Advances in establishment and analysis of three-dimensional tumor spheroid-based functional assays for target validation and drug evaluation

Advances in establishment and analysis of three-dimensional tumor spheroid-based functional assays for target validation and drug evaluation

<p>Abstract</p> <p>Background</p> <p>There is overwhelming evidence that <it>in vitro </it>three-dimensional tumor cell cultures more accurately reflect the complex <it>in vivo </it>microenvironment than simple two-dimensional cell monolayers, no...

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Bibliographic Details
Main Authors: Vinci Maria, Gowan Sharon, Boxall Frances, Patterson Lisa, Zimmermann Miriam, Court William, Lomas Cara, Mendiola Marta, Hardisson David, Eccles Suzanne A
Format: Article
Language:English
Published: BMC 2012-03-01
Series:BMC Biology
Subjects:
3D
angiogenesis
drug response
high throughput
invasion
migration
tumor spheroids
Online Access:http://www.biomedcentral.com/1741-7007/10/29

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