The Role of Platelet-Rich Plasma in Reducing Pain, Pruritis, and Improving Wound Healing of Skin Graft Donor Site
Background Wound healing is a dynamic and complex process. Therefore, no single agent can efficiently mediate all aspects of the wound healing process. Split-thickness graft has become a workhorse of plastic surgery for wound or raw area cover. In this study, we evaluate the effectiveness of autolog...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Thieme Medical Publishers, Inc.
2022-12-01
|
| Series: | Indian Journal of Plastic Surgery |
| Subjects: | |
| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0042-1759502 |
| _version_ | 1797945174434775040 |
|---|---|
| author | Sheikh Sarfraz Ali Imran Ahmad Mohammed Fahud Khurram Gautam Chaudhury Somnath Karad Sudanshu Tripathi Aditi Sharma |
| author_facet | Sheikh Sarfraz Ali Imran Ahmad Mohammed Fahud Khurram Gautam Chaudhury Somnath Karad Sudanshu Tripathi Aditi Sharma |
| author_sort | Sheikh Sarfraz Ali |
| collection | DOAJ |
| description | Background Wound healing is a dynamic and complex process. Therefore, no single agent can efficiently mediate all aspects of the wound healing process. Split-thickness graft has become a workhorse of plastic surgery for wound or raw area cover. In this study, we evaluate the effectiveness of autologous platelet-rich plasma (PRP) on the donor site and its effect in pain, purities, and epithelization.
Materials and Methods This is a prospective study. A total of 15 patients were included who underwent split skin grafting for burns, trauma, or post-tumor excision raw area. PRP was prepared using standard described procedure. The donor site raw area after harvesting split-thickness graft was measured and the surface area was divided into two equal halves. One half was dressed using PRP and the other half was dressed using paraffin gauze piece only. The dressings were changed weekly for 3 weeks.
Observation We found significant reduction in severity of pain and pruritis in the PRP group as compared with control group. Epithelization was faster in the PRP group on day 7 and 14, but the overall healing time was nearly the same by day 21. The side-by-side dressing thus show a definite improvement in the post-split-thickness skin graft wound care and PRP as a good dressing alternative.
Conclusion Autologous PRP is very effective adjuvant in management of skin graft donor site. Its role in relieving pain and pruritis over donor site significantly improves patient's discomfort postoperatively. It helps in early and painless wound healing. However, we recommend for larger clinical study for better understanding of the efficacy of this blood product. |
| first_indexed | 2024-04-10T20:50:59Z |
| format | Article |
| id | doaj.art-2592928c6c574ed4beb52b0380e522bc |
| institution | Directory Open Access Journal |
| issn | 0970-0358 1998-376X |
| language | English |
| last_indexed | 2024-04-10T20:50:59Z |
| publishDate | 2022-12-01 |
| publisher | Thieme Medical Publishers, Inc. |
| record_format | Article |
| series | Indian Journal of Plastic Surgery |
| spelling | doaj.art-2592928c6c574ed4beb52b0380e522bc2023-01-23T09:42:03ZengThieme Medical Publishers, Inc.Indian Journal of Plastic Surgery0970-03581998-376X2022-12-01550437638210.1055/s-0042-1759502The Role of Platelet-Rich Plasma in Reducing Pain, Pruritis, and Improving Wound Healing of Skin Graft Donor SiteSheikh Sarfraz Ali0Imran Ahmad1Mohammed Fahud Khurram2Gautam Chaudhury3Somnath Karad4Sudanshu Tripathi5Aditi Sharma6Department of Plastic Surgery, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, IndiaDepartment of Plastic Surgery, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, IndiaDepartment of Plastic Surgery, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, IndiaDepartment of Plastic Surgery, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, IndiaDepartment of Plastic Surgery, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, IndiaDepartment of Plastic Surgery, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, IndiaDepartment of Plastic Surgery, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, IndiaBackground Wound healing is a dynamic and complex process. Therefore, no single agent can efficiently mediate all aspects of the wound healing process. Split-thickness graft has become a workhorse of plastic surgery for wound or raw area cover. In this study, we evaluate the effectiveness of autologous platelet-rich plasma (PRP) on the donor site and its effect in pain, purities, and epithelization. Materials and Methods This is a prospective study. A total of 15 patients were included who underwent split skin grafting for burns, trauma, or post-tumor excision raw area. PRP was prepared using standard described procedure. The donor site raw area after harvesting split-thickness graft was measured and the surface area was divided into two equal halves. One half was dressed using PRP and the other half was dressed using paraffin gauze piece only. The dressings were changed weekly for 3 weeks. Observation We found significant reduction in severity of pain and pruritis in the PRP group as compared with control group. Epithelization was faster in the PRP group on day 7 and 14, but the overall healing time was nearly the same by day 21. The side-by-side dressing thus show a definite improvement in the post-split-thickness skin graft wound care and PRP as a good dressing alternative. Conclusion Autologous PRP is very effective adjuvant in management of skin graft donor site. Its role in relieving pain and pruritis over donor site significantly improves patient's discomfort postoperatively. It helps in early and painless wound healing. However, we recommend for larger clinical study for better understanding of the efficacy of this blood product.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0042-1759502prpsplit-thickness skin graftskin graft donor site |
| spellingShingle | Sheikh Sarfraz Ali Imran Ahmad Mohammed Fahud Khurram Gautam Chaudhury Somnath Karad Sudanshu Tripathi Aditi Sharma The Role of Platelet-Rich Plasma in Reducing Pain, Pruritis, and Improving Wound Healing of Skin Graft Donor Site Indian Journal of Plastic Surgery prp split-thickness skin graft skin graft donor site |
| title | The Role of Platelet-Rich Plasma in Reducing Pain, Pruritis, and Improving Wound Healing of Skin Graft Donor Site |
| title_full | The Role of Platelet-Rich Plasma in Reducing Pain, Pruritis, and Improving Wound Healing of Skin Graft Donor Site |
| title_fullStr | The Role of Platelet-Rich Plasma in Reducing Pain, Pruritis, and Improving Wound Healing of Skin Graft Donor Site |
| title_full_unstemmed | The Role of Platelet-Rich Plasma in Reducing Pain, Pruritis, and Improving Wound Healing of Skin Graft Donor Site |
| title_short | The Role of Platelet-Rich Plasma in Reducing Pain, Pruritis, and Improving Wound Healing of Skin Graft Donor Site |
| title_sort | role of platelet rich plasma in reducing pain pruritis and improving wound healing of skin graft donor site |
| topic | prp split-thickness skin graft skin graft donor site |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0042-1759502 |
| work_keys_str_mv | AT sheikhsarfrazali theroleofplateletrichplasmainreducingpainpruritisandimprovingwoundhealingofskingraftdonorsite AT imranahmad theroleofplateletrichplasmainreducingpainpruritisandimprovingwoundhealingofskingraftdonorsite AT mohammedfahudkhurram theroleofplateletrichplasmainreducingpainpruritisandimprovingwoundhealingofskingraftdonorsite AT gautamchaudhury theroleofplateletrichplasmainreducingpainpruritisandimprovingwoundhealingofskingraftdonorsite AT somnathkarad theroleofplateletrichplasmainreducingpainpruritisandimprovingwoundhealingofskingraftdonorsite AT sudanshutripathi theroleofplateletrichplasmainreducingpainpruritisandimprovingwoundhealingofskingraftdonorsite AT aditisharma theroleofplateletrichplasmainreducingpainpruritisandimprovingwoundhealingofskingraftdonorsite AT sheikhsarfrazali roleofplateletrichplasmainreducingpainpruritisandimprovingwoundhealingofskingraftdonorsite AT imranahmad roleofplateletrichplasmainreducingpainpruritisandimprovingwoundhealingofskingraftdonorsite AT mohammedfahudkhurram roleofplateletrichplasmainreducingpainpruritisandimprovingwoundhealingofskingraftdonorsite AT gautamchaudhury roleofplateletrichplasmainreducingpainpruritisandimprovingwoundhealingofskingraftdonorsite AT somnathkarad roleofplateletrichplasmainreducingpainpruritisandimprovingwoundhealingofskingraftdonorsite AT sudanshutripathi roleofplateletrichplasmainreducingpainpruritisandimprovingwoundhealingofskingraftdonorsite AT aditisharma roleofplateletrichplasmainreducingpainpruritisandimprovingwoundhealingofskingraftdonorsite |