An Analysis of Adherence to Vaccination Recommendations in a Thoracic Organ Transplant Cohort
(1) Background: Vaccination of solid organ transplant (SOT) candidates and recipients is vital to decrease infection-related morbidity and mortality. Here we describe our heart and lung transplant programs’ rates of completion of hepatitis B and pneumococcal vaccinations and identify potential oppor...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-10-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/8/4/622 |
| _version_ | 1827703754205429760 |
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| author | Deeksha Jandhyala Jessica D. Lewis |
| author_facet | Deeksha Jandhyala Jessica D. Lewis |
| author_sort | Deeksha Jandhyala |
| collection | DOAJ |
| description | (1) Background: Vaccination of solid organ transplant (SOT) candidates and recipients is vital to decrease infection-related morbidity and mortality. Here we describe our heart and lung transplant programs’ rates of completion of hepatitis B and pneumococcal vaccinations and identify potential opportunities for improvement. (2) Methods: This is a single-center retrospective study that included all heart and lung transplant recipients between 1 July 2013 and 31 July 2018. We assessed demographics, causes of organ failure, pretransplant hepatitis B immune status, and completion rates for hepatitis B vaccine series, pneumococcal conjugate vaccine (PCV13), and pneumococcal polysaccharide vaccine (PPSV23). (3) Results: A total of 41 patients were included in the heart transplant cohort. Twelve (29.3%) had baseline hepatitis B immunity. Only 8/29 (27.6%) completed the entire 3-dose hepatitis B vaccination series pretransplant. Pretransplant PCV13 and PPSV23 vaccination rates were 58.5% (24/41) and 48.8% (20/41), respectively; no additional patients received PCV13 or PPSV23 post-transplant. In the heart transplant cohort, a majority (82.9%) of patients were evaluated by the Transplant Infectious Diseases consultative service (TxID) pretransplant, and this had a statistically significant association with increased pneumococcal vaccination rates (<i>p</i> = 0.0017, PCV13 and <i>p</i> = 0.0103, PPSV23). In total, 55 patients were included in the lung transplant cohort. Five (9.1%) had baseline hepatitis B immunity; 33/50 (66.0%) completed the hepatitis B vaccine series in the pretransplant setting. Pretransplant PCV13 and PPSV23 vaccination rate was 40.0% (22/55) and 69.1% (38/55), respectively. There was only a 47.3% and 72.3% completion rate overall in the post-transplant setting. (4) Conclusions: There continues to be a need for a comprehensive and coordinated effort to increase vaccine adherence for all SOT candidates in the pretransplant setting. |
| first_indexed | 2024-03-10T15:25:21Z |
| format | Article |
| id | doaj.art-257d20b7499f43ecbb7cd4616ef1cc24 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-10T15:25:21Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-257d20b7499f43ecbb7cd4616ef1cc242023-11-20T18:06:46ZengMDPI AGVaccines2076-393X2020-10-018462210.3390/vaccines8040622An Analysis of Adherence to Vaccination Recommendations in a Thoracic Organ Transplant CohortDeeksha Jandhyala0Jessica D. Lewis1Division of Infectious Diseases, Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USADivision of Infectious Diseases, Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA(1) Background: Vaccination of solid organ transplant (SOT) candidates and recipients is vital to decrease infection-related morbidity and mortality. Here we describe our heart and lung transplant programs’ rates of completion of hepatitis B and pneumococcal vaccinations and identify potential opportunities for improvement. (2) Methods: This is a single-center retrospective study that included all heart and lung transplant recipients between 1 July 2013 and 31 July 2018. We assessed demographics, causes of organ failure, pretransplant hepatitis B immune status, and completion rates for hepatitis B vaccine series, pneumococcal conjugate vaccine (PCV13), and pneumococcal polysaccharide vaccine (PPSV23). (3) Results: A total of 41 patients were included in the heart transplant cohort. Twelve (29.3%) had baseline hepatitis B immunity. Only 8/29 (27.6%) completed the entire 3-dose hepatitis B vaccination series pretransplant. Pretransplant PCV13 and PPSV23 vaccination rates were 58.5% (24/41) and 48.8% (20/41), respectively; no additional patients received PCV13 or PPSV23 post-transplant. In the heart transplant cohort, a majority (82.9%) of patients were evaluated by the Transplant Infectious Diseases consultative service (TxID) pretransplant, and this had a statistically significant association with increased pneumococcal vaccination rates (<i>p</i> = 0.0017, PCV13 and <i>p</i> = 0.0103, PPSV23). In total, 55 patients were included in the lung transplant cohort. Five (9.1%) had baseline hepatitis B immunity; 33/50 (66.0%) completed the hepatitis B vaccine series in the pretransplant setting. Pretransplant PCV13 and PPSV23 vaccination rate was 40.0% (22/55) and 69.1% (38/55), respectively. There was only a 47.3% and 72.3% completion rate overall in the post-transplant setting. (4) Conclusions: There continues to be a need for a comprehensive and coordinated effort to increase vaccine adherence for all SOT candidates in the pretransplant setting.https://www.mdpi.com/2076-393X/8/4/622transplantvaccineheart transplantlung transplantinfectious diseasestransplant infectious diseases |
| spellingShingle | Deeksha Jandhyala Jessica D. Lewis An Analysis of Adherence to Vaccination Recommendations in a Thoracic Organ Transplant Cohort Vaccines transplant vaccine heart transplant lung transplant infectious diseases transplant infectious diseases |
| title | An Analysis of Adherence to Vaccination Recommendations in a Thoracic Organ Transplant Cohort |
| title_full | An Analysis of Adherence to Vaccination Recommendations in a Thoracic Organ Transplant Cohort |
| title_fullStr | An Analysis of Adherence to Vaccination Recommendations in a Thoracic Organ Transplant Cohort |
| title_full_unstemmed | An Analysis of Adherence to Vaccination Recommendations in a Thoracic Organ Transplant Cohort |
| title_short | An Analysis of Adherence to Vaccination Recommendations in a Thoracic Organ Transplant Cohort |
| title_sort | analysis of adherence to vaccination recommendations in a thoracic organ transplant cohort |
| topic | transplant vaccine heart transplant lung transplant infectious diseases transplant infectious diseases |
| url | https://www.mdpi.com/2076-393X/8/4/622 |
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