Association of timed up and go test outcomes with future incidence of cardiovascular disease and mortality in adults aged 66 years: Korean national representative longitudinal study over 5.7 years
Abstract Background The timed up and go test (TUG) is one of the most widely used tests of mobility. We aimed to examine whether the TUG is associated with cardiovascular (CV) events, CV mortality, and all-cause mortality. Methods Subjects in the senior cohort database of the Korean National Health...
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| Format: | Article |
| Language: | English |
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BMC
2020-03-01
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| Series: | BMC Geriatrics |
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| Online Access: | http://link.springer.com/article/10.1186/s12877-020-01509-8 |
| _version_ | 1818283870992203776 |
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| author | Ki Young Son Dong Wook Shin Ji Eun Lee Sang Hyuck Kim Jae Moon Yun Belong Cho |
| author_facet | Ki Young Son Dong Wook Shin Ji Eun Lee Sang Hyuck Kim Jae Moon Yun Belong Cho |
| author_sort | Ki Young Son |
| collection | DOAJ |
| description | Abstract Background The timed up and go test (TUG) is one of the most widely used tests of mobility. We aimed to examine whether the TUG is associated with cardiovascular (CV) events, CV mortality, and all-cause mortality. Methods Subjects in the senior cohort database of the Korean National Health Insurance Service (2002–2013) who completed the TUG as part of the National Screening Program for Transitional Ages (NSPTA) during 2007–2008 were identified. An abnormal TUG result was defined as a time ≥ 10 s. Cox proportional hazard models were used to assess the associations between TUG results and CV events, CV mortality, and all-cause mortality. Results The mean follow-up period was 5.7 years. Incidence rates of CV events in the normal and abnormal TUG groups were 7.93 and 8.98 per 1000 person-years, while CV mortality rates were 0.96 and 1.51 per 1000 person-years, respectively. In a fully adjusted model, we found that abnormal TUG results were not associated with the incidences of CV events and CV mortality. However, abnormal TUG results (≥10 s) resulted in a 2.9-fold increase in CV mortality in women (adjusted hazard ratio 2.90, 95% confidence interval 1.15–7.30). Further, participants lacking certain CV risk factors, such as current cigarette smoking, obesity, or diabetes, had a higher CV mortality rate when TUG results were abnormal. Conclusions Abnormal TUG results in subjects aged 66 years were associated with future CV mortality in women and in subjects without obesity, diabetes, or cigarette smoking. In patient with mobility impairment, physicians should consider CV disease risk, especially in women. |
| first_indexed | 2024-12-13T00:43:47Z |
| format | Article |
| id | doaj.art-258bdcbb467444da8c534cd5dbb2ef39 |
| institution | Directory Open Access Journal |
| issn | 1471-2318 |
| language | English |
| last_indexed | 2024-12-13T00:43:47Z |
| publishDate | 2020-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Geriatrics |
| spelling | doaj.art-258bdcbb467444da8c534cd5dbb2ef392022-12-22T00:05:05ZengBMCBMC Geriatrics1471-23182020-03-012011910.1186/s12877-020-01509-8Association of timed up and go test outcomes with future incidence of cardiovascular disease and mortality in adults aged 66 years: Korean national representative longitudinal study over 5.7 yearsKi Young Son0Dong Wook Shin1Ji Eun Lee2Sang Hyuck Kim3Jae Moon Yun4Belong Cho5Department of Family Medicine, Asan Medical CenterDepartment of Family Medicine & Supportive Care Center, Samsung Medical Center, Sungkyunkwan University School of MedicineDepartment of Family Medicine, CHA Bungdang Medical Center, CHA UniversityDepartment of Family Medicine, Bumin HospitalHealth Promotion Center, Seoul National University HospitalHealth Promotion Center, Seoul National University HospitalAbstract Background The timed up and go test (TUG) is one of the most widely used tests of mobility. We aimed to examine whether the TUG is associated with cardiovascular (CV) events, CV mortality, and all-cause mortality. Methods Subjects in the senior cohort database of the Korean National Health Insurance Service (2002–2013) who completed the TUG as part of the National Screening Program for Transitional Ages (NSPTA) during 2007–2008 were identified. An abnormal TUG result was defined as a time ≥ 10 s. Cox proportional hazard models were used to assess the associations between TUG results and CV events, CV mortality, and all-cause mortality. Results The mean follow-up period was 5.7 years. Incidence rates of CV events in the normal and abnormal TUG groups were 7.93 and 8.98 per 1000 person-years, while CV mortality rates were 0.96 and 1.51 per 1000 person-years, respectively. In a fully adjusted model, we found that abnormal TUG results were not associated with the incidences of CV events and CV mortality. However, abnormal TUG results (≥10 s) resulted in a 2.9-fold increase in CV mortality in women (adjusted hazard ratio 2.90, 95% confidence interval 1.15–7.30). Further, participants lacking certain CV risk factors, such as current cigarette smoking, obesity, or diabetes, had a higher CV mortality rate when TUG results were abnormal. Conclusions Abnormal TUG results in subjects aged 66 years were associated with future CV mortality in women and in subjects without obesity, diabetes, or cigarette smoking. In patient with mobility impairment, physicians should consider CV disease risk, especially in women.http://link.springer.com/article/10.1186/s12877-020-01509-8Timed up and go testCardiovascular diseaseMortality |
| spellingShingle | Ki Young Son Dong Wook Shin Ji Eun Lee Sang Hyuck Kim Jae Moon Yun Belong Cho Association of timed up and go test outcomes with future incidence of cardiovascular disease and mortality in adults aged 66 years: Korean national representative longitudinal study over 5.7 years BMC Geriatrics Timed up and go test Cardiovascular disease Mortality |
| title | Association of timed up and go test outcomes with future incidence of cardiovascular disease and mortality in adults aged 66 years: Korean national representative longitudinal study over 5.7 years |
| title_full | Association of timed up and go test outcomes with future incidence of cardiovascular disease and mortality in adults aged 66 years: Korean national representative longitudinal study over 5.7 years |
| title_fullStr | Association of timed up and go test outcomes with future incidence of cardiovascular disease and mortality in adults aged 66 years: Korean national representative longitudinal study over 5.7 years |
| title_full_unstemmed | Association of timed up and go test outcomes with future incidence of cardiovascular disease and mortality in adults aged 66 years: Korean national representative longitudinal study over 5.7 years |
| title_short | Association of timed up and go test outcomes with future incidence of cardiovascular disease and mortality in adults aged 66 years: Korean national representative longitudinal study over 5.7 years |
| title_sort | association of timed up and go test outcomes with future incidence of cardiovascular disease and mortality in adults aged 66 years korean national representative longitudinal study over 5 7 years |
| topic | Timed up and go test Cardiovascular disease Mortality |
| url | http://link.springer.com/article/10.1186/s12877-020-01509-8 |
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