Reference Values for Skeletal Muscle Mass at the Third Lumbar Vertebral Level Measured by Computed Tomography in a Healthy Korean Population
Background Sarcopenia is defined as the loss of skeletal muscle mass and is associated with negative clinical outcomes. This study aimed to establish sex-specific cutoff values for the skeletal muscle area (SMA) and skeletal muscle index (SMI) at the third lumbar vertebral (L3) level using computed...
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| Format: | Article |
| Language: | English |
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Korean Endocrine Society
2021-06-01
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| Series: | Endocrinology and Metabolism |
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| Online Access: | http://www.e-enm.org/upload/pdf/enm-2021-1041.pdf |
| _version_ | 1818756361396158464 |
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| author | Ja Kyung Yoon Sunyoung Lee Kyoung Won Kim Ji Eun Lee Jeong Ah Hwang Taeyong Park Jeongjin Lee |
| author_facet | Ja Kyung Yoon Sunyoung Lee Kyoung Won Kim Ji Eun Lee Jeong Ah Hwang Taeyong Park Jeongjin Lee |
| author_sort | Ja Kyung Yoon |
| collection | DOAJ |
| description | Background Sarcopenia is defined as the loss of skeletal muscle mass and is associated with negative clinical outcomes. This study aimed to establish sex-specific cutoff values for the skeletal muscle area (SMA) and skeletal muscle index (SMI) at the third lumbar vertebral (L3) level using computed tomography (CT) imaging to identify sarcopenia in healthy Korean liver donors. Methods This retrospective study included 659 healthy liver donors (408 men and 251 women) aged 20 to 60 years who had undergone abdominal CT examinations between January 2017 and December 2018. Assessment of body composition was performed with an automated segmentation technique using a deep-learning system. Sex-specific SMA and SMI distributions were assessed, and cutoff values for determining sarcopenia were defined as values at either two standard deviations (SDs) below the mean reference value or below the fifth percentile. Results Using the SD definition, cutoff values for SMA and SMI were 117.04 cm2 and 39.33 cm2/m2, respectively, in men and 71.39 cm2 and 27.77 cm2/m2, respectively, in women. Using the fifth percentile definition, cutoff values for SMA and SMI were 126.88 cm2 and 40.96 cm2/m2, respectively, in men and 78.85 cm2 and 30.60 cm2/m2, respectively, in women. Conclusion Our data provide sex-specific cutoff values for the SMA and SMI at the L3 level measured by CT imaging in a healthy Korean population, which may be applicable for identifying sarcopenia in this population. |
| first_indexed | 2024-12-18T05:53:49Z |
| format | Article |
| id | doaj.art-258aeb09086f4b6aa3e9ecf2660ee7e2 |
| institution | Directory Open Access Journal |
| issn | 2093-596X 2093-5978 |
| language | English |
| last_indexed | 2024-12-18T05:53:49Z |
| publishDate | 2021-06-01 |
| publisher | Korean Endocrine Society |
| record_format | Article |
| series | Endocrinology and Metabolism |
| spelling | doaj.art-258aeb09086f4b6aa3e9ecf2660ee7e22022-12-21T21:18:51ZengKorean Endocrine SocietyEndocrinology and Metabolism2093-596X2093-59782021-06-0136367267710.3803/EnM.2021.10412174Reference Values for Skeletal Muscle Mass at the Third Lumbar Vertebral Level Measured by Computed Tomography in a Healthy Korean PopulationJa Kyung Yoon0Sunyoung Lee1Kyoung Won Kim2Ji Eun Lee3Jeong Ah Hwang4Taeyong Park5Jeongjin Lee6 Department of Radiology and Research Institute of Radiological Science, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea Department of Radiology and Research Institute of Radiological Science, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea Department of Radiology, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon, Korea Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea School of Computer Science and Engineering, Soongsil University, Seoul, Korea School of Computer Science and Engineering, Soongsil University, Seoul, KoreaBackground Sarcopenia is defined as the loss of skeletal muscle mass and is associated with negative clinical outcomes. This study aimed to establish sex-specific cutoff values for the skeletal muscle area (SMA) and skeletal muscle index (SMI) at the third lumbar vertebral (L3) level using computed tomography (CT) imaging to identify sarcopenia in healthy Korean liver donors. Methods This retrospective study included 659 healthy liver donors (408 men and 251 women) aged 20 to 60 years who had undergone abdominal CT examinations between January 2017 and December 2018. Assessment of body composition was performed with an automated segmentation technique using a deep-learning system. Sex-specific SMA and SMI distributions were assessed, and cutoff values for determining sarcopenia were defined as values at either two standard deviations (SDs) below the mean reference value or below the fifth percentile. Results Using the SD definition, cutoff values for SMA and SMI were 117.04 cm2 and 39.33 cm2/m2, respectively, in men and 71.39 cm2 and 27.77 cm2/m2, respectively, in women. Using the fifth percentile definition, cutoff values for SMA and SMI were 126.88 cm2 and 40.96 cm2/m2, respectively, in men and 78.85 cm2 and 30.60 cm2/m2, respectively, in women. Conclusion Our data provide sex-specific cutoff values for the SMA and SMI at the L3 level measured by CT imaging in a healthy Korean population, which may be applicable for identifying sarcopenia in this population.http://www.e-enm.org/upload/pdf/enm-2021-1041.pdfreference valuesmuscle, skeletalmultidetector computed tomography, sarcopenia |
| spellingShingle | Ja Kyung Yoon Sunyoung Lee Kyoung Won Kim Ji Eun Lee Jeong Ah Hwang Taeyong Park Jeongjin Lee Reference Values for Skeletal Muscle Mass at the Third Lumbar Vertebral Level Measured by Computed Tomography in a Healthy Korean Population Endocrinology and Metabolism reference values muscle, skeletal multidetector computed tomography, sarcopenia |
| title | Reference Values for Skeletal Muscle Mass at the Third Lumbar Vertebral Level Measured by Computed Tomography in a Healthy Korean Population |
| title_full | Reference Values for Skeletal Muscle Mass at the Third Lumbar Vertebral Level Measured by Computed Tomography in a Healthy Korean Population |
| title_fullStr | Reference Values for Skeletal Muscle Mass at the Third Lumbar Vertebral Level Measured by Computed Tomography in a Healthy Korean Population |
| title_full_unstemmed | Reference Values for Skeletal Muscle Mass at the Third Lumbar Vertebral Level Measured by Computed Tomography in a Healthy Korean Population |
| title_short | Reference Values for Skeletal Muscle Mass at the Third Lumbar Vertebral Level Measured by Computed Tomography in a Healthy Korean Population |
| title_sort | reference values for skeletal muscle mass at the third lumbar vertebral level measured by computed tomography in a healthy korean population |
| topic | reference values muscle, skeletal multidetector computed tomography, sarcopenia |
| url | http://www.e-enm.org/upload/pdf/enm-2021-1041.pdf |
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