Synthesis, characterization and biological activity of Pt(II) complexes with steroidal thiosemicarbazones
In this work, Pt(II) complexes of previously synthesized steroidal thiosemicarbazones were synthesized and characterized. The ligands and their metal complexes were studied by analytical and spectroscopic data (elemental analysis, IR, 1D-NMR and 2D-NMR, HSQC, HMBC, NOESY, COSY), the analysis of whic...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Serbian Chemical Society
2021-01-01
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| Series: | Journal of the Serbian Chemical Society |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0352-5139/2021/0352-51392000083C.pdf |
| _version_ | 1818460894325112832 |
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| author | Čobeljić Božidar R. Živković Marijana B. Matić Ivana Z. Novaković Irena T. Sladić Dušan M. Anđelković Katarina K. Krstić Natalija M. |
| author_facet | Čobeljić Božidar R. Živković Marijana B. Matić Ivana Z. Novaković Irena T. Sladić Dušan M. Anđelković Katarina K. Krstić Natalija M. |
| author_sort | Čobeljić Božidar R. |
| collection | DOAJ |
| description | In this work, Pt(II) complexes of previously synthesized steroidal thiosemicarbazones were synthesized and characterized. The ligands and their metal complexes were studied by analytical and spectroscopic data (elemental analysis, IR, 1D-NMR and 2D-NMR, HSQC, HMBC, NOESY, COSY), the analysis of which enabled complete 1H and 13C assignments of each compound including E and Z isomers. All the synthesized ligands and complexes were screened for their cytotoxic and antimicrobial activity. The results demonstrate that the new steroidal thiosemicarbazone complexes were significantly less cytotoxic than the corresponding steroidal thiosemicarbazones. In addition, complexes showed lower antimicrobial activity than the standard drugs, similar to the activity of the starting thiosemicarbazones. |
| first_indexed | 2024-12-14T23:37:30Z |
| format | Article |
| id | doaj.art-258f5943d69b4abf999a9a276b0d069c |
| institution | Directory Open Access Journal |
| issn | 0352-5139 1820-7421 |
| language | English |
| last_indexed | 2024-12-14T23:37:30Z |
| publishDate | 2021-01-01 |
| publisher | Serbian Chemical Society |
| record_format | Article |
| series | Journal of the Serbian Chemical Society |
| spelling | doaj.art-258f5943d69b4abf999a9a276b0d069c2022-12-21T22:43:35ZengSerbian Chemical SocietyJournal of the Serbian Chemical Society0352-51391820-74212021-01-0186545946810.2298/JSC201211083C0352-51392000083CSynthesis, characterization and biological activity of Pt(II) complexes with steroidal thiosemicarbazonesČobeljić Božidar R.0https://orcid.org/0000-0001-6335-0196Živković Marijana B.1https://orcid.org/0000-0002-1978-1308Matić Ivana Z.2https://orcid.org/0000-0001-7364-2619Novaković Irena T.3https://orcid.org/0000-0001-9881-1204Sladić Dušan M.4https://orcid.org/0000-0002-1000-9813Anđelković Katarina K.5Krstić Natalija M.6https://orcid.org/0000-0002-2356-6803University of Belgrade, Faculty of Chemistry, Belgrade, Republic of SerbiaUniversity of Belgrade, Institute of Chemistry, Technology and Metallurgy, Department of Chemistry, Belgrade, Republic of SerbiaInstitute of Oncology and Radiology of Serbia, Belgrade, Republic of SerbiaUniversity of Belgrade, Institute of Chemistry, Technology and Metallurgy, Department of Chemistry, Belgrade, Republic of SerbiaUniversity of Belgrade, Faculty of Chemistry, Belgrade, Republic of SerbiaUniversity of Belgrade, Faculty of Chemistry, Belgrade, Republic of SerbiaUniversity of Belgrade, Institute of Chemistry, Technology and Metallurgy, Department of Chemistry, Belgrade, Republic of SerbiaIn this work, Pt(II) complexes of previously synthesized steroidal thiosemicarbazones were synthesized and characterized. The ligands and their metal complexes were studied by analytical and spectroscopic data (elemental analysis, IR, 1D-NMR and 2D-NMR, HSQC, HMBC, NOESY, COSY), the analysis of which enabled complete 1H and 13C assignments of each compound including E and Z isomers. All the synthesized ligands and complexes were screened for their cytotoxic and antimicrobial activity. The results demonstrate that the new steroidal thiosemicarbazone complexes were significantly less cytotoxic than the corresponding steroidal thiosemicarbazones. In addition, complexes showed lower antimicrobial activity than the standard drugs, similar to the activity of the starting thiosemicarbazones.http://www.doiserbia.nb.rs/img/doi/0352-5139/2021/0352-51392000083C.pdf3-oxo-αβ-unsaturated steroidshydrazonessquare-planar complexescytotoxicityantimicrobial activity |
| spellingShingle | Čobeljić Božidar R. Živković Marijana B. Matić Ivana Z. Novaković Irena T. Sladić Dušan M. Anđelković Katarina K. Krstić Natalija M. Synthesis, characterization and biological activity of Pt(II) complexes with steroidal thiosemicarbazones Journal of the Serbian Chemical Society 3-oxo-α β-unsaturated steroids hydrazones square-planar complexes cytotoxicity antimicrobial activity |
| title | Synthesis, characterization and biological activity of Pt(II) complexes with steroidal thiosemicarbazones |
| title_full | Synthesis, characterization and biological activity of Pt(II) complexes with steroidal thiosemicarbazones |
| title_fullStr | Synthesis, characterization and biological activity of Pt(II) complexes with steroidal thiosemicarbazones |
| title_full_unstemmed | Synthesis, characterization and biological activity of Pt(II) complexes with steroidal thiosemicarbazones |
| title_short | Synthesis, characterization and biological activity of Pt(II) complexes with steroidal thiosemicarbazones |
| title_sort | synthesis characterization and biological activity of pt ii complexes with steroidal thiosemicarbazones |
| topic | 3-oxo-α β-unsaturated steroids hydrazones square-planar complexes cytotoxicity antimicrobial activity |
| url | http://www.doiserbia.nb.rs/img/doi/0352-5139/2021/0352-51392000083C.pdf |
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