Association between low selenoprotein P concentrations and anaemia in hospitalized heart failure patients
Abstract Aims Heart failure (HF) patients with anaemia tend to have a worse outcome, with increased hospitalization rates, decreased exercise tolerance, and higher mortality compared to those without anaemia. Limited research exists on the association between selenium deficiency and anaemia specific...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-04-01
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| Series: | ESC Heart Failure |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ehf2.14651 |
| _version_ | 1797242799584706560 |
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| author | Amra Jujić John Molvin Hannes Holm Isholth Anna Dieden Johan Korduner Amir Zaghi Zainu Nezami Andreas Bergmann Lutz Schomburg Martin Magnusson |
| author_facet | Amra Jujić John Molvin Hannes Holm Isholth Anna Dieden Johan Korduner Amir Zaghi Zainu Nezami Andreas Bergmann Lutz Schomburg Martin Magnusson |
| author_sort | Amra Jujić |
| collection | DOAJ |
| description | Abstract Aims Heart failure (HF) patients with anaemia tend to have a worse outcome, with increased hospitalization rates, decreased exercise tolerance, and higher mortality compared to those without anaemia. Limited research exists on the association between selenium deficiency and anaemia specifically in HF patients, despite previous findings of a correlation in different populations. The BIOSTAT‐CHF study demonstrated that higher selenium levels in HF patients were associated to a lower risk of anaemia and iron deficiency. This study investigates the relationship between selenoprotein P (SELENOP) concentrations, a major contributor and functional biomarker of selenium transport, and anaemia, Hb levels, and iron status in hospitalized HF patients. Methods and results SELENOP was analysed in 320 hospitalized HF subjects, with complete data available for 310 subjects. The relationships between continuous SELENOP concentrations and 1) Hb concentrations, 2) anaemia (Hb < 115 g/L (women), <130 g/L (men)), and 3) iron status (as measured by transferrin receptor 1 (TfR1) which increases in iron deficiency) were evaluated using multivariable logistic and linear regression models. Additionally, SELENOP concentrations in the lowest quartile were related to anaemia, haemoglobin, and iron state in multivariable logistic and linear models. The mean age of the study population was 75.0 ± 11.6 years, and 30% were women. Anaemia was present in 133 subjects (42.9%). SELENOP concentrations were positively correlated with haemoglobin concentrations (0.238; P < 0.001) and negatively with TfR1 concentrations (−0.238, P < 0.001). In multivariable regression models, higher SELENOP concentrations were associated with higher Hb concentrations (B = 3.23; P = 0.002) and lower TfR1 concentrations (B = −0.20; P < 0.001). Furthermore, SELENOP deficiency was associated with lower Hb concentrations (B = −7.64: P = 0.001), higher TfR1 concentrations (B = 0.31; P = 0.003), and higher odds of anaemia in HF patients (odds ratio 2.17; 95% confidence interval 1.23–3.82; P = 0.008). Conclusions In hospitalized heart failure patients, lower concentrations of SELENOP were associated with higher prevalence of anaemia. |
| first_indexed | 2024-04-24T18:44:58Z |
| format | Article |
| id | doaj.art-257de28feb2f44a39eb700390d5574e2 |
| institution | Directory Open Access Journal |
| issn | 2055-5822 |
| language | English |
| last_indexed | 2024-04-24T18:44:58Z |
| publishDate | 2024-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | ESC Heart Failure |
| spelling | doaj.art-257de28feb2f44a39eb700390d5574e22024-03-27T06:48:03ZengWileyESC Heart Failure2055-58222024-04-0111287788210.1002/ehf2.14651Association between low selenoprotein P concentrations and anaemia in hospitalized heart failure patientsAmra Jujić0John Molvin1Hannes Holm Isholth2Anna Dieden3Johan Korduner4Amir Zaghi5Zainu Nezami6Andreas Bergmann7Lutz Schomburg8Martin Magnusson9Department of Clinical Sciences Lund University Malmö SwedenDepartment of Clinical Sciences Lund University Malmö SwedenDepartment of Clinical Sciences Lund University Malmö SwedenDepartment of Clinical Sciences Lund University Malmö SwedenDepartment of Clinical Sciences Lund University Malmö SwedenDepartment of Clinical Sciences Lund University Malmö SwedenDepartment of Clinical Sciences Lund University Malmö SwedenSphingotec GmbH Hennigsdorf GermanyCharité ‐ Universitätsmedizin Berlin GermanyDepartment of Clinical Sciences Lund University Malmö SwedenAbstract Aims Heart failure (HF) patients with anaemia tend to have a worse outcome, with increased hospitalization rates, decreased exercise tolerance, and higher mortality compared to those without anaemia. Limited research exists on the association between selenium deficiency and anaemia specifically in HF patients, despite previous findings of a correlation in different populations. The BIOSTAT‐CHF study demonstrated that higher selenium levels in HF patients were associated to a lower risk of anaemia and iron deficiency. This study investigates the relationship between selenoprotein P (SELENOP) concentrations, a major contributor and functional biomarker of selenium transport, and anaemia, Hb levels, and iron status in hospitalized HF patients. Methods and results SELENOP was analysed in 320 hospitalized HF subjects, with complete data available for 310 subjects. The relationships between continuous SELENOP concentrations and 1) Hb concentrations, 2) anaemia (Hb < 115 g/L (women), <130 g/L (men)), and 3) iron status (as measured by transferrin receptor 1 (TfR1) which increases in iron deficiency) were evaluated using multivariable logistic and linear regression models. Additionally, SELENOP concentrations in the lowest quartile were related to anaemia, haemoglobin, and iron state in multivariable logistic and linear models. The mean age of the study population was 75.0 ± 11.6 years, and 30% were women. Anaemia was present in 133 subjects (42.9%). SELENOP concentrations were positively correlated with haemoglobin concentrations (0.238; P < 0.001) and negatively with TfR1 concentrations (−0.238, P < 0.001). In multivariable regression models, higher SELENOP concentrations were associated with higher Hb concentrations (B = 3.23; P = 0.002) and lower TfR1 concentrations (B = −0.20; P < 0.001). Furthermore, SELENOP deficiency was associated with lower Hb concentrations (B = −7.64: P = 0.001), higher TfR1 concentrations (B = 0.31; P = 0.003), and higher odds of anaemia in HF patients (odds ratio 2.17; 95% confidence interval 1.23–3.82; P = 0.008). Conclusions In hospitalized heart failure patients, lower concentrations of SELENOP were associated with higher prevalence of anaemia.https://doi.org/10.1002/ehf2.14651AnaemiaHeart failureHaemoglobinIronSeleniumSelenoprotein P |
| spellingShingle | Amra Jujić John Molvin Hannes Holm Isholth Anna Dieden Johan Korduner Amir Zaghi Zainu Nezami Andreas Bergmann Lutz Schomburg Martin Magnusson Association between low selenoprotein P concentrations and anaemia in hospitalized heart failure patients ESC Heart Failure Anaemia Heart failure Haemoglobin Iron Selenium Selenoprotein P |
| title | Association between low selenoprotein P concentrations and anaemia in hospitalized heart failure patients |
| title_full | Association between low selenoprotein P concentrations and anaemia in hospitalized heart failure patients |
| title_fullStr | Association between low selenoprotein P concentrations and anaemia in hospitalized heart failure patients |
| title_full_unstemmed | Association between low selenoprotein P concentrations and anaemia in hospitalized heart failure patients |
| title_short | Association between low selenoprotein P concentrations and anaemia in hospitalized heart failure patients |
| title_sort | association between low selenoprotein p concentrations and anaemia in hospitalized heart failure patients |
| topic | Anaemia Heart failure Haemoglobin Iron Selenium Selenoprotein P |
| url | https://doi.org/10.1002/ehf2.14651 |
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