HSP70 Multi-Functionality in Cancer
The 70-kDa heat shock proteins (HSP70s) are abundantly present in cancer, providing malignant cells selective advantage by suppressing multiple apoptotic pathways, regulating necrosis, bypassing cellular senescence program, interfering with tumor immunity, promoting angiogenesis and supporting metas...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-03-01
|
| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/9/3/587 |
| _version_ | 1797761693271457792 |
|---|---|
| author | Zarema Albakova Grigoriy A. Armeev Leonid M. Kanevskiy Elena I. Kovalenko Alexander M. Sapozhnikov |
| author_facet | Zarema Albakova Grigoriy A. Armeev Leonid M. Kanevskiy Elena I. Kovalenko Alexander M. Sapozhnikov |
| author_sort | Zarema Albakova |
| collection | DOAJ |
| description | The 70-kDa heat shock proteins (HSP70s) are abundantly present in cancer, providing malignant cells selective advantage by suppressing multiple apoptotic pathways, regulating necrosis, bypassing cellular senescence program, interfering with tumor immunity, promoting angiogenesis and supporting metastasis. This direct involvement of HSP70 in most of the cancer hallmarks explains the phenomenon of cancer “addiction” to HSP70, tightly linking tumor survival and growth to the HSP70 expression. HSP70 operates in different states through its catalytic cycle, suggesting that it can multi-function in malignant cells in any of these states. Clinically, tumor cells intensively release HSP70 in extracellular microenvironment, resulting in diverse outcomes for patient survival. Given its clinical significance, small molecule inhibitors were developed to target different sites of the HSP70 machinery. Furthermore, several HSP70-based immunotherapy approaches were assessed in clinical trials. This review will explore different roles of HSP70 on cancer progression and emphasize the importance of understanding the flexibility of HSP70 nature for future development of anti-cancer therapies. |
| first_indexed | 2024-03-12T19:17:42Z |
| format | Article |
| id | doaj.art-258fd0f9835248788c76168748c1c73c |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T19:17:42Z |
| publishDate | 2020-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-258fd0f9835248788c76168748c1c73c2023-08-02T05:25:14ZengMDPI AGCells2073-44092020-03-019358710.3390/cells9030587cells9030587HSP70 Multi-Functionality in CancerZarema Albakova0Grigoriy A. Armeev1Leonid M. Kanevskiy2Elena I. Kovalenko3Alexander M. Sapozhnikov4Department of Biology, Lomonosov Moscow State University, 119192 Moscow, RussiaDepartment of Biology, Lomonosov Moscow State University, 119192 Moscow, RussiaDepartment of Immunology, Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 117997 Moscow, RussiaDepartment of Immunology, Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 117997 Moscow, RussiaDepartment of Biology, Lomonosov Moscow State University, 119192 Moscow, RussiaThe 70-kDa heat shock proteins (HSP70s) are abundantly present in cancer, providing malignant cells selective advantage by suppressing multiple apoptotic pathways, regulating necrosis, bypassing cellular senescence program, interfering with tumor immunity, promoting angiogenesis and supporting metastasis. This direct involvement of HSP70 in most of the cancer hallmarks explains the phenomenon of cancer “addiction” to HSP70, tightly linking tumor survival and growth to the HSP70 expression. HSP70 operates in different states through its catalytic cycle, suggesting that it can multi-function in malignant cells in any of these states. Clinically, tumor cells intensively release HSP70 in extracellular microenvironment, resulting in diverse outcomes for patient survival. Given its clinical significance, small molecule inhibitors were developed to target different sites of the HSP70 machinery. Furthermore, several HSP70-based immunotherapy approaches were assessed in clinical trials. This review will explore different roles of HSP70 on cancer progression and emphasize the importance of understanding the flexibility of HSP70 nature for future development of anti-cancer therapies.https://www.mdpi.com/2073-4409/9/3/587hsp70cancerimmunotherapyapoptosisauthophagysenescencemetastasisexosomes |
| spellingShingle | Zarema Albakova Grigoriy A. Armeev Leonid M. Kanevskiy Elena I. Kovalenko Alexander M. Sapozhnikov HSP70 Multi-Functionality in Cancer Cells hsp70 cancer immunotherapy apoptosis authophagy senescence metastasis exosomes |
| title | HSP70 Multi-Functionality in Cancer |
| title_full | HSP70 Multi-Functionality in Cancer |
| title_fullStr | HSP70 Multi-Functionality in Cancer |
| title_full_unstemmed | HSP70 Multi-Functionality in Cancer |
| title_short | HSP70 Multi-Functionality in Cancer |
| title_sort | hsp70 multi functionality in cancer |
| topic | hsp70 cancer immunotherapy apoptosis authophagy senescence metastasis exosomes |
| url | https://www.mdpi.com/2073-4409/9/3/587 |
| work_keys_str_mv | AT zaremaalbakova hsp70multifunctionalityincancer AT grigoriyaarmeev hsp70multifunctionalityincancer AT leonidmkanevskiy hsp70multifunctionalityincancer AT elenaikovalenko hsp70multifunctionalityincancer AT alexandermsapozhnikov hsp70multifunctionalityincancer |