Nephroprotective Effect of the Herbal Composition BNO 2103 in Rats with Renal Failure
(1) Background: this research aims at studying the nephroprotective properties of BNO 2103 in a model of chromate-induced renal failure in rats and at proving the possibility of using BNO 2103 in clinical practice for the complex treatment of chronic kidney disease (CKD). (2) Methods: fifty rats div...
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MDPI AG
2020-10-01
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| Series: | Scientia Pharmaceutica |
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| Online Access: | https://www.mdpi.com/2218-0532/88/4/47 |
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| author | Sergii K. Shebeko Vladyslava V. Chernykh Kateryna O. Zupanets |
| author_facet | Sergii K. Shebeko Vladyslava V. Chernykh Kateryna O. Zupanets |
| author_sort | Sergii K. Shebeko |
| collection | DOAJ |
| description | (1) Background: this research aims at studying the nephroprotective properties of BNO 2103 in a model of chromate-induced renal failure in rats and at proving the possibility of using BNO 2103 in clinical practice for the complex treatment of chronic kidney disease (CKD). (2) Methods: fifty rats divided into five groups were studied. The drugs BNO 2103, Prednisolone and Lespephril were administered within 20 days. The excretory function and the functional state of kidneys, blood biochemical parameters and indicators of nitrogen metabolism were determined. (3) Results: under the influence of BNO 2103, there was a significant improvement in renal excretory function, in nitrogen metabolism and blood biochemical parameters compared with the control pathology group. BNO 2103 also outperformed the comparators in most indicators. (4) Conclusions: BNO 2103 has demonstrated nephroprotective, hypoazotemic and diuretic effects; and can be used to implement to the combined therapy of CKD. |
| first_indexed | 2024-03-10T15:38:14Z |
| format | Article |
| id | doaj.art-258dc28863d747d68c983e4c6381e5d7 |
| institution | Directory Open Access Journal |
| issn | 0036-8709 2218-0532 |
| language | English |
| last_indexed | 2024-03-10T15:38:14Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Scientia Pharmaceutica |
| spelling | doaj.art-258dc28863d747d68c983e4c6381e5d72023-11-20T16:59:57ZengMDPI AGScientia Pharmaceutica0036-87092218-05322020-10-018844710.3390/scipharm88040047Nephroprotective Effect of the Herbal Composition BNO 2103 in Rats with Renal FailureSergii K. Shebeko0Vladyslava V. Chernykh1Kateryna O. Zupanets2Department of Clinical Pharmacology and Clinical Pharmacy, National University of Pharmacy, 61002 Kharkiv, UkraineDepartment of Clinical Pharmacology and Clinical Pharmacy, National University of Pharmacy, 61002 Kharkiv, UkraineDepartment of Clinical Pharmacology and Clinical Pharmacy, National University of Pharmacy, 61002 Kharkiv, Ukraine(1) Background: this research aims at studying the nephroprotective properties of BNO 2103 in a model of chromate-induced renal failure in rats and at proving the possibility of using BNO 2103 in clinical practice for the complex treatment of chronic kidney disease (CKD). (2) Methods: fifty rats divided into five groups were studied. The drugs BNO 2103, Prednisolone and Lespephril were administered within 20 days. The excretory function and the functional state of kidneys, blood biochemical parameters and indicators of nitrogen metabolism were determined. (3) Results: under the influence of BNO 2103, there was a significant improvement in renal excretory function, in nitrogen metabolism and blood biochemical parameters compared with the control pathology group. BNO 2103 also outperformed the comparators in most indicators. (4) Conclusions: BNO 2103 has demonstrated nephroprotective, hypoazotemic and diuretic effects; and can be used to implement to the combined therapy of CKD.https://www.mdpi.com/2218-0532/88/4/47chronic kidney diseaseBNO 2103nephroprotective effectphytotherapyexperimental treatment |
| spellingShingle | Sergii K. Shebeko Vladyslava V. Chernykh Kateryna O. Zupanets Nephroprotective Effect of the Herbal Composition BNO 2103 in Rats with Renal Failure Scientia Pharmaceutica chronic kidney disease BNO 2103 nephroprotective effect phytotherapy experimental treatment |
| title | Nephroprotective Effect of the Herbal Composition BNO 2103 in Rats with Renal Failure |
| title_full | Nephroprotective Effect of the Herbal Composition BNO 2103 in Rats with Renal Failure |
| title_fullStr | Nephroprotective Effect of the Herbal Composition BNO 2103 in Rats with Renal Failure |
| title_full_unstemmed | Nephroprotective Effect of the Herbal Composition BNO 2103 in Rats with Renal Failure |
| title_short | Nephroprotective Effect of the Herbal Composition BNO 2103 in Rats with Renal Failure |
| title_sort | nephroprotective effect of the herbal composition bno 2103 in rats with renal failure |
| topic | chronic kidney disease BNO 2103 nephroprotective effect phytotherapy experimental treatment |
| url | https://www.mdpi.com/2218-0532/88/4/47 |
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