Long‐term risk of cardiovascular mortality in lymphoma survivors: A systematic review and meta‐analysis
Abstract Cardiovascular disease has been identified as one of the late complications of cancer therapy. The purpose of this study was to quantify the long‐term risk of cardiovascular mortality among lymphoma survivors relative to that of the general population. A systematic review and meta‐analysis...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-09-01
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| Series: | Cancer Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cam4.1572 |
| _version_ | 1811289532589408256 |
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| author | Devon J. Boyne Alexis T. Mickle Darren R. Brenner Christine M. Friedenreich Winson Y. Cheung Karen L. Tang Todd A. Wilson Diane L. Lorenzetti Matthew T. James Paul E. Ronksley Doreen M. Rabi |
| author_facet | Devon J. Boyne Alexis T. Mickle Darren R. Brenner Christine M. Friedenreich Winson Y. Cheung Karen L. Tang Todd A. Wilson Diane L. Lorenzetti Matthew T. James Paul E. Ronksley Doreen M. Rabi |
| author_sort | Devon J. Boyne |
| collection | DOAJ |
| description | Abstract Cardiovascular disease has been identified as one of the late complications of cancer therapy. The purpose of this study was to quantify the long‐term risk of cardiovascular mortality among lymphoma survivors relative to that of the general population. A systematic review and meta‐analysis were conducted. Articles were identified in November 2016 by searching EMBASE, MEDLINE, and CINAHL databases. Observational studies were included if they assessed cardiovascular mortality in patients with lymphoma who survived for at least 5 years from time of diagnosis or if they had a median follow‐up of 10 years. A pooled standardized mortality ratio (SMR) was estimated using a DerSimonian and Laird random‐effects model. The Q and I2 statistics were used to assess heterogeneity. Funnel plots and Begg's and Egger's tests were used to evaluate publication bias. Of the 7450 articles screened, 27 studies were included in the systematic review representing 46 829 Hodgkin and 14 764 non‐Hodgkin lymphoma survivors. The pooled number of deaths attributable to cardiovascular disease among Hodgkin and non‐Hodgkin disease was estimated to be 7.31 (95% CI: 5.29‐10.10; I2 = 95.4%) and 5.35 (95% CI: 2.55‐11.24; I2 = 94.0%) times that of the general population, respectively. This association was greater among Hodgkin lymphoma survivors treated before the age of 21 (pooled SMR = 13.43; 95% CI: 9.22‐19.57; I2 = 78.9%). There was a high degree of heterogeneity and a high risk of bias due to confounding in this body of literature. Lymphoma survivors have an increased risk of fatal cardiovascular events compared to the general population and should be targeted for cardiovascular screening and prevention campaigns. |
| first_indexed | 2024-04-13T03:56:22Z |
| format | Article |
| id | doaj.art-259655a7be634846829057db0fb1572d |
| institution | Directory Open Access Journal |
| issn | 2045-7634 |
| language | English |
| last_indexed | 2024-04-13T03:56:22Z |
| publishDate | 2018-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj.art-259655a7be634846829057db0fb1572d2022-12-22T03:03:37ZengWileyCancer Medicine2045-76342018-09-01794801481310.1002/cam4.1572Long‐term risk of cardiovascular mortality in lymphoma survivors: A systematic review and meta‐analysisDevon J. Boyne0Alexis T. Mickle1Darren R. Brenner2Christine M. Friedenreich3Winson Y. Cheung4Karen L. Tang5Todd A. Wilson6Diane L. Lorenzetti7Matthew T. James8Paul E. Ronksley9Doreen M. Rabi10Department of Cancer Epidemiology and Prevention Research Cancer Control Alberta Alberta Health Services Calgary AB CanadaDepartment of Cancer Epidemiology and Prevention Research Cancer Control Alberta Alberta Health Services Calgary AB CanadaDepartment of Cancer Epidemiology and Prevention Research Cancer Control Alberta Alberta Health Services Calgary AB CanadaDepartment of Cancer Epidemiology and Prevention Research Cancer Control Alberta Alberta Health Services Calgary AB CanadaDepartment of Community Health Sciences Cumming School of Medicine University of Calgary Calgary AB CanadaDepartment of Medicine Cumming School of Medicine University of Calgary Calgary AB CanadaDepartment of Community Health Sciences Cumming School of Medicine University of Calgary Calgary AB CanadaDepartment of Community Health Sciences Cumming School of Medicine University of Calgary Calgary AB CanadaDepartment of Community Health Sciences Cumming School of Medicine University of Calgary Calgary AB CanadaDepartment of Community Health Sciences Cumming School of Medicine University of Calgary Calgary AB CanadaDepartment of Community Health Sciences Cumming School of Medicine University of Calgary Calgary AB CanadaAbstract Cardiovascular disease has been identified as one of the late complications of cancer therapy. The purpose of this study was to quantify the long‐term risk of cardiovascular mortality among lymphoma survivors relative to that of the general population. A systematic review and meta‐analysis were conducted. Articles were identified in November 2016 by searching EMBASE, MEDLINE, and CINAHL databases. Observational studies were included if they assessed cardiovascular mortality in patients with lymphoma who survived for at least 5 years from time of diagnosis or if they had a median follow‐up of 10 years. A pooled standardized mortality ratio (SMR) was estimated using a DerSimonian and Laird random‐effects model. The Q and I2 statistics were used to assess heterogeneity. Funnel plots and Begg's and Egger's tests were used to evaluate publication bias. Of the 7450 articles screened, 27 studies were included in the systematic review representing 46 829 Hodgkin and 14 764 non‐Hodgkin lymphoma survivors. The pooled number of deaths attributable to cardiovascular disease among Hodgkin and non‐Hodgkin disease was estimated to be 7.31 (95% CI: 5.29‐10.10; I2 = 95.4%) and 5.35 (95% CI: 2.55‐11.24; I2 = 94.0%) times that of the general population, respectively. This association was greater among Hodgkin lymphoma survivors treated before the age of 21 (pooled SMR = 13.43; 95% CI: 9.22‐19.57; I2 = 78.9%). There was a high degree of heterogeneity and a high risk of bias due to confounding in this body of literature. Lymphoma survivors have an increased risk of fatal cardiovascular events compared to the general population and should be targeted for cardiovascular screening and prevention campaigns.https://doi.org/10.1002/cam4.1572cardiovascular diseaseHodgkinlymphomameta‐analysismortalitystandardized mortality ratio |
| spellingShingle | Devon J. Boyne Alexis T. Mickle Darren R. Brenner Christine M. Friedenreich Winson Y. Cheung Karen L. Tang Todd A. Wilson Diane L. Lorenzetti Matthew T. James Paul E. Ronksley Doreen M. Rabi Long‐term risk of cardiovascular mortality in lymphoma survivors: A systematic review and meta‐analysis Cancer Medicine cardiovascular disease Hodgkin lymphoma meta‐analysis mortality standardized mortality ratio |
| title | Long‐term risk of cardiovascular mortality in lymphoma survivors: A systematic review and meta‐analysis |
| title_full | Long‐term risk of cardiovascular mortality in lymphoma survivors: A systematic review and meta‐analysis |
| title_fullStr | Long‐term risk of cardiovascular mortality in lymphoma survivors: A systematic review and meta‐analysis |
| title_full_unstemmed | Long‐term risk of cardiovascular mortality in lymphoma survivors: A systematic review and meta‐analysis |
| title_short | Long‐term risk of cardiovascular mortality in lymphoma survivors: A systematic review and meta‐analysis |
| title_sort | long term risk of cardiovascular mortality in lymphoma survivors a systematic review and meta analysis |
| topic | cardiovascular disease Hodgkin lymphoma meta‐analysis mortality standardized mortality ratio |
| url | https://doi.org/10.1002/cam4.1572 |
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