Autoantibody against transient receptor potential M1 cation channels of retinal ON bipolar cells in paraneoplastic vitelliform retinopathy
<p>Abstract</p> <p>Background</p> <p>Paraneoplastic retinopathy is caused by the cross-reaction of neoplasm-directed autoantibodies against retinal antigens and results in retinal damage. Paraneoplastic vitelliform retinopathy, a presumed paraneoplastic retinopathy with...
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| Format: | Article |
| Language: | English |
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BMC
2012-11-01
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| Series: | BMC Ophthalmology |
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| Online Access: | http://www.biomedcentral.com/1471-2415/12/56 |
| _version_ | 1818541086497308672 |
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| author | Wang Yujuan Abu-Asab Mones S Li Wei Aronow Mary E Singh Arun D Chan Chi-Chao |
| author_facet | Wang Yujuan Abu-Asab Mones S Li Wei Aronow Mary E Singh Arun D Chan Chi-Chao |
| author_sort | Wang Yujuan |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Paraneoplastic retinopathy is caused by the cross-reaction of neoplasm-directed autoantibodies against retinal antigens and results in retinal damage. Paraneoplastic vitelliform retinopathy, a presumed paraneoplastic retinopathy with features of atypical melanoma-associated retinopathy, has recently been reported in patients with metastatic melanoma. Ocular ultrastructure and its autoantibody localization of paraneoplastic vitelliform retinopathy are still indefinable. This is the first report of anti-transient receptor potential M1 antibody directly against human retinal bipolar dendritic tips in a melanoma patient with paraneoplastic vitelliform retinopathy.</p> <p>Case presentation</p> <p>We present a pair of postmortem eyes of an 80-year-old male with metastatic cutaneous melanoma, who developed paraneoplastic vitelliform retinopathy. The autopsied eyes were examined with light microscopy, immunohistochemistry, and transmission electron microscopy. Microscopically, the inner nuclear layer and outer plexiform layer were the most affected retinal structures, with local thinning. The lesions extended to the outer nuclear layer, resulting in focal retinal degeneration, edema, and atrophy. No active inflammation or melanoma cells were observed. Immunohistochemistry showed tightly compact bipolar cell nuclei (protein kinase C alpha/calbindin positive) with blur/loss of ON bipolar cell dendritic tips (transient receptor potential M1 positive) in diffusely condensed outer plexiform layer. The metastatic melanoma cells in his lung also showed immunoreactivity against transient receptor potential M1 antibody. Transmission electron microscopy illustrated degenerated inner nuclear layer with disintegration of cells and loss of cytoplasmic organelles. These cells contained many lysosomal and autophagous bodies and damaged mitochondria. Their nuclei appeared pyknotic and fragmentary. The synapses in the outer plexiform layer were extensively degenerated and replaced with empty vacuoles and disintegrated organelles.</p> <p>Conclusion</p> <p>This case provides a convincing histological evidence of melanoma-associated autoantibodies directly against transient receptor potential M1 channels that target the ON bipolar cell structures in the inner nuclear and outer plexiform layers in paraneoplastic vitelliform retinopathy.</p> |
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| language | English |
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| spelling | doaj.art-259d0fb6aa69494aa05399c2d2154bac2022-12-22T00:49:01ZengBMCBMC Ophthalmology1471-24152012-11-011215610.1186/1471-2415-12-56Autoantibody against transient receptor potential M1 cation channels of retinal ON bipolar cells in paraneoplastic vitelliform retinopathyWang YujuanAbu-Asab Mones SLi WeiAronow Mary ESingh Arun DChan Chi-Chao<p>Abstract</p> <p>Background</p> <p>Paraneoplastic retinopathy is caused by the cross-reaction of neoplasm-directed autoantibodies against retinal antigens and results in retinal damage. Paraneoplastic vitelliform retinopathy, a presumed paraneoplastic retinopathy with features of atypical melanoma-associated retinopathy, has recently been reported in patients with metastatic melanoma. Ocular ultrastructure and its autoantibody localization of paraneoplastic vitelliform retinopathy are still indefinable. This is the first report of anti-transient receptor potential M1 antibody directly against human retinal bipolar dendritic tips in a melanoma patient with paraneoplastic vitelliform retinopathy.</p> <p>Case presentation</p> <p>We present a pair of postmortem eyes of an 80-year-old male with metastatic cutaneous melanoma, who developed paraneoplastic vitelliform retinopathy. The autopsied eyes were examined with light microscopy, immunohistochemistry, and transmission electron microscopy. Microscopically, the inner nuclear layer and outer plexiform layer were the most affected retinal structures, with local thinning. The lesions extended to the outer nuclear layer, resulting in focal retinal degeneration, edema, and atrophy. No active inflammation or melanoma cells were observed. Immunohistochemistry showed tightly compact bipolar cell nuclei (protein kinase C alpha/calbindin positive) with blur/loss of ON bipolar cell dendritic tips (transient receptor potential M1 positive) in diffusely condensed outer plexiform layer. The metastatic melanoma cells in his lung also showed immunoreactivity against transient receptor potential M1 antibody. Transmission electron microscopy illustrated degenerated inner nuclear layer with disintegration of cells and loss of cytoplasmic organelles. These cells contained many lysosomal and autophagous bodies and damaged mitochondria. Their nuclei appeared pyknotic and fragmentary. The synapses in the outer plexiform layer were extensively degenerated and replaced with empty vacuoles and disintegrated organelles.</p> <p>Conclusion</p> <p>This case provides a convincing histological evidence of melanoma-associated autoantibodies directly against transient receptor potential M1 channels that target the ON bipolar cell structures in the inner nuclear and outer plexiform layers in paraneoplastic vitelliform retinopathy.</p>http://www.biomedcentral.com/1471-2415/12/56Paraneoplastic vitelliform retinopathyAutoimmune retinopathyTransient receptor potential channelBipolar cellMelanoma-associated retinopathyAutoantibody |
| spellingShingle | Wang Yujuan Abu-Asab Mones S Li Wei Aronow Mary E Singh Arun D Chan Chi-Chao Autoantibody against transient receptor potential M1 cation channels of retinal ON bipolar cells in paraneoplastic vitelliform retinopathy BMC Ophthalmology Paraneoplastic vitelliform retinopathy Autoimmune retinopathy Transient receptor potential channel Bipolar cell Melanoma-associated retinopathy Autoantibody |
| title | Autoantibody against transient receptor potential M1 cation channels of retinal ON bipolar cells in paraneoplastic vitelliform retinopathy |
| title_full | Autoantibody against transient receptor potential M1 cation channels of retinal ON bipolar cells in paraneoplastic vitelliform retinopathy |
| title_fullStr | Autoantibody against transient receptor potential M1 cation channels of retinal ON bipolar cells in paraneoplastic vitelliform retinopathy |
| title_full_unstemmed | Autoantibody against transient receptor potential M1 cation channels of retinal ON bipolar cells in paraneoplastic vitelliform retinopathy |
| title_short | Autoantibody against transient receptor potential M1 cation channels of retinal ON bipolar cells in paraneoplastic vitelliform retinopathy |
| title_sort | autoantibody against transient receptor potential m1 cation channels of retinal on bipolar cells in paraneoplastic vitelliform retinopathy |
| topic | Paraneoplastic vitelliform retinopathy Autoimmune retinopathy Transient receptor potential channel Bipolar cell Melanoma-associated retinopathy Autoantibody |
| url | http://www.biomedcentral.com/1471-2415/12/56 |
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