Targeting the PD-1/PD-L1 Axis in Human Vitiligo

Autoreactive CD8+ T cells play a pivotal role in melanocyte destruction in autoimmune vitiligo. Immunotherapy for melanoma often leads to autoimmune side-effects, among which vitiligo-like depigmentation, indicating that targeting immune checkpoints can break peripheral tolerance against self-antige...

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Main Authors: Marcella Willemsen, Cornelis J. M. Melief, Marcel W. Bekkenk, Rosalie M. Luiten
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Immunology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.579022/full
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author Marcella Willemsen
Cornelis J. M. Melief
Marcel W. Bekkenk
Rosalie M. Luiten
author_facet Marcella Willemsen
Cornelis J. M. Melief
Marcel W. Bekkenk
Rosalie M. Luiten
author_sort Marcella Willemsen
collection DOAJ
description Autoreactive CD8+ T cells play a pivotal role in melanocyte destruction in autoimmune vitiligo. Immunotherapy for melanoma often leads to autoimmune side-effects, among which vitiligo-like depigmentation, indicating that targeting immune checkpoints can break peripheral tolerance against self-antigens in the skin. Therapeutically enhancing immune checkpoint signaling by immune cells or skin cells, making self-reactive T cells anergic, seems a promising therapeutic option for vitiligo. Here, we review the current knowledge on the PD-1/PD-L1 pathway in vitiligo as new therapeutic target for vitiligo therapy.
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spelling doaj.art-259d75f634c448bc80266435ae8f11d22022-12-21T23:39:41ZengFrontiers Media S.A.Frontiers in Immunology1664-32242020-11-011110.3389/fimmu.2020.579022579022Targeting the PD-1/PD-L1 Axis in Human VitiligoMarcella Willemsen0Cornelis J. M. Melief1Marcel W. Bekkenk2Rosalie M. Luiten3Department of Dermatology and Netherlands Institute for Pigment Disorders, Amsterdam University Medical Centers, location AMC, University of Amsterdam, Cancer Center Amsterdam, Amsterdam Infection & Immunity Institute, Amsterdam, NetherlandsISA Pharmaceuticals, Leiden, NetherlandsDepartment of Dermatology and Netherlands Institute for Pigment Disorders, Amsterdam University Medical Centers, location AMC, University of Amsterdam, Cancer Center Amsterdam, Amsterdam Infection & Immunity Institute, Amsterdam, NetherlandsDepartment of Dermatology and Netherlands Institute for Pigment Disorders, Amsterdam University Medical Centers, location AMC, University of Amsterdam, Cancer Center Amsterdam, Amsterdam Infection & Immunity Institute, Amsterdam, NetherlandsAutoreactive CD8+ T cells play a pivotal role in melanocyte destruction in autoimmune vitiligo. Immunotherapy for melanoma often leads to autoimmune side-effects, among which vitiligo-like depigmentation, indicating that targeting immune checkpoints can break peripheral tolerance against self-antigens in the skin. Therapeutically enhancing immune checkpoint signaling by immune cells or skin cells, making self-reactive T cells anergic, seems a promising therapeutic option for vitiligo. Here, we review the current knowledge on the PD-1/PD-L1 pathway in vitiligo as new therapeutic target for vitiligo therapy.https://www.frontiersin.org/articles/10.3389/fimmu.2020.579022/fullvitiligoprogrammed cell death 1 receptorB7-H1 antigenimmune toleranceautoimmunity
spellingShingle Marcella Willemsen
Cornelis J. M. Melief
Marcel W. Bekkenk
Rosalie M. Luiten
Targeting the PD-1/PD-L1 Axis in Human Vitiligo
Frontiers in Immunology
vitiligo
programmed cell death 1 receptor
B7-H1 antigen
immune tolerance
autoimmunity
title Targeting the PD-1/PD-L1 Axis in Human Vitiligo
title_full Targeting the PD-1/PD-L1 Axis in Human Vitiligo
title_fullStr Targeting the PD-1/PD-L1 Axis in Human Vitiligo
title_full_unstemmed Targeting the PD-1/PD-L1 Axis in Human Vitiligo
title_short Targeting the PD-1/PD-L1 Axis in Human Vitiligo
title_sort targeting the pd 1 pd l1 axis in human vitiligo
topic vitiligo
programmed cell death 1 receptor
B7-H1 antigen
immune tolerance
autoimmunity
url https://www.frontiersin.org/articles/10.3389/fimmu.2020.579022/full
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AT rosaliemluiten targetingthepd1pdl1axisinhumanvitiligo