Chikungunya patient transcriptional signatures faithfully recapitulated in a C57BL/6J mouse model

Chikungunya patient transcriptional signatures faithfully recapitulated in a C57BL/6J mouse model

IntroductionAn adult wild-type C57BL/6J mouse model of chikungunya virus (CHIKV) infection and disease has been extensively used to study the alphaviral arthritic immunopathology and to evaluate new interventions. How well mouse models recapitulate the gene expression profiles seen in humans remain...

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Bibliographic Details
Main Authors:	Cameron R. Bishop, Felipe Ten Caten, Helder I. Nakaya, Andreas Suhrbier
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-12-01
Series:	Frontiers in Immunology
Subjects:	Chikungunya C57BL/6J mouse model RNA-seq bioinformatics arthritis
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.1092370/full

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