Thieno[2,3-d]pyrimidine based derivatives as kinase inhibitors and anticancer agents
Thienopyrimidines are fused heterocyclic ring systems; structurally resemble purines, exerting pharmacological potential in different aspects. They are known to play a crucial role in various disease conditions. Thieno[2,3-d]pyrimidine derivatives have been explored for their inhibitory activities t...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2015-12-01
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| Series: | Future Journal of Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S231472451530011X |
| _version_ | 1819179508556627968 |
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| author | Eman Z. Elrazaz Rabah A.T. Serya Nasser S.M. Ismail Dalal A. Abou El Ella Khaled A.M. Abouzid |
| author_facet | Eman Z. Elrazaz Rabah A.T. Serya Nasser S.M. Ismail Dalal A. Abou El Ella Khaled A.M. Abouzid |
| author_sort | Eman Z. Elrazaz |
| collection | DOAJ |
| description | Thienopyrimidines are fused heterocyclic ring systems; structurally resemble purines, exerting pharmacological potential in different aspects. They are known to play a crucial role in various disease conditions. Thieno[2,3-d]pyrimidine derivatives have been explored for their inhibitory activities towards various protein kinase enzymes. The present review is a compilation on chemical synthesis and biological anticancer significance, via inhibition of specific protein kinase enzymes, including structure–activity relationships of thieno[2,3-d]pyrimidines derivatives reported to date. |
| first_indexed | 2024-12-22T21:59:34Z |
| format | Article |
| id | doaj.art-2594703950904b439d171b25769cc25c |
| institution | Directory Open Access Journal |
| issn | 2314-7245 |
| language | English |
| last_indexed | 2024-12-22T21:59:34Z |
| publishDate | 2015-12-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Future Journal of Pharmaceutical Sciences |
| spelling | doaj.art-2594703950904b439d171b25769cc25c2022-12-21T18:11:09ZengSpringerOpenFuture Journal of Pharmaceutical Sciences2314-72452015-12-0112334110.1016/j.fjps.2015.09.001Thieno[2,3-d]pyrimidine based derivatives as kinase inhibitors and anticancer agentsEman Z. ElrazazRabah A.T. SeryaNasser S.M. IsmailDalal A. Abou El EllaKhaled A.M. AbouzidThienopyrimidines are fused heterocyclic ring systems; structurally resemble purines, exerting pharmacological potential in different aspects. They are known to play a crucial role in various disease conditions. Thieno[2,3-d]pyrimidine derivatives have been explored for their inhibitory activities towards various protein kinase enzymes. The present review is a compilation on chemical synthesis and biological anticancer significance, via inhibition of specific protein kinase enzymes, including structure–activity relationships of thieno[2,3-d]pyrimidines derivatives reported to date.http://www.sciencedirect.com/science/article/pii/S231472451530011XKinase inhibitorsThieno[2,3-d]pyrimidineSynthetic strategySAR |
| spellingShingle | Eman Z. Elrazaz Rabah A.T. Serya Nasser S.M. Ismail Dalal A. Abou El Ella Khaled A.M. Abouzid Thieno[2,3-d]pyrimidine based derivatives as kinase inhibitors and anticancer agents Future Journal of Pharmaceutical Sciences Kinase inhibitors Thieno[2,3-d]pyrimidine Synthetic strategy SAR |
| title | Thieno[2,3-d]pyrimidine based derivatives as kinase inhibitors and anticancer agents |
| title_full | Thieno[2,3-d]pyrimidine based derivatives as kinase inhibitors and anticancer agents |
| title_fullStr | Thieno[2,3-d]pyrimidine based derivatives as kinase inhibitors and anticancer agents |
| title_full_unstemmed | Thieno[2,3-d]pyrimidine based derivatives as kinase inhibitors and anticancer agents |
| title_short | Thieno[2,3-d]pyrimidine based derivatives as kinase inhibitors and anticancer agents |
| title_sort | thieno 2 3 d pyrimidine based derivatives as kinase inhibitors and anticancer agents |
| topic | Kinase inhibitors Thieno[2,3-d]pyrimidine Synthetic strategy SAR |
| url | http://www.sciencedirect.com/science/article/pii/S231472451530011X |
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