Design of Novel 4-Aminobenzofuroxans and Evaluation of Their Antimicrobial and Anticancer Activity

Design of Novel 4-Aminobenzofuroxans and Evaluation of Their Antimicrobial and Anticancer Activity

A series of novel 4-aminobenzofuroxan derivatives containing aromatic/aliphatic amines fragments was achieved via aromatic nucleophilic substitution reaction of 4,6-dichloro-5-nitrobenzofuroxan. The quantum chemistry calculations were performed to identify the factors affecting the regioselectivity...

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Bibliographic Details
Main Authors: Elena Chugunova, Almir Gazizov, Marina Sazykina, Nurgali Akylbekov, Anastasiya Gildebrant, Ivan Sazykin, Alexander Burilov, Nurbol Appazov, Shorena Karchava, Maria Klimova, Alexandra Voloshina, Anastasia Sapunova, Syumbelya Gumerova, Ayrat Khamatgalimov, Tatiana Gerasimova, Alexey Dobrynin, Olga Gogoleva, Vladimir Gorshkov
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:International Journal of Molecular Sciences
Subjects:
benzofuroxan
anti-cancer activity
apoptosis
bacterial biofilm
fungistatic activity
quantum chemical calculations
Online Access:https://www.mdpi.com/1422-0067/21/21/8292

Internet

https://www.mdpi.com/1422-0067/21/21/8292

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