Transcriptional CDK Inhibitors as Potential Treatment Option for Testicular Germ Cell Tumors

Transcriptional CDK Inhibitors as Potential Treatment Option for Testicular Germ Cell Tumors

Type II testicular germ cell tumors (TGCT) are the most frequently diagnosed solid malignancy in young men. Up to 15% of patients with metastatic non-seminomas show cisplatin resistance and a very poor survival rate due to lacking treatment options. Transcriptional cyclin-dependent kinases (CDK) hav...

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Bibliographic Details
Main Authors: Kai Funke, Robert Düster, Prince De-Graft Wilson, Lena Arévalo, Matthias Geyer, Hubert Schorle
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Cancers
Subjects:
testicular germ cell tumors
transcriptional cyclin-dependent kinase inhibitors
CDK inhibitors
NVP2
SY0351
YKL-5-124
Online Access:https://www.mdpi.com/2072-6694/14/7/1690

Internet

https://www.mdpi.com/2072-6694/14/7/1690

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