Geranylgeranylacetone reduces cardiomyocyte stiffness and attenuates diastolic dysfunction in a rat model of cardiometabolic syndrome

Geranylgeranylacetone reduces cardiomyocyte stiffness and attenuates diastolic dysfunction in a rat model of cardiometabolic syndrome

Abstract Titin‐dependent stiffening of cardiomyocytes is a significant contributor to left ventricular (LV) diastolic dysfunction in heart failure with preserved LV ejection fraction (HFpEF). Small heat shock proteins (HSPs), such as HSPB5 and HSPB1, protect titin and administration of HSPB5 in vitr...

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Bibliographic Details
Main Authors: Mark T. Waddingham, Vasco Sequeira, Diederik W. D. Kuster, Elisa Dal Canto, M. Louis Handoko, Frances S. deMan, Denielli daSilva Gonçalves Bós, Coen A. Ottenheijm, Shengyi Shen, Robbert J. van derPijl, Jolanda van derVelden, Walter J. Paulus, Etto C. Eringa
Format: Article
Language:English
Published: Wiley 2023-11-01
Series:Physiological Reports
Subjects:
cardiomyocyte
diastolic heart failure
ejection fraction
myofilament protein
small heat shock proteins
Online Access:https://doi.org/10.14814/phy2.15788

Internet

https://doi.org/10.14814/phy2.15788

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