Efficacy and side effect of ritodrine and magnesium sulfate in threatened preterm labor
ObjectiveIn terms of efficacy, several previous studies have shown that the success rate in inhibiting preterm labor was not different between magnesium sulfate and ritodrine. However, there is a paucity of information regarding the efficacy of both medications after consideration of intra-amniotic...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Korean Society of Obstetrics and Gynecology
2018-01-01
|
| Series: | Obstetrics & Gynecology Science |
| Subjects: | |
| Online Access: | http://ogscience.org/upload/pdf/ogs-61-63.pdf |
| _version_ | 1819004312424022016 |
|---|---|
| author | Min Kyoung Kim Seung Mi Lee Jung Won Oh So Yeon Kim Hye Gyeong Jeong Sun Min Kim Chan Wook Park Jong Kwan Jun Seo-kyung Hahn Joong Shin Park |
| author_facet | Min Kyoung Kim Seung Mi Lee Jung Won Oh So Yeon Kim Hye Gyeong Jeong Sun Min Kim Chan Wook Park Jong Kwan Jun Seo-kyung Hahn Joong Shin Park |
| author_sort | Min Kyoung Kim |
| collection | DOAJ |
| description | ObjectiveIn terms of efficacy, several previous studies have shown that the success rate in inhibiting preterm labor was not different between magnesium sulfate and ritodrine. However, there is a paucity of information regarding the efficacy of both medications after consideration of intra-amniotic infection, which is one of the most important prognostic factors in patients of threatened preterm birth. The objective of this study was to compare the efficacy and safety of magnesium sulfate with that of ritodrine in preterm labor.MethodsIn this retrospective cohort study, we included patients who were admitted and treated with either ritodrine or magnesium sulfate with the diagnosis of preterm labor at 24–33.6 weeks of gestational age between January 2005 to April 2015. Patients were divided into 2 groups according to the first-used tocolytics (ritodrine group and magnesium sulfate group). We compared the efficacy and prevalence of side effect in each group. The efficacy of both tocolytics was evaluated in terms of preterm delivery within 48 hours, 7 days, or 37 weeks of gestation and need for 2nd line therapy.ResultsA total number of 201 patients were enrolled including 177 cases in ritodrine group and 24 cases in magnesium sulfate group. The efficacy of both tocolytics (preterm delivery within 48 hours, 7 days, or 37 weeks of gestation and need for 2nd line therapy) was not different between the 2 groups of cases. In multivariate analysis, gestational age at treatment, twin gestation, intra-amniotic infection and maternal C-reactive protein (CRP) was associated with treatment failure (preterm delivery within 48 hours), but the type of tocolytics was not significantly associated with treatment failure. The type of side effect was different in the 2 groups, but the frequency of total adverse effect, need for discontinuation of therapy because of maternal adverse effect, and severe adverse effect were not different between the two groups of cases.ConclusionThe efficacy and safety of magnesium sulfate was similar to ritodrine, and can be a substitute tocolytics. Additionally, failure of tocolytic therapy was determined by gestational age at treatment, twin gestation, intra-amniotic infection, and maternal CRP, not by the type of tocolytics. |
| first_indexed | 2024-12-20T23:34:54Z |
| format | Article |
| id | doaj.art-258dce7129974fb899ec44e404615fad |
| institution | Directory Open Access Journal |
| issn | 2287-8572 2287-8580 |
| language | English |
| last_indexed | 2024-12-20T23:34:54Z |
| publishDate | 2018-01-01 |
| publisher | Korean Society of Obstetrics and Gynecology |
| record_format | Article |
| series | Obstetrics & Gynecology Science |
| spelling | doaj.art-258dce7129974fb899ec44e404615fad2022-12-21T19:23:13ZengKorean Society of Obstetrics and GynecologyObstetrics & Gynecology Science2287-85722287-85802018-01-01611637010.5468/ogs.2018.61.1.63536Efficacy and side effect of ritodrine and magnesium sulfate in threatened preterm laborMin Kyoung Kim0Seung Mi Lee1Jung Won Oh2So Yeon Kim3Hye Gyeong Jeong4Sun Min Kim5Chan Wook Park6Jong Kwan Jun7Seo-kyung Hahn8Joong Shin Park9Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, .KoreaDepartment of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, .KoreaDepartment of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, .KoreaDepartment of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, .KoreaDepartment of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, .KoreaSeoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, .KoreaDepartment of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, .KoreaDepartment of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, .KoreaMedical Statistics Lab, Department of Medicine, Seoul National University Hospital, Seoul, .KoreaDepartment of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, .KoreaObjectiveIn terms of efficacy, several previous studies have shown that the success rate in inhibiting preterm labor was not different between magnesium sulfate and ritodrine. However, there is a paucity of information regarding the efficacy of both medications after consideration of intra-amniotic infection, which is one of the most important prognostic factors in patients of threatened preterm birth. The objective of this study was to compare the efficacy and safety of magnesium sulfate with that of ritodrine in preterm labor.MethodsIn this retrospective cohort study, we included patients who were admitted and treated with either ritodrine or magnesium sulfate with the diagnosis of preterm labor at 24–33.6 weeks of gestational age between January 2005 to April 2015. Patients were divided into 2 groups according to the first-used tocolytics (ritodrine group and magnesium sulfate group). We compared the efficacy and prevalence of side effect in each group. The efficacy of both tocolytics was evaluated in terms of preterm delivery within 48 hours, 7 days, or 37 weeks of gestation and need for 2nd line therapy.ResultsA total number of 201 patients were enrolled including 177 cases in ritodrine group and 24 cases in magnesium sulfate group. The efficacy of both tocolytics (preterm delivery within 48 hours, 7 days, or 37 weeks of gestation and need for 2nd line therapy) was not different between the 2 groups of cases. In multivariate analysis, gestational age at treatment, twin gestation, intra-amniotic infection and maternal C-reactive protein (CRP) was associated with treatment failure (preterm delivery within 48 hours), but the type of tocolytics was not significantly associated with treatment failure. The type of side effect was different in the 2 groups, but the frequency of total adverse effect, need for discontinuation of therapy because of maternal adverse effect, and severe adverse effect were not different between the two groups of cases.ConclusionThe efficacy and safety of magnesium sulfate was similar to ritodrine, and can be a substitute tocolytics. Additionally, failure of tocolytic therapy was determined by gestational age at treatment, twin gestation, intra-amniotic infection, and maternal CRP, not by the type of tocolytics.http://ogscience.org/upload/pdf/ogs-61-63.pdfpreterm laborritodrinemagnesium sulfatetocolytics |
| spellingShingle | Min Kyoung Kim Seung Mi Lee Jung Won Oh So Yeon Kim Hye Gyeong Jeong Sun Min Kim Chan Wook Park Jong Kwan Jun Seo-kyung Hahn Joong Shin Park Efficacy and side effect of ritodrine and magnesium sulfate in threatened preterm labor Obstetrics & Gynecology Science preterm labor ritodrine magnesium sulfate tocolytics |
| title | Efficacy and side effect of ritodrine and magnesium sulfate in threatened preterm labor |
| title_full | Efficacy and side effect of ritodrine and magnesium sulfate in threatened preterm labor |
| title_fullStr | Efficacy and side effect of ritodrine and magnesium sulfate in threatened preterm labor |
| title_full_unstemmed | Efficacy and side effect of ritodrine and magnesium sulfate in threatened preterm labor |
| title_short | Efficacy and side effect of ritodrine and magnesium sulfate in threatened preterm labor |
| title_sort | efficacy and side effect of ritodrine and magnesium sulfate in threatened preterm labor |
| topic | preterm labor ritodrine magnesium sulfate tocolytics |
| url | http://ogscience.org/upload/pdf/ogs-61-63.pdf |
| work_keys_str_mv | AT minkyoungkim efficacyandsideeffectofritodrineandmagnesiumsulfateinthreatenedpretermlabor AT seungmilee efficacyandsideeffectofritodrineandmagnesiumsulfateinthreatenedpretermlabor AT jungwonoh efficacyandsideeffectofritodrineandmagnesiumsulfateinthreatenedpretermlabor AT soyeonkim efficacyandsideeffectofritodrineandmagnesiumsulfateinthreatenedpretermlabor AT hyegyeongjeong efficacyandsideeffectofritodrineandmagnesiumsulfateinthreatenedpretermlabor AT sunminkim efficacyandsideeffectofritodrineandmagnesiumsulfateinthreatenedpretermlabor AT chanwookpark efficacyandsideeffectofritodrineandmagnesiumsulfateinthreatenedpretermlabor AT jongkwanjun efficacyandsideeffectofritodrineandmagnesiumsulfateinthreatenedpretermlabor AT seokyunghahn efficacyandsideeffectofritodrineandmagnesiumsulfateinthreatenedpretermlabor AT joongshinpark efficacyandsideeffectofritodrineandmagnesiumsulfateinthreatenedpretermlabor |