Bipolar Disorder and Diabetes Mellitus
Comorbid endocrine and cardiovascular situations with bipolar disorder usually result from the bipolar disorder itself or as a consequence of its treatment. With habits and lifestyle, genetic tendency and side effects, this situation is becoming more striking. Subpopulations of bipolar disorders pat...
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| Format: | Article |
| Language: | English |
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Psikiyatride Güncel Yaklaşımlar
2010-04-01
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| Series: | Psikiyatride Güncel Yaklaşımlar |
| Subjects: | |
| Online Access: | http://www.cappsy.org/archives/vol2/no1/cap_02_05.pdf |
| _version_ | 1797328896952107008 |
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| author | Sermin Kesebir A. Gorkem Gençer |
| author_facet | Sermin Kesebir A. Gorkem Gençer |
| author_sort | Sermin Kesebir |
| collection | DOAJ |
| description | Comorbid endocrine and cardiovascular situations with bipolar disorder usually result from the bipolar disorder itself or as a consequence of its treatment. With habits and lifestyle, genetic tendency and side effects, this situation is becoming more striking. Subpopulations of bipolar disorders patients should be considered at high risk for diabetes mellitus. The prevalence of diabetes mellitus in bipolar disorder may be three times greater than in the general population. Comorbidity of diabetes causes a pathophysiological overlapping in the neurobiological webs of bipolar cases. Signal mechanisms of glycocorticoid/insulin and immunoinflammatory effector systems are junction points that point out the pathophysiology between bipolar disorder and general medical cases susceptible to stress. Glycogen synthetase kinase (GSK-3) is a serine/treonine kinase and inhibits the transport of glucose stimulated by insulin. It is affected in diabetes, cancer, inflammation, Alzheimer disease and bipolar disorder. Hypoglycemic effect of lithium occurs via inhibiting glycogen synthetase kinase. When comorbid with diabetes, the other disease -for example bipolar disorder, especially during its acute manic episodes-, causes a serious situation that presents its influences for a lifetime. Choosing pharmacological treatment and treatment adherence are another important interrelated areas. The aim of this article is to discuss and review the etiological, clinical and therapeutic properties of diabetes mellitus and bipolar disorder comorbidity. |
| first_indexed | 2024-03-08T06:58:35Z |
| format | Article |
| id | doaj.art-25960472e5b141b9bab27239f4781799 |
| institution | Directory Open Access Journal |
| issn | 1309-0658 1309-0674 |
| language | English |
| last_indexed | 2024-03-08T06:58:35Z |
| publishDate | 2010-04-01 |
| publisher | Psikiyatride Güncel Yaklaşımlar |
| record_format | Article |
| series | Psikiyatride Güncel Yaklaşımlar |
| spelling | doaj.art-25960472e5b141b9bab27239f47817992024-02-03T06:22:54ZengPsikiyatride Güncel YaklaşımlarPsikiyatride Güncel Yaklaşımlar1309-06581309-06742010-04-01216674Bipolar Disorder and Diabetes MellitusSermin KesebirA. Gorkem GençerComorbid endocrine and cardiovascular situations with bipolar disorder usually result from the bipolar disorder itself or as a consequence of its treatment. With habits and lifestyle, genetic tendency and side effects, this situation is becoming more striking. Subpopulations of bipolar disorders patients should be considered at high risk for diabetes mellitus. The prevalence of diabetes mellitus in bipolar disorder may be three times greater than in the general population. Comorbidity of diabetes causes a pathophysiological overlapping in the neurobiological webs of bipolar cases. Signal mechanisms of glycocorticoid/insulin and immunoinflammatory effector systems are junction points that point out the pathophysiology between bipolar disorder and general medical cases susceptible to stress. Glycogen synthetase kinase (GSK-3) is a serine/treonine kinase and inhibits the transport of glucose stimulated by insulin. It is affected in diabetes, cancer, inflammation, Alzheimer disease and bipolar disorder. Hypoglycemic effect of lithium occurs via inhibiting glycogen synthetase kinase. When comorbid with diabetes, the other disease -for example bipolar disorder, especially during its acute manic episodes-, causes a serious situation that presents its influences for a lifetime. Choosing pharmacological treatment and treatment adherence are another important interrelated areas. The aim of this article is to discuss and review the etiological, clinical and therapeutic properties of diabetes mellitus and bipolar disorder comorbidity.http://www.cappsy.org/archives/vol2/no1/cap_02_05.pdfBipolar DisorderDiabetes MellitusLate OnsetComorbidity |
| spellingShingle | Sermin Kesebir A. Gorkem Gençer Bipolar Disorder and Diabetes Mellitus Psikiyatride Güncel Yaklaşımlar Bipolar Disorder Diabetes Mellitus Late Onset Comorbidity |
| title | Bipolar Disorder and Diabetes Mellitus |
| title_full | Bipolar Disorder and Diabetes Mellitus |
| title_fullStr | Bipolar Disorder and Diabetes Mellitus |
| title_full_unstemmed | Bipolar Disorder and Diabetes Mellitus |
| title_short | Bipolar Disorder and Diabetes Mellitus |
| title_sort | bipolar disorder and diabetes mellitus |
| topic | Bipolar Disorder Diabetes Mellitus Late Onset Comorbidity |
| url | http://www.cappsy.org/archives/vol2/no1/cap_02_05.pdf |
| work_keys_str_mv | AT serminkesebir bipolardisorderanddiabetesmellitus AT agorkemgencer bipolardisorderanddiabetesmellitus |