Novel Dental Low-Shrinkage-Stress Composite with Antibacterial Dimethylaminododecyl Methacrylate Monomer
Objectives: Current dental resins exhibit polymerization shrinkage causing microleakage, which has the potential to cause recurrent caries. Our objectives were to create and characterize low-shrinkage-stress (LSS) composites with dimethylaminododecyl methacrylate (DMADDM) as an antibacterial agent t...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Journal of Functional Biomaterials |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-4983/14/7/335 |
| _version_ | 1797588749113098240 |
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| author | Abdullah Alhussein Rashed Alsahafi Xiaohong Wang Heba Mitwalli Hanan Filemban Gary D. Hack Thomas W. Oates Jirun Sun Michael D. Weir Hockin H. K. Xu |
| author_facet | Abdullah Alhussein Rashed Alsahafi Xiaohong Wang Heba Mitwalli Hanan Filemban Gary D. Hack Thomas W. Oates Jirun Sun Michael D. Weir Hockin H. K. Xu |
| author_sort | Abdullah Alhussein |
| collection | DOAJ |
| description | Objectives: Current dental resins exhibit polymerization shrinkage causing microleakage, which has the potential to cause recurrent caries. Our objectives were to create and characterize low-shrinkage-stress (LSS) composites with dimethylaminododecyl methacrylate (DMADDM) as an antibacterial agent to combat recurrent caries. Methods: Triethylene glycol divinylbenzyl ether and urethane dimethacrylate were used to reduce shrinkage stress. DMADDM was incorporated at different mass fractions (0%, 1.5%, 3%, and 5%). Flexural strength, elastic modulus, degree of conversion, polymerization stress, and antimicrobial activity were assessed. Results: The composite with 5% DMADDM demonstrated higher flexural strength than the commercial group (<i>p</i> < 0.05). The addition of DMADDM in BisGMA-TEGDMA resin and LSS resin achieved clinically acceptable degrees of conversion. However, LSS composites exhibited much lower polymerization shrinkage stress than BisGMA-TEGDMA composite groups (<i>p</i> < 0.05). The addition of 3% and 5% DMADDM showed a 6-log reduction in <i>Streptococcus mutans (S. mutans)</i> biofilm CFUs compared to commercial control (<i>p</i> < 0.001). Biofilm biomass and lactic acid were also substantially decreased via DMADDM (<i>p</i> < 0.05). Conclusions: The novel LSS dental composite containing 3% DMADDM demonstrated potent antibacterial action against <i>S. mutans</i> biofilms and much lower polymerization shrinkage-stress, while maintaining excellent mechanical characteristics. The new composite is promising for dental applications to prevent secondary caries and increase restoration longevity. |
| first_indexed | 2024-03-11T00:56:26Z |
| format | Article |
| id | doaj.art-25914b41ca934deebae44199a3fa93d9 |
| institution | Directory Open Access Journal |
| issn | 2079-4983 |
| language | English |
| last_indexed | 2024-03-11T00:56:26Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Functional Biomaterials |
| spelling | doaj.art-25914b41ca934deebae44199a3fa93d92023-11-18T19:56:01ZengMDPI AGJournal of Functional Biomaterials2079-49832023-06-0114733510.3390/jfb14070335Novel Dental Low-Shrinkage-Stress Composite with Antibacterial Dimethylaminododecyl Methacrylate MonomerAbdullah Alhussein0Rashed Alsahafi1Xiaohong Wang2Heba Mitwalli3Hanan Filemban4Gary D. Hack5Thomas W. Oates6Jirun Sun7Michael D. Weir8Hockin H. K. Xu9PhD Program in Dental Biomedical Sciences, University of Maryland School of Dentistry, Baltimore, MD 21201, USADepartment of Restorative Dental Sciences, Umm Al-Qura University, College of Dentistry, Makkah 24211, Saudi ArabiaAmerican Dental Association Science and Research Institute, LLC., Gaithersburg, MD 20899, USADepartment of Restorative Dental Sciences, College of Dentistry, King Saud University, Riyadh 11451, Saudi ArabiaDepartment of Operative Dentistry, Faculty of Dentistry, King Abdulaziz University, Jeddah 21589, Saudi ArabiaBiomaterials & Tissue Engineering Division, Department of Advanced Oral Sciences and Therapeutics, University Maryland School of Dentistry, Baltimore, MD 21201, USABiomaterials & Tissue Engineering Division, Department of Advanced Oral Sciences and Therapeutics, University Maryland School of Dentistry, Baltimore, MD 21201, USAThe Forsyth Institute, Harvard School of Dental Medicine Affiliate, Cambridge, MA 02142, USABiomaterials & Tissue Engineering Division, Department of Advanced Oral Sciences and Therapeutics, University Maryland School of Dentistry, Baltimore, MD 21201, USABiomaterials & Tissue Engineering Division, Department of Advanced Oral Sciences and Therapeutics, University Maryland School of Dentistry, Baltimore, MD 21201, USAObjectives: Current dental resins exhibit polymerization shrinkage causing microleakage, which has the potential to cause recurrent caries. Our objectives were to create and characterize low-shrinkage-stress (LSS) composites with dimethylaminododecyl methacrylate (DMADDM) as an antibacterial agent to combat recurrent caries. Methods: Triethylene glycol divinylbenzyl ether and urethane dimethacrylate were used to reduce shrinkage stress. DMADDM was incorporated at different mass fractions (0%, 1.5%, 3%, and 5%). Flexural strength, elastic modulus, degree of conversion, polymerization stress, and antimicrobial activity were assessed. Results: The composite with 5% DMADDM demonstrated higher flexural strength than the commercial group (<i>p</i> < 0.05). The addition of DMADDM in BisGMA-TEGDMA resin and LSS resin achieved clinically acceptable degrees of conversion. However, LSS composites exhibited much lower polymerization shrinkage stress than BisGMA-TEGDMA composite groups (<i>p</i> < 0.05). The addition of 3% and 5% DMADDM showed a 6-log reduction in <i>Streptococcus mutans (S. mutans)</i> biofilm CFUs compared to commercial control (<i>p</i> < 0.001). Biofilm biomass and lactic acid were also substantially decreased via DMADDM (<i>p</i> < 0.05). Conclusions: The novel LSS dental composite containing 3% DMADDM demonstrated potent antibacterial action against <i>S. mutans</i> biofilms and much lower polymerization shrinkage-stress, while maintaining excellent mechanical characteristics. The new composite is promising for dental applications to prevent secondary caries and increase restoration longevity.https://www.mdpi.com/2079-4983/14/7/335oral biofilmscariesantibacterialbio-interactiveresin compositelow polymerization stress |
| spellingShingle | Abdullah Alhussein Rashed Alsahafi Xiaohong Wang Heba Mitwalli Hanan Filemban Gary D. Hack Thomas W. Oates Jirun Sun Michael D. Weir Hockin H. K. Xu Novel Dental Low-Shrinkage-Stress Composite with Antibacterial Dimethylaminododecyl Methacrylate Monomer Journal of Functional Biomaterials oral biofilms caries antibacterial bio-interactive resin composite low polymerization stress |
| title | Novel Dental Low-Shrinkage-Stress Composite with Antibacterial Dimethylaminododecyl Methacrylate Monomer |
| title_full | Novel Dental Low-Shrinkage-Stress Composite with Antibacterial Dimethylaminododecyl Methacrylate Monomer |
| title_fullStr | Novel Dental Low-Shrinkage-Stress Composite with Antibacterial Dimethylaminododecyl Methacrylate Monomer |
| title_full_unstemmed | Novel Dental Low-Shrinkage-Stress Composite with Antibacterial Dimethylaminododecyl Methacrylate Monomer |
| title_short | Novel Dental Low-Shrinkage-Stress Composite with Antibacterial Dimethylaminododecyl Methacrylate Monomer |
| title_sort | novel dental low shrinkage stress composite with antibacterial dimethylaminododecyl methacrylate monomer |
| topic | oral biofilms caries antibacterial bio-interactive resin composite low polymerization stress |
| url | https://www.mdpi.com/2079-4983/14/7/335 |
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