Diabetes is an independent predictor of survival 17 years after myocardial infarction: follow-up of the TRACE registry
<p>Abstract</p> <p>Background</p> <p>In patients hospitalized for myocardial infarction, there are limited data examining the long-term prognostic effect of diabetes.</p> <p>The aim of this study was to systematically evaluate the development of diabetes as...
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| Format: | Article |
| Language: | English |
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BMC
2010-06-01
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| Series: | Cardiovascular Diabetology |
| Online Access: | http://www.cardiab.com/content/9/1/22 |
| _version_ | 1819138342894174208 |
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| author | Torp-Pedersen Christian Køber Lars Gislason Gunnar H Kümler Thomas |
| author_facet | Torp-Pedersen Christian Køber Lars Gislason Gunnar H Kümler Thomas |
| author_sort | Torp-Pedersen Christian |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>In patients hospitalized for myocardial infarction, there are limited data examining the long-term prognostic effect of diabetes.</p> <p>The aim of this study was to systematically evaluate the development of diabetes as an independent long-term prognostic factor after myocardial infarction.</p> <p>Methods</p> <p>Prospective follow-up of 6676 consecutive MI patients screened for entry in the Trandolapril Cardiac Evaluation (TRACE) study. The patients were analysed by Kaplan-Meier survival analysis, landmark analysis and Cox proportional hazard models and outcome measure was all-cause mortality.</p> <p>Results</p> <p>The mortality in patients with diabetes was 82,7% at 10 years of follow-up and 91,1% at 15 years of follow-up, while patients without diabetes had a mortality of 60,2% at 10 years of follow-up and 72,9% at 15 years of follow-up (p < 0.0001). Landmark analysis continued to show prognostic significance of diabetes throughout the duration of follow-up. Multivariable Cox proportional-hazards model showed that the hazard ratio for death in patients with diabetes overall was 1.47 (95% confidence intervals (CI) 1.35-1.61) and varied between 1.19 (CI 1.04-1.37) and 2.13 (CI 1.33-3.42) in the 2-year periods of follow-up.</p> <p>Conclusions</p> <p>Diabetes is an important independent long-term prognostic factor after MI and continues to predict mortality even 17 years after index MI.</p> <p>This underscores the importance of aggressive diagnostic and therapeutic approach in diabetes patients with MI.</p> |
| first_indexed | 2024-12-22T11:05:15Z |
| format | Article |
| id | doaj.art-257c6b710b8148d0b7e0e5d03a26a2d7 |
| institution | Directory Open Access Journal |
| issn | 1475-2840 |
| language | English |
| last_indexed | 2024-12-22T11:05:15Z |
| publishDate | 2010-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Cardiovascular Diabetology |
| spelling | doaj.art-257c6b710b8148d0b7e0e5d03a26a2d72022-12-21T18:28:20ZengBMCCardiovascular Diabetology1475-28402010-06-01912210.1186/1475-2840-9-22Diabetes is an independent predictor of survival 17 years after myocardial infarction: follow-up of the TRACE registryTorp-Pedersen ChristianKøber LarsGislason Gunnar HKümler Thomas<p>Abstract</p> <p>Background</p> <p>In patients hospitalized for myocardial infarction, there are limited data examining the long-term prognostic effect of diabetes.</p> <p>The aim of this study was to systematically evaluate the development of diabetes as an independent long-term prognostic factor after myocardial infarction.</p> <p>Methods</p> <p>Prospective follow-up of 6676 consecutive MI patients screened for entry in the Trandolapril Cardiac Evaluation (TRACE) study. The patients were analysed by Kaplan-Meier survival analysis, landmark analysis and Cox proportional hazard models and outcome measure was all-cause mortality.</p> <p>Results</p> <p>The mortality in patients with diabetes was 82,7% at 10 years of follow-up and 91,1% at 15 years of follow-up, while patients without diabetes had a mortality of 60,2% at 10 years of follow-up and 72,9% at 15 years of follow-up (p < 0.0001). Landmark analysis continued to show prognostic significance of diabetes throughout the duration of follow-up. Multivariable Cox proportional-hazards model showed that the hazard ratio for death in patients with diabetes overall was 1.47 (95% confidence intervals (CI) 1.35-1.61) and varied between 1.19 (CI 1.04-1.37) and 2.13 (CI 1.33-3.42) in the 2-year periods of follow-up.</p> <p>Conclusions</p> <p>Diabetes is an important independent long-term prognostic factor after MI and continues to predict mortality even 17 years after index MI.</p> <p>This underscores the importance of aggressive diagnostic and therapeutic approach in diabetes patients with MI.</p>http://www.cardiab.com/content/9/1/22 |
| spellingShingle | Torp-Pedersen Christian Køber Lars Gislason Gunnar H Kümler Thomas Diabetes is an independent predictor of survival 17 years after myocardial infarction: follow-up of the TRACE registry Cardiovascular Diabetology |
| title | Diabetes is an independent predictor of survival 17 years after myocardial infarction: follow-up of the TRACE registry |
| title_full | Diabetes is an independent predictor of survival 17 years after myocardial infarction: follow-up of the TRACE registry |
| title_fullStr | Diabetes is an independent predictor of survival 17 years after myocardial infarction: follow-up of the TRACE registry |
| title_full_unstemmed | Diabetes is an independent predictor of survival 17 years after myocardial infarction: follow-up of the TRACE registry |
| title_short | Diabetes is an independent predictor of survival 17 years after myocardial infarction: follow-up of the TRACE registry |
| title_sort | diabetes is an independent predictor of survival 17 years after myocardial infarction follow up of the trace registry |
| url | http://www.cardiab.com/content/9/1/22 |
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