Malignant Transformation Rate in Chinese Patients with Oral Leukoplakia: a Meta-analysis
Background Oral cancer is highly prevalent, which is often caused by oral potentially malignant disorders, and oral leukoplakia is the most common. The malignant transformation of oral leukoplakia not only affects the physical and mental health of patients, but also imposesa heavy economic burden on...
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| Format: | Article |
| Language: | zho |
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Chinese General Practice Publishing House Co., Ltd
2023-02-01
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| Series: | Zhongguo quanke yixue |
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| Online Access: | https://www.chinagp.net/fileup/1007-9572/PDF/zx20220303.pdf |
| _version_ | 1797216817563828224 |
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| author | YANG Ling, HOU Lili, CHEN Weihong, WENG Ximei, LUO Shasha, XIA Jialin |
| author_facet | YANG Ling, HOU Lili, CHEN Weihong, WENG Ximei, LUO Shasha, XIA Jialin |
| author_sort | YANG Ling, HOU Lili, CHEN Weihong, WENG Ximei, LUO Shasha, XIA Jialin |
| collection | DOAJ |
| description | Background Oral cancer is highly prevalent, which is often caused by oral potentially malignant disorders, and oral leukoplakia is the most common. The malignant transformation of oral leukoplakia not only affects the physical and mental health of patients, but also imposesa heavy economic burden on the patient's families and society. Due to limited sample size, regional differences and other factors, the epidemiological characteristics of malignant transformation in Chinese patients with oral leukoplakia in China are various. Objective To perform a systematic review of the malignant transformation rate of oral leukoplakia in Chinese patients. Methods Databases of CNKI, SinoMed, CQVIP, Wanfang Data, PubMed, Web of Science, Embase and Cochrane Library were searched to identify cohort studies about malignant transformation rate of oral leukoplakia in Chinese patients included from inception to February 2022. Two researchers separately screened the cohort studies, evaluated the qualities and extracted data. Meta-analysis was conducted using Stata 15.0. Results Thirty cohort studies including 109 047 patients were finally included. Meta-analysis revealed that the malignant transformation rate of oral leukoplakia in Chinese patients was 9.0%〔95%CI (7.0%, 11.3%) 〕. The results of subgroup analysis revealed that the malignant transformation rate was 7.6% in male patients〔95%CI (5.1%, 10.6%) 〕, and was 13.2% in female patients〔95%CI (9.5%, 17.4%) 〕. The malignant transformation rate of oral leukoplakia in patients aged <60 years was 12.3%〔95%CI (9.2%, 15.7%) 〕, and was 17.9% in those aged ≥60 years 〔95%CI (13.8%, 22.5%) 〕. The malignant transformation rate of tongue leukoplakia was 16.2%〔95%CI (11.0%, 22.2%) 〕, and that of leukoplakia of other parts of the oral cavity was 6.1%〔95%CI (3.2%, 9.6%) 〕. Conclusion Current evidence shows that the malignant transformation rate of oral leukoplakia in Chinese patients is relatively high, female, age ≥ 60 years, tongue oral leukoplakia malignant rate is higher. |
| first_indexed | 2024-04-24T11:51:59Z |
| format | Article |
| id | doaj.art-259c2eb96f0a46eca56a6a0f81e9d7da |
| institution | Directory Open Access Journal |
| issn | 1007-9572 |
| language | zho |
| last_indexed | 2024-04-24T11:51:59Z |
| publishDate | 2023-02-01 |
| publisher | Chinese General Practice Publishing House Co., Ltd |
| record_format | Article |
| series | Zhongguo quanke yixue |
| spelling | doaj.art-259c2eb96f0a46eca56a6a0f81e9d7da2024-04-09T07:05:55ZzhoChinese General Practice Publishing House Co., LtdZhongguo quanke yixue1007-95722023-02-01260562162810.12114/j.issn.1007-9572.2022.0303Malignant Transformation Rate in Chinese Patients with Oral Leukoplakia: a Meta-analysisYANG Ling, HOU Lili, CHEN Weihong, WENG Ximei, LUO Shasha, XIA Jialin01. School of Nursing, Chengdu University of TCM, Chengdu 610075, China;2. Nursing Department, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, China;3. Nursing Department, Hospital of Chengdu University of TCM, Chengdu 610072, ChinaBackground Oral cancer is highly prevalent, which is often caused by oral potentially malignant disorders, and oral leukoplakia is the most common. The malignant transformation of oral leukoplakia not only affects the physical and mental health of patients, but also imposesa heavy economic burden on the patient's families and society. Due to limited sample size, regional differences and other factors, the epidemiological characteristics of malignant transformation in Chinese patients with oral leukoplakia in China are various. Objective To perform a systematic review of the malignant transformation rate of oral leukoplakia in Chinese patients. Methods Databases of CNKI, SinoMed, CQVIP, Wanfang Data, PubMed, Web of Science, Embase and Cochrane Library were searched to identify cohort studies about malignant transformation rate of oral leukoplakia in Chinese patients included from inception to February 2022. Two researchers separately screened the cohort studies, evaluated the qualities and extracted data. Meta-analysis was conducted using Stata 15.0. Results Thirty cohort studies including 109 047 patients were finally included. Meta-analysis revealed that the malignant transformation rate of oral leukoplakia in Chinese patients was 9.0%〔95%CI (7.0%, 11.3%) 〕. The results of subgroup analysis revealed that the malignant transformation rate was 7.6% in male patients〔95%CI (5.1%, 10.6%) 〕, and was 13.2% in female patients〔95%CI (9.5%, 17.4%) 〕. The malignant transformation rate of oral leukoplakia in patients aged <60 years was 12.3%〔95%CI (9.2%, 15.7%) 〕, and was 17.9% in those aged ≥60 years 〔95%CI (13.8%, 22.5%) 〕. The malignant transformation rate of tongue leukoplakia was 16.2%〔95%CI (11.0%, 22.2%) 〕, and that of leukoplakia of other parts of the oral cavity was 6.1%〔95%CI (3.2%, 9.6%) 〕. Conclusion Current evidence shows that the malignant transformation rate of oral leukoplakia in Chinese patients is relatively high, female, age ≥ 60 years, tongue oral leukoplakia malignant rate is higher.https://www.chinagp.net/fileup/1007-9572/PDF/zx20220303.pdforal leukoplakia|malignant transformation rate|meta-analysis|cohort study|china |
| spellingShingle | YANG Ling, HOU Lili, CHEN Weihong, WENG Ximei, LUO Shasha, XIA Jialin Malignant Transformation Rate in Chinese Patients with Oral Leukoplakia: a Meta-analysis Zhongguo quanke yixue oral leukoplakia|malignant transformation rate|meta-analysis|cohort study|china |
| title | Malignant Transformation Rate in Chinese Patients with Oral Leukoplakia: a Meta-analysis |
| title_full | Malignant Transformation Rate in Chinese Patients with Oral Leukoplakia: a Meta-analysis |
| title_fullStr | Malignant Transformation Rate in Chinese Patients with Oral Leukoplakia: a Meta-analysis |
| title_full_unstemmed | Malignant Transformation Rate in Chinese Patients with Oral Leukoplakia: a Meta-analysis |
| title_short | Malignant Transformation Rate in Chinese Patients with Oral Leukoplakia: a Meta-analysis |
| title_sort | malignant transformation rate in chinese patients with oral leukoplakia a meta analysis |
| topic | oral leukoplakia|malignant transformation rate|meta-analysis|cohort study|china |
| url | https://www.chinagp.net/fileup/1007-9572/PDF/zx20220303.pdf |
| work_keys_str_mv | AT yanglinghoulilichenweihongwengximeiluoshashaxiajialin malignanttransformationrateinchinesepatientswithoralleukoplakiaametaanalysis |