Evaluation of Histomorphological Spectrum of Skin Lesions at a Teaching Institute in Agra: A Cross-sectional Study
Introduction: The skin is the largest organ system in humans. Different skin diseases consist of non specific, non infectious and infectious diseases to various neoplastic lesions. Dermatological lesions are commonly encountered in all countries and it encompasses a wide spectrum, varies from countr...
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JCDR Research and Publications Private Limited
2022-09-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| author | Chandrakanta Pooja Nagayach Lalit Kumar Deepak Rawal Prashant Singh Harendra Kumar Yatendra Chahar |
| author_facet | Chandrakanta Pooja Nagayach Lalit Kumar Deepak Rawal Prashant Singh Harendra Kumar Yatendra Chahar |
| author_sort | Chandrakanta |
| collection | DOAJ |
| description | Introduction: The skin is the largest organ system in humans. Different skin diseases consist of non specific, non infectious and infectious diseases to various neoplastic lesions. Dermatological lesions are commonly encountered in all countries and it encompasses a wide spectrum, varies from country to country and various regions within a country and influenced by sex, age and associated systemic disorders, economy, literacy, racial and social customs. The clinical presentation is restricted to only a few changes such as hyperpigmentation, hypopigmentation, macules, papules, nodules and few others. However, the spectrum of histopathology of skin disorders is varied. Accurate diagnosis of skin disorders is of utmost importance as treatment is varied for different skin disorders presenting with the similar clinical lesions.
Aim: To study histomorphological spectrum and distribution of skin lesions.
Materials and Methods: This hospital-based cross-sectional study was conducted in Department of Pathology in collaboration with Department of Skin and Venereal Diseases, Sarojini Naidu Medical College, Agra, Uttar Pradesh, India, over a period of two years from September 2019 to August 2021. The biopsy sample taken from clinically diagnosed skin lesions sent to histology laboratory in 10% formalin. Sample was fixed in 10% neutral buffered formalin over a period of 12 to 24 hours. Paraffin wax blocks were made and 3-4 micrometer sections were taken and stained with Haematoxylin and Eosin (H&E) stain and histology was studied under microscope. Special stains such as Ziehl-Neelsen (Z-N) stain and Fite stain was done, whenever required. Data was entered in Microsoft Excel excel and descriptive data was obtained.
Results: Out of total 105 cases, the maximum patients were of 21-30 years of age group 30 (28.57%) cases followed by 11-20 years of age group 25 (23.81%) cases with male and female ratio M:F=1.5:1. Out of total 105 cases, the most common site involved was trunk in 42 (40%) cases followed by upper limb in 25 (23.81%) cases. The most common skin lesions were non infectious 70 (66.67%) cases, followed by infectious disease 22 (20.95) cases. In non infectious papulosquamous diseases group found 25 (23.81%) cases followed by vesiculobullous and vesiculopustular diseases group 24 (22.86%) cases. Infectious diseases were seen in 22 (20.95%) cases, out of which bacterial diseases being most common in 19 (18.10%) cases followed by parasitic infection 2 (1.90%) cases.
Conclusion: According to the findings of the present study the majority of skin lesions cases requiring biopsy in developing countries is still psoriasis in non infectious papulosquamous diseases group. Tuberculosis and leprosy in infectious diseases category were being the leading cause of morbidity. |
| first_indexed | 2024-04-10T09:01:54Z |
| format | Article |
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| language | English |
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| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-257895bfb5f244b89bd75c10cbbe465e2023-02-21T11:07:27ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2022-09-01169EC10EC1510.7860/JCDR/2022/56863.16836Evaluation of Histomorphological Spectrum of Skin Lesions at a Teaching Institute in Agra: A Cross-sectional StudyChandrakanta0Pooja Nagayach1Lalit Kumar2Deepak Rawal3Prashant Singh4Harendra Kumar5Yatendra Chahar6Professor, Department of Pathology, Sarojini Naidu Medical College, Agra, Uttar Pradesh, India.Assistant Professor, Department of Pathology, Sarojini Naidu Medical College, Agra, Uttar Pradesh, India.Senior Resident, Department of Pathology, Sarojini Naidu Medical College, Agra, Uttar Pradesh, India.Junior Resident, Department of Pathology, Sarojini Naidu Medical College, Agra, Uttar Pradesh, India.Assistant Professor, Department of Pathology, Sarojini Naidu Medical College Agra, Agra, Uttar Pradesh, India.Professor, Department of Pathology, Sarojini Naidu Medical College, Agra, Uttar Pradesh, India.Assistant Professor, Department of Skin and Venereal disease, Sarojini Naidu Medical College, Agra, Uttar Pradesh, India.Introduction: The skin is the largest organ system in humans. Different skin diseases consist of non specific, non infectious and infectious diseases to various neoplastic lesions. Dermatological lesions are commonly encountered in all countries and it encompasses a wide spectrum, varies from country to country and various regions within a country and influenced by sex, age and associated systemic disorders, economy, literacy, racial and social customs. The clinical presentation is restricted to only a few changes such as hyperpigmentation, hypopigmentation, macules, papules, nodules and few others. However, the spectrum of histopathology of skin disorders is varied. Accurate diagnosis of skin disorders is of utmost importance as treatment is varied for different skin disorders presenting with the similar clinical lesions. Aim: To study histomorphological spectrum and distribution of skin lesions. Materials and Methods: This hospital-based cross-sectional study was conducted in Department of Pathology in collaboration with Department of Skin and Venereal Diseases, Sarojini Naidu Medical College, Agra, Uttar Pradesh, India, over a period of two years from September 2019 to August 2021. The biopsy sample taken from clinically diagnosed skin lesions sent to histology laboratory in 10% formalin. Sample was fixed in 10% neutral buffered formalin over a period of 12 to 24 hours. Paraffin wax blocks were made and 3-4 micrometer sections were taken and stained with Haematoxylin and Eosin (H&E) stain and histology was studied under microscope. Special stains such as Ziehl-Neelsen (Z-N) stain and Fite stain was done, whenever required. Data was entered in Microsoft Excel excel and descriptive data was obtained. Results: Out of total 105 cases, the maximum patients were of 21-30 years of age group 30 (28.57%) cases followed by 11-20 years of age group 25 (23.81%) cases with male and female ratio M:F=1.5:1. Out of total 105 cases, the most common site involved was trunk in 42 (40%) cases followed by upper limb in 25 (23.81%) cases. The most common skin lesions were non infectious 70 (66.67%) cases, followed by infectious disease 22 (20.95) cases. In non infectious papulosquamous diseases group found 25 (23.81%) cases followed by vesiculobullous and vesiculopustular diseases group 24 (22.86%) cases. Infectious diseases were seen in 22 (20.95%) cases, out of which bacterial diseases being most common in 19 (18.10%) cases followed by parasitic infection 2 (1.90%) cases. Conclusion: According to the findings of the present study the majority of skin lesions cases requiring biopsy in developing countries is still psoriasis in non infectious papulosquamous diseases group. Tuberculosis and leprosy in infectious diseases category were being the leading cause of morbidity.https://jcdr.net/articles/PDF/16836/56863_CE(AD)_F(KR)_PF1(RD_SHU_SS)_PFA_NC(RD_KM)_PN(KM).pdfgenodermatosesnon infectiouspapulosquamouspemphigus vulgaristuberculosis |
| spellingShingle | Chandrakanta Pooja Nagayach Lalit Kumar Deepak Rawal Prashant Singh Harendra Kumar Yatendra Chahar Evaluation of Histomorphological Spectrum of Skin Lesions at a Teaching Institute in Agra: A Cross-sectional Study Journal of Clinical and Diagnostic Research genodermatoses non infectious papulosquamous pemphigus vulgaris tuberculosis |
| title | Evaluation of Histomorphological Spectrum of Skin Lesions at a Teaching Institute in Agra: A Cross-sectional Study |
| title_full | Evaluation of Histomorphological Spectrum of Skin Lesions at a Teaching Institute in Agra: A Cross-sectional Study |
| title_fullStr | Evaluation of Histomorphological Spectrum of Skin Lesions at a Teaching Institute in Agra: A Cross-sectional Study |
| title_full_unstemmed | Evaluation of Histomorphological Spectrum of Skin Lesions at a Teaching Institute in Agra: A Cross-sectional Study |
| title_short | Evaluation of Histomorphological Spectrum of Skin Lesions at a Teaching Institute in Agra: A Cross-sectional Study |
| title_sort | evaluation of histomorphological spectrum of skin lesions at a teaching institute in agra a cross sectional study |
| topic | genodermatoses non infectious papulosquamous pemphigus vulgaris tuberculosis |
| url | https://jcdr.net/articles/PDF/16836/56863_CE(AD)_F(KR)_PF1(RD_SHU_SS)_PFA_NC(RD_KM)_PN(KM).pdf |
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