and human urine samples using poly(bis(2,2′-bipyridine)diresorcinolateruthenium(III) chloride) modified glassy carbon electrode |
| title_full_unstemmed | Selective square wave voltammetric determination of tinidazole in pharmaceutical formulations, and human urine samples using poly(bis(2,2′-bipyridine)diresorcinolateruthenium(III) chloride) modified glassy carbon electrode |
| title_short | Selective square wave voltammetric determination of tinidazole in pharmaceutical formulations, and human urine samples using poly(bis(2,2′-bipyridine)diresorcinolateruthenium(III) chloride) modified glassy carbon electrode |
| title_sort | selective square wave voltammetric determination of tinidazole in pharmaceutical formulations and human urine samples using poly bis 2 2 bipyridine diresorcinolateruthenium iii chloride modified glassy carbon electrode |
| topic | Electrochemical determination Tinidazole Bis(2,2′-bipyridine)diresorcinateruthenium(III) chloride Glassy carbon electrode Tablet formulations |
| url | http://www.sciencedirect.com/science/article/pii/S2214180423000594 |
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