Effects of Exercise on Cardiac Function Outcomes in Women Receiving Anthracycline or Trastuzumab Treatment for Breast Cancer: A Systematic Review and Meta-Analysis
Background: we conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) to evaluate the efficacy of exercise training on cardiac function and circulating biomarkers outcomes among women with breast cancer (BC) receiving anthracycline or trastuzumab-containing therapy. M...
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| Format: | Article |
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MDPI AG
2021-09-01
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| Online Access: | https://www.mdpi.com/2076-3417/11/18/8336 |
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| author | Pedro Antunes Dulce Esteves Célia Nunes Anabela Amarelo José Fonseca-Moutinho Vera Afreixo Henrique Costa Alberto Alves Ana Joaquim |
| author_facet | Pedro Antunes Dulce Esteves Célia Nunes Anabela Amarelo José Fonseca-Moutinho Vera Afreixo Henrique Costa Alberto Alves Ana Joaquim |
| author_sort | Pedro Antunes |
| collection | DOAJ |
| description | Background: we conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) to evaluate the efficacy of exercise training on cardiac function and circulating biomarkers outcomes among women with breast cancer (BC) receiving anthracycline or trastuzumab-containing therapy. Methods: PubMed, EMBASE, Cochrane Library, Web of Science and Scopus were searched. The primary outcome was change on left ventricular ejection fraction (LVEF). Secondary outcomes included diastolic function, strain imaging and circulating biomarkers. Results: Four RCTs were included, of those three were conducted during anthracycline and one during trastuzumab, involving 161 patients. All trials provided absolute change in LVEF (%) after a short to medium-term of treatment exposure (≤6 months). Pooled data revealed no differences in LVEF in the exercise group versus control [mean difference (MD): 2.07%; 95% CI: −0.17 to 4.34]. Similar results were observed by pooling data from the three RCTs conducted during anthracycline. Data from trials that implemented interventions with ≥36 exercise sessions (<i>n</i> = 3) showed a significant effect in preventing LVEF decline favoring the exercise (MD: 3.25%; 95% CI: 1.20 to 5.31). No significant changes were observed on secondary outcomes. Conclusions: exercise appears to have a beneficial effect in mitigating LVEF decline and this effect was significant for interventions with ≥36 exercise sessions. |
| first_indexed | 2024-03-10T07:55:51Z |
| format | Article |
| id | doaj.art-25a0e04315074247bde7a2cf2b67a07e |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-10T07:55:51Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-25a0e04315074247bde7a2cf2b67a07e2023-11-22T11:51:07ZengMDPI AGApplied Sciences2076-34172021-09-011118833610.3390/app11188336Effects of Exercise on Cardiac Function Outcomes in Women Receiving Anthracycline or Trastuzumab Treatment for Breast Cancer: A Systematic Review and Meta-AnalysisPedro Antunes0Dulce Esteves1Célia Nunes2Anabela Amarelo3José Fonseca-Moutinho4Vera Afreixo5Henrique Costa6Alberto Alves7Ana Joaquim8Research Center in Sport Sciences, Health and Human Development, CIDESD, University of Beira Interior, 6201-001 Covilhã, PortugalResearch Center in Sport Sciences, Health and Human Development, CIDESD, University of Beira Interior, 6201-001 Covilhã, PortugalDepartment of Mathematics and Center of Mathematics and Applications, University of Beira Interior, 6201-001 Covilhã, PortugalAssociação de Investigação de Cuidados de Suporte em Oncologia (AICSO), 4410-406 Vila Nova de Gaia, PortugalFaculty of Health Sciences, University of Beira Interior, 6201-001 Covilhã, PortugalCIDMA—Center for Research and Development in Mathematics and Applications, University of Aveiro, 3810-193 Aveiro, PortugalPsychiatry and Mental Health Department, Centro Hospitalar de Setúbal, 2190-446 Setúbal, PortugalAssociação de Investigação de Cuidados de Suporte em Oncologia (AICSO), 4410-406 Vila Nova de Gaia, PortugalAssociação de Investigação de Cuidados de Suporte em Oncologia (AICSO), 4410-406 Vila Nova de Gaia, PortugalBackground: we conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) to evaluate the efficacy of exercise training on cardiac function and circulating biomarkers outcomes among women with breast cancer (BC) receiving anthracycline or trastuzumab-containing therapy. Methods: PubMed, EMBASE, Cochrane Library, Web of Science and Scopus were searched. The primary outcome was change on left ventricular ejection fraction (LVEF). Secondary outcomes included diastolic function, strain imaging and circulating biomarkers. Results: Four RCTs were included, of those three were conducted during anthracycline and one during trastuzumab, involving 161 patients. All trials provided absolute change in LVEF (%) after a short to medium-term of treatment exposure (≤6 months). Pooled data revealed no differences in LVEF in the exercise group versus control [mean difference (MD): 2.07%; 95% CI: −0.17 to 4.34]. Similar results were observed by pooling data from the three RCTs conducted during anthracycline. Data from trials that implemented interventions with ≥36 exercise sessions (<i>n</i> = 3) showed a significant effect in preventing LVEF decline favoring the exercise (MD: 3.25%; 95% CI: 1.20 to 5.31). No significant changes were observed on secondary outcomes. Conclusions: exercise appears to have a beneficial effect in mitigating LVEF decline and this effect was significant for interventions with ≥36 exercise sessions.https://www.mdpi.com/2076-3417/11/18/8336breast cancercardiac functioncardiotoxicityexercise |
| spellingShingle | Pedro Antunes Dulce Esteves Célia Nunes Anabela Amarelo José Fonseca-Moutinho Vera Afreixo Henrique Costa Alberto Alves Ana Joaquim Effects of Exercise on Cardiac Function Outcomes in Women Receiving Anthracycline or Trastuzumab Treatment for Breast Cancer: A Systematic Review and Meta-Analysis Applied Sciences breast cancer cardiac function cardiotoxicity exercise |
| title | Effects of Exercise on Cardiac Function Outcomes in Women Receiving Anthracycline or Trastuzumab Treatment for Breast Cancer: A Systematic Review and Meta-Analysis |
| title_full | Effects of Exercise on Cardiac Function Outcomes in Women Receiving Anthracycline or Trastuzumab Treatment for Breast Cancer: A Systematic Review and Meta-Analysis |
| title_fullStr | Effects of Exercise on Cardiac Function Outcomes in Women Receiving Anthracycline or Trastuzumab Treatment for Breast Cancer: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Effects of Exercise on Cardiac Function Outcomes in Women Receiving Anthracycline or Trastuzumab Treatment for Breast Cancer: A Systematic Review and Meta-Analysis |
| title_short | Effects of Exercise on Cardiac Function Outcomes in Women Receiving Anthracycline or Trastuzumab Treatment for Breast Cancer: A Systematic Review and Meta-Analysis |
| title_sort | effects of exercise on cardiac function outcomes in women receiving anthracycline or trastuzumab treatment for breast cancer a systematic review and meta analysis |
| topic | breast cancer cardiac function cardiotoxicity exercise |
| url | https://www.mdpi.com/2076-3417/11/18/8336 |
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