Comparison of Phytochemicals, Antioxidant, and In Vitro Anti-Alzheimer Properties of Twenty-Seven <i>Morus</i> spp. Cultivated in Thailand
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder. To fight the disease, natural products, including mulberry, with antioxidant activities and inhibitory activities against key enzymes (acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and beta-secretase 1 (BACE-1)) are o...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-06-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/25/11/2600 |
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| author | Piya Temviriyanukul Varittha Sritalahareuthai Kriskamol Na Jom Butsara Jongruaysup Somying Tabtimsri Kanchana Pruesapan Sirinapa Thangsiri Woorawee Inthachat Dalad Siriwan Somsri Charoenkiatkul Uthaiwan Suttisansanee |
| author_facet | Piya Temviriyanukul Varittha Sritalahareuthai Kriskamol Na Jom Butsara Jongruaysup Somying Tabtimsri Kanchana Pruesapan Sirinapa Thangsiri Woorawee Inthachat Dalad Siriwan Somsri Charoenkiatkul Uthaiwan Suttisansanee |
| author_sort | Piya Temviriyanukul |
| collection | DOAJ |
| description | Alzheimer’s disease (AD) is a progressive neurodegenerative disorder. To fight the disease, natural products, including mulberry, with antioxidant activities and inhibitory activities against key enzymes (acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and beta-secretase 1 (BACE-1)) are of interest. However, even in the same cultivars, mulberry trees grown in different populated locations might possess disparate amounts of phytochemical profiles, leading to dissimilar health properties, which cause problems when comparing different cultivars of mulberry. Therefore, this study aimed to comparatively investigate the phytochemicals, antioxidant activities, and inhibitory activities against AChE, BChE, and BACE-1, of twenty-seven <i>Morus</i> spp. cultivated in the same planting area in Thailand. The results suggested that <i>Morus</i> fruit samples were rich in phenolics, especially cyanidin, kuromanin, and keracyanin. Besides, the aqueous <i>Morus</i> fruit extracts exhibited antioxidant activities, both in single electron transfer (SET) and hydrogen atom transfer (HAT) mechanisms, while strong inhibitory activities against AD key enzymes were observed. Interestingly, among the twenty-seven <i>Morus</i> spp., <i>Morus</i> sp. code SKSM 810191 with high phytochemicals, antioxidant activities and in vitro anti-AD properties is a promising cultivar for further developed as a potential mulberry resource with health benefits against AD. |
| first_indexed | 2024-03-10T19:23:32Z |
| format | Article |
| id | doaj.art-2591b5e7205649a6a3d88f320de75680 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T19:23:32Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-2591b5e7205649a6a3d88f320de756802023-11-20T02:44:48ZengMDPI AGMolecules1420-30492020-06-012511260010.3390/molecules25112600Comparison of Phytochemicals, Antioxidant, and In Vitro Anti-Alzheimer Properties of Twenty-Seven <i>Morus</i> spp. Cultivated in ThailandPiya Temviriyanukul0Varittha Sritalahareuthai1Kriskamol Na Jom2Butsara Jongruaysup3Somying Tabtimsri4Kanchana Pruesapan5Sirinapa Thangsiri6Woorawee Inthachat7Dalad Siriwan8Somsri Charoenkiatkul9Uthaiwan Suttisansanee10Institute of Nutrition, Mahidol University, Salaya, Phuttamonthon, Nakhon Pathom 73170, ThailandInstitute of Nutrition, Mahidol University, Salaya, Phuttamonthon, Nakhon Pathom 73170, ThailandDepartment of Food Science and Technology, Faculty of Agro-Industry, Kasetsart University, Chatuchak, Bangkok 10900, ThailandOffice of Sericulture Conservation and Standard Conformity Assessment, The Queen Sirikit Department of Sericulture, Ministry of Agriculture and Cooperatives, Bangkok 10900, ThailandThe Queen Sirikit Department of Sericulture Center (Kanchanaburi), Nong Ya, Mueang Kanchanaburi District, Kanchanaburi 71000, ThailandPlant Varieties Protection Office, Department of Agriculture, Ministry of Agriculture and Cooperatives, Bangkok 10900, ThailandInstitute of Nutrition, Mahidol University, Salaya, Phuttamonthon, Nakhon Pathom 73170, ThailandInstitute of Nutrition, Mahidol University, Salaya, Phuttamonthon, Nakhon Pathom 73170, ThailandInstitute of Food Research and Product Development, Kasetsart University, Chatuchak, Bangkok 10900, ThailandInstitute of Nutrition, Mahidol University, Salaya, Phuttamonthon, Nakhon Pathom 73170, ThailandInstitute of Nutrition, Mahidol University, Salaya, Phuttamonthon, Nakhon Pathom 73170, ThailandAlzheimer’s disease (AD) is a progressive neurodegenerative disorder. To fight the disease, natural products, including mulberry, with antioxidant activities and inhibitory activities against key enzymes (acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and beta-secretase 1 (BACE-1)) are of interest. However, even in the same cultivars, mulberry trees grown in different populated locations might possess disparate amounts of phytochemical profiles, leading to dissimilar health properties, which cause problems when comparing different cultivars of mulberry. Therefore, this study aimed to comparatively investigate the phytochemicals, antioxidant activities, and inhibitory activities against AChE, BChE, and BACE-1, of twenty-seven <i>Morus</i> spp. cultivated in the same planting area in Thailand. The results suggested that <i>Morus</i> fruit samples were rich in phenolics, especially cyanidin, kuromanin, and keracyanin. Besides, the aqueous <i>Morus</i> fruit extracts exhibited antioxidant activities, both in single electron transfer (SET) and hydrogen atom transfer (HAT) mechanisms, while strong inhibitory activities against AD key enzymes were observed. Interestingly, among the twenty-seven <i>Morus</i> spp., <i>Morus</i> sp. code SKSM 810191 with high phytochemicals, antioxidant activities and in vitro anti-AD properties is a promising cultivar for further developed as a potential mulberry resource with health benefits against AD.https://www.mdpi.com/1420-3049/25/11/2600<i>Morus</i> speciesanthocyaninsanthocyanidinsbeta-secretase 1antioxidantanti-Alzheimer properties |
| spellingShingle | Piya Temviriyanukul Varittha Sritalahareuthai Kriskamol Na Jom Butsara Jongruaysup Somying Tabtimsri Kanchana Pruesapan Sirinapa Thangsiri Woorawee Inthachat Dalad Siriwan Somsri Charoenkiatkul Uthaiwan Suttisansanee Comparison of Phytochemicals, Antioxidant, and In Vitro Anti-Alzheimer Properties of Twenty-Seven <i>Morus</i> spp. Cultivated in Thailand Molecules <i>Morus</i> species anthocyanins anthocyanidins beta-secretase 1 antioxidant anti-Alzheimer properties |
| title | Comparison of Phytochemicals, Antioxidant, and In Vitro Anti-Alzheimer Properties of Twenty-Seven <i>Morus</i> spp. Cultivated in Thailand |
| title_full | Comparison of Phytochemicals, Antioxidant, and In Vitro Anti-Alzheimer Properties of Twenty-Seven <i>Morus</i> spp. Cultivated in Thailand |
| title_fullStr | Comparison of Phytochemicals, Antioxidant, and In Vitro Anti-Alzheimer Properties of Twenty-Seven <i>Morus</i> spp. Cultivated in Thailand |
| title_full_unstemmed | Comparison of Phytochemicals, Antioxidant, and In Vitro Anti-Alzheimer Properties of Twenty-Seven <i>Morus</i> spp. Cultivated in Thailand |
| title_short | Comparison of Phytochemicals, Antioxidant, and In Vitro Anti-Alzheimer Properties of Twenty-Seven <i>Morus</i> spp. Cultivated in Thailand |
| title_sort | comparison of phytochemicals antioxidant and in vitro anti alzheimer properties of twenty seven i morus i spp cultivated in thailand |
| topic | <i>Morus</i> species anthocyanins anthocyanidins beta-secretase 1 antioxidant anti-Alzheimer properties |
| url | https://www.mdpi.com/1420-3049/25/11/2600 |
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