Transplacental Transfer of Maternal Antibody against SARS-CoV-2 and Its Influencing Factors: A Review
Since the beginning of the coronavirus disease 2019 (COVID-19) outbreak, the disease has rapidly become a global threat. The constant emergence of new variants has increased the difficulty of controlling this disease. Vaccination is still considered the most effective method to prevent COVID-19. Vac...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/10/7/1083 |
| _version_ | 1797443277155205120 |
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| author | Shuang Liu Jiayi Zhong Dingmei Zhang |
| author_facet | Shuang Liu Jiayi Zhong Dingmei Zhang |
| author_sort | Shuang Liu |
| collection | DOAJ |
| description | Since the beginning of the coronavirus disease 2019 (COVID-19) outbreak, the disease has rapidly become a global threat. The constant emergence of new variants has increased the difficulty of controlling this disease. Vaccination is still considered the most effective method to prevent COVID-19. Vaccination has expanded to include children aged 3–17 years old, and some countries have lowered the age of vaccination to 6 months (for example, the United States). However, children under 3 years old are still not able to be vaccinated in most countries. In this study, we summarize the COVID-19 vaccination status in pregnant women, comprehensively elaborate on the status of maternal immune response and maternal antibody transfer after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and vaccination, and further analyze the possible influencing factors of maternal antibody transfer according to the currently available evidence on the topic. It was concluded that pregnant women develop an immune response and produce antibodies that can be transmitted through the placenta after vaccination, but more data are needed to determine the transfer rate and duration of these maternal antibodies and potential factors. The results provide a scientific basis for studying the protective effect of maternal antibodies on infants, formulating a vaccination strategy for pregnant women, and preventing SARS-CoV-2 infection in infants. |
| first_indexed | 2024-03-09T12:53:37Z |
| format | Article |
| id | doaj.art-257979cdabdd4252a8a9cf75b24bbec7 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-09T12:53:37Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-257979cdabdd4252a8a9cf75b24bbec72023-11-30T22:02:54ZengMDPI AGVaccines2076-393X2022-07-01107108310.3390/vaccines10071083Transplacental Transfer of Maternal Antibody against SARS-CoV-2 and Its Influencing Factors: A ReviewShuang Liu0Jiayi Zhong1Dingmei Zhang2Department of Epidemiology, School of Public Health, Sun Yat-Sen University, Guangzhou 510080, ChinaDepartment of Epidemiology, School of Public Health, Sun Yat-Sen University, Guangzhou 510080, ChinaDepartment of Epidemiology, School of Public Health, Sun Yat-Sen University, Guangzhou 510080, ChinaSince the beginning of the coronavirus disease 2019 (COVID-19) outbreak, the disease has rapidly become a global threat. The constant emergence of new variants has increased the difficulty of controlling this disease. Vaccination is still considered the most effective method to prevent COVID-19. Vaccination has expanded to include children aged 3–17 years old, and some countries have lowered the age of vaccination to 6 months (for example, the United States). However, children under 3 years old are still not able to be vaccinated in most countries. In this study, we summarize the COVID-19 vaccination status in pregnant women, comprehensively elaborate on the status of maternal immune response and maternal antibody transfer after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and vaccination, and further analyze the possible influencing factors of maternal antibody transfer according to the currently available evidence on the topic. It was concluded that pregnant women develop an immune response and produce antibodies that can be transmitted through the placenta after vaccination, but more data are needed to determine the transfer rate and duration of these maternal antibodies and potential factors. The results provide a scientific basis for studying the protective effect of maternal antibodies on infants, formulating a vaccination strategy for pregnant women, and preventing SARS-CoV-2 infection in infants.https://www.mdpi.com/2076-393X/10/7/1083COVID-19 vaccinepregnancymaternal antibodyantibodies transfer |
| spellingShingle | Shuang Liu Jiayi Zhong Dingmei Zhang Transplacental Transfer of Maternal Antibody against SARS-CoV-2 and Its Influencing Factors: A Review Vaccines COVID-19 vaccine pregnancy maternal antibody antibodies transfer |
| title | Transplacental Transfer of Maternal Antibody against SARS-CoV-2 and Its Influencing Factors: A Review |
| title_full | Transplacental Transfer of Maternal Antibody against SARS-CoV-2 and Its Influencing Factors: A Review |
| title_fullStr | Transplacental Transfer of Maternal Antibody against SARS-CoV-2 and Its Influencing Factors: A Review |
| title_full_unstemmed | Transplacental Transfer of Maternal Antibody against SARS-CoV-2 and Its Influencing Factors: A Review |
| title_short | Transplacental Transfer of Maternal Antibody against SARS-CoV-2 and Its Influencing Factors: A Review |
| title_sort | transplacental transfer of maternal antibody against sars cov 2 and its influencing factors a review |
| topic | COVID-19 vaccine pregnancy maternal antibody antibodies transfer |
| url | https://www.mdpi.com/2076-393X/10/7/1083 |
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