Heat Shock Protein 90 as Therapeutic Target for CVDs and Heart Ageing
Cardiovascular diseases (CVDs) are the leading cause of death globally, representing approximately 32% of all deaths worldwide. Molecular chaperones are involved in heart protection against stresses and age-mediated accumulation of toxic misfolded proteins by regulation of the protein synthesis/degr...
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| Format: | Article |
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MDPI AG
2022-01-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/2/649 |
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| author | Siarhei A. Dabravolski Vasily N. Sukhorukov Vladislav A. Kalmykov Nikolay A. Orekhov Andrey V. Grechko Alexander N. Orekhov |
| author_facet | Siarhei A. Dabravolski Vasily N. Sukhorukov Vladislav A. Kalmykov Nikolay A. Orekhov Andrey V. Grechko Alexander N. Orekhov |
| author_sort | Siarhei A. Dabravolski |
| collection | DOAJ |
| description | Cardiovascular diseases (CVDs) are the leading cause of death globally, representing approximately 32% of all deaths worldwide. Molecular chaperones are involved in heart protection against stresses and age-mediated accumulation of toxic misfolded proteins by regulation of the protein synthesis/degradation balance and refolding of misfolded proteins, thus supporting the high metabolic demand of the heart cells. Heat shock protein 90 (HSP90) is one of the main cardioprotective chaperones, represented by cytosolic <i>HSP90a</i> and <i>HSP90b</i>, mitochondrial <i>TRAP1</i> and ER-localised <i>Grp94</i> isoforms. Currently, the main way to study the functional role of HSPs is the application of HSP inhibitors, which could have a different way of action. In this review, we discussed the recently investigated role of HSP90 proteins in cardioprotection, atherosclerosis, CVDs development and the involvements of HSP90 clients in the activation of different molecular pathways and signalling mechanisms, related to heart ageing. |
| first_indexed | 2024-03-10T01:19:45Z |
| format | Article |
| id | doaj.art-2597da3bc8724d1ab269350d3146be00 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T01:19:45Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-2597da3bc8724d1ab269350d3146be002023-11-23T14:01:56ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-01-0123264910.3390/ijms23020649Heat Shock Protein 90 as Therapeutic Target for CVDs and Heart AgeingSiarhei A. Dabravolski0Vasily N. Sukhorukov1Vladislav A. Kalmykov2Nikolay A. Orekhov3Andrey V. Grechko4Alexander N. Orekhov5Department of Clinical Diagnostics, Vitebsk State Academy of Veterinary Medicine [UO VGAVM], 7/11 Dovatora Str., 210026 Vitebsk, BelarusLaboratory of Cellular and Molecular Pathology of Cardiovascular System, AP Avtsyn Research Institute of Human Morphology, 3 Tsyurupy Str., 117418 Moscow, RussiaLaboratory of Cellular and Molecular Pathology of Cardiovascular System, AP Avtsyn Research Institute of Human Morphology, 3 Tsyurupy Str., 117418 Moscow, RussiaInstitute for Atherosclerosis Research, 4-1-207 Osennyaya Str., 121609 Moscow, RussiaFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, 14-3 Solyanka Str., 109240 Moscow, RussiaInstitute for Atherosclerosis Research, 4-1-207 Osennyaya Str., 121609 Moscow, RussiaCardiovascular diseases (CVDs) are the leading cause of death globally, representing approximately 32% of all deaths worldwide. Molecular chaperones are involved in heart protection against stresses and age-mediated accumulation of toxic misfolded proteins by regulation of the protein synthesis/degradation balance and refolding of misfolded proteins, thus supporting the high metabolic demand of the heart cells. Heat shock protein 90 (HSP90) is one of the main cardioprotective chaperones, represented by cytosolic <i>HSP90a</i> and <i>HSP90b</i>, mitochondrial <i>TRAP1</i> and ER-localised <i>Grp94</i> isoforms. Currently, the main way to study the functional role of HSPs is the application of HSP inhibitors, which could have a different way of action. In this review, we discussed the recently investigated role of HSP90 proteins in cardioprotection, atherosclerosis, CVDs development and the involvements of HSP90 clients in the activation of different molecular pathways and signalling mechanisms, related to heart ageing.https://www.mdpi.com/1422-0067/23/2/649heat shock proteinchaperonecardiovascular diseasesatherosclerosisageing |
| spellingShingle | Siarhei A. Dabravolski Vasily N. Sukhorukov Vladislav A. Kalmykov Nikolay A. Orekhov Andrey V. Grechko Alexander N. Orekhov Heat Shock Protein 90 as Therapeutic Target for CVDs and Heart Ageing International Journal of Molecular Sciences heat shock protein chaperone cardiovascular diseases atherosclerosis ageing |
| title | Heat Shock Protein 90 as Therapeutic Target for CVDs and Heart Ageing |
| title_full | Heat Shock Protein 90 as Therapeutic Target for CVDs and Heart Ageing |
| title_fullStr | Heat Shock Protein 90 as Therapeutic Target for CVDs and Heart Ageing |
| title_full_unstemmed | Heat Shock Protein 90 as Therapeutic Target for CVDs and Heart Ageing |
| title_short | Heat Shock Protein 90 as Therapeutic Target for CVDs and Heart Ageing |
| title_sort | heat shock protein 90 as therapeutic target for cvds and heart ageing |
| topic | heat shock protein chaperone cardiovascular diseases atherosclerosis ageing |
| url | https://www.mdpi.com/1422-0067/23/2/649 |
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