Inhibin A as a tumor marker for primary bilateral macronodular adrenal hyperplasia
Primary bilateral macronodular adrenal hyperplasia (PBMAH) is a rare cause of ACTH-independent Cushing syndrome (CS). This condition is characterized by glucocorticoid and/or mineralocorticoid excess, and is commonly regulated by aberrant G-protein coupled receptor expression may be subclinical, all...
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| Format: | Article |
| Language: | English |
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Bioscientifica
2020-05-01
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| Series: | Endocrinology, Diabetes & Metabolism Case Reports |
| Online Access: | https://edm.bioscientifica.com/view/journals/edm/2020/1/EDM20-0006.xml |
| _version_ | 1819266457218842624 |
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| author | Rachel Wurth Crystal Kamilaris Naris Nilubol Samira M Sadowski Annabel Berthon Martha M Quezado Fabio R Faucz Constantine A Stratakis Fady Hannah-Shmouni |
| author_facet | Rachel Wurth Crystal Kamilaris Naris Nilubol Samira M Sadowski Annabel Berthon Martha M Quezado Fabio R Faucz Constantine A Stratakis Fady Hannah-Shmouni |
| author_sort | Rachel Wurth |
| collection | DOAJ |
| description | Primary bilateral macronodular adrenal hyperplasia (PBMAH) is a rare cause of ACTH-independent Cushing syndrome (CS). This condition is characterized by glucocorticoid and/or mineralocorticoid excess, and is commonly regulated by aberrant G-protein coupled receptor expression may be subclinical, allowing the disease to progress for years undetected. Inhibin A is a glycoprotein hormone and tumor marker produced by certain endocrine glands including the adrenal cortex, which has not been previously investigated as a potential tumor marker for PBMAH. In the present report, serum inhibin A levels were evaluated in three patients with PBMAH before and after adrenalectomy. In all cases, serum inhibin A was elevated preoperatively and subsequently fell within the normal range after adrenalectomy. Additionally, adrenal tissues stained positive for inhibin A. We conclude that serum inhibin A levels may be a potential tumor marker for PBMAH. |
| first_indexed | 2024-12-23T21:01:34Z |
| format | Article |
| id | doaj.art-2583f028599342c3a283cd35e7c61b2e |
| institution | Directory Open Access Journal |
| issn | 2052-0573 2052-0573 |
| language | English |
| last_indexed | 2024-12-23T21:01:34Z |
| publishDate | 2020-05-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | Endocrinology, Diabetes & Metabolism Case Reports |
| spelling | doaj.art-2583f028599342c3a283cd35e7c61b2e2022-12-21T17:31:21ZengBioscientificaEndocrinology, Diabetes & Metabolism Case Reports2052-05732052-05732020-05-01111610.1530/EDM-20-0006Inhibin A as a tumor marker for primary bilateral macronodular adrenal hyperplasiaRachel Wurth0Crystal Kamilaris1Naris Nilubol2Samira M Sadowski3Annabel Berthon4Martha M Quezado5Fabio R Faucz6Constantine A Stratakis7Fady Hannah-Shmouni8Section on Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human DevelopmentSection on Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human DevelopmentSurgical Oncology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USASurgical Oncology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USASection on Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human DevelopmentLaboratory of Pathology Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USASection on Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human DevelopmentSection on Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human DevelopmentSection on Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human DevelopmentPrimary bilateral macronodular adrenal hyperplasia (PBMAH) is a rare cause of ACTH-independent Cushing syndrome (CS). This condition is characterized by glucocorticoid and/or mineralocorticoid excess, and is commonly regulated by aberrant G-protein coupled receptor expression may be subclinical, allowing the disease to progress for years undetected. Inhibin A is a glycoprotein hormone and tumor marker produced by certain endocrine glands including the adrenal cortex, which has not been previously investigated as a potential tumor marker for PBMAH. In the present report, serum inhibin A levels were evaluated in three patients with PBMAH before and after adrenalectomy. In all cases, serum inhibin A was elevated preoperatively and subsequently fell within the normal range after adrenalectomy. Additionally, adrenal tissues stained positive for inhibin A. We conclude that serum inhibin A levels may be a potential tumor marker for PBMAH.https://edm.bioscientifica.com/view/journals/edm/2020/1/EDM20-0006.xml |
| spellingShingle | Rachel Wurth Crystal Kamilaris Naris Nilubol Samira M Sadowski Annabel Berthon Martha M Quezado Fabio R Faucz Constantine A Stratakis Fady Hannah-Shmouni Inhibin A as a tumor marker for primary bilateral macronodular adrenal hyperplasia Endocrinology, Diabetes & Metabolism Case Reports |
| title | Inhibin A as a tumor marker for primary bilateral macronodular adrenal hyperplasia |
| title_full | Inhibin A as a tumor marker for primary bilateral macronodular adrenal hyperplasia |
| title_fullStr | Inhibin A as a tumor marker for primary bilateral macronodular adrenal hyperplasia |
| title_full_unstemmed | Inhibin A as a tumor marker for primary bilateral macronodular adrenal hyperplasia |
| title_short | Inhibin A as a tumor marker for primary bilateral macronodular adrenal hyperplasia |
| title_sort | inhibin a as a tumor marker for primary bilateral macronodular adrenal hyperplasia |
| url | https://edm.bioscientifica.com/view/journals/edm/2020/1/EDM20-0006.xml |
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