Prescribing patterns of coronary artery aneurysm in Taiwan
Abstract Background Coronary artery aneurysm (CAA) is a rare disease, and there are limited data on prescribing patterns for CAA. The aim of our study was to investigate prescribing patterns for CAA in Taiwan via the National Health Insurance Research Database (NHIRD). Methods We included all CAA pa...
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| Format: | Article |
| Language: | English |
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BMC
2019-08-01
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| Series: | BMC Cardiovascular Disorders |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12872-019-1172-6 |
| _version_ | 1819085026208251904 |
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| author | Chun-Hui Lu Chih-Wun Fang Hao-Ming Chen Yi-Ping Fang Chein-Tang Fang Yaw-Bin Huang Chung-Yu Chen Kuang-Ming Liao Shu-Chuan Jennifer Yeh |
| author_facet | Chun-Hui Lu Chih-Wun Fang Hao-Ming Chen Yi-Ping Fang Chein-Tang Fang Yaw-Bin Huang Chung-Yu Chen Kuang-Ming Liao Shu-Chuan Jennifer Yeh |
| author_sort | Chun-Hui Lu |
| collection | DOAJ |
| description | Abstract Background Coronary artery aneurysm (CAA) is a rare disease, and there are limited data on prescribing patterns for CAA. The aim of our study was to investigate prescribing patterns for CAA in Taiwan via the National Health Insurance Research Database (NHIRD). Methods We included all CAA patients in Taiwan from 2005 to 2011. Data from 1 year before and after the CAA diagnosis were used to analyze examinations, comorbidities and prescribing patterns. Results A total of 1397 patients diagnosed with CAA were enrolled in our study. Most pediatric patients with CAA were diagnosed with Kawasaki disease (95.7%). In pediatric CAA patients, the utilization rates of aspirin and gamma globulins were 82.9 and 53.6%, respectively, after CAA diagnosis. Among the antithrombotic agents, aspirin was used most commonly, followed by dipyridamole (16.9%), heparin (5.8%) and warfarin (4.6%). In adult CAA patients, common comorbidities included hypertension (63.4%), hyperlipidemia (39.6%), and diabetes mellitus (26.1%). Coronary atherosclerosis was identified in 72.5% of adult patients after CAA diagnosis. Antithrombotic agents, particularly aspirin, clopidogrel and heparin, were prescribed more frequently after CAA diagnosis. Among the prescribed medications, aspirin (75.8%), β-blockers (48.3%), statins (47.6%), metformin (14.4%), sulfonylureas (14.4%) and isosorbide mononitrate (32.9%) were frequently observed in each category. Conclusions Kawasaki disease was the main cause of CAA in pediatric patients, and coronary artery disease was the most common comorbidity in adult CAA patients. The most commonly used antithrombic agent after CAA diagnosis was aspirin in both adult and pediatric patients. |
| first_indexed | 2024-12-21T20:57:48Z |
| format | Article |
| id | doaj.art-25a0f4269a9c4d058f0e0a10c5eab67c |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-12-21T20:57:48Z |
| publishDate | 2019-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-25a0f4269a9c4d058f0e0a10c5eab67c2022-12-21T18:50:32ZengBMCBMC Cardiovascular Disorders1471-22612019-08-011911910.1186/s12872-019-1172-6Prescribing patterns of coronary artery aneurysm in TaiwanChun-Hui Lu0Chih-Wun Fang1Hao-Ming Chen2Yi-Ping Fang3Chein-Tang Fang4Yaw-Bin Huang5Chung-Yu Chen6Kuang-Ming Liao7Shu-Chuan Jennifer Yeh8Division of Pharmacy, Zuoying Branch of Kaohsiung Armed Forces General HospitalDivision of Pharmacy, Zuoying Branch of Kaohsiung Armed Forces General HospitalDivision of Pharmacy, Zuoying Branch of Kaohsiung Armed Forces General HospitalSchool of Pharmacy, Kaohsiung Medical UniversitySchool of Pharmacy, Kaohsiung Medical UniversitySchool of Pharmacy, Kaohsiung Medical UniversitySchool of Pharmacy, Kaohsiung Medical UniversityDepartment of Internal Medicine, Chi Mei Medical Center, ChialiDepartment of Business Management, National Sun Yat-sen UniversityAbstract Background Coronary artery aneurysm (CAA) is a rare disease, and there are limited data on prescribing patterns for CAA. The aim of our study was to investigate prescribing patterns for CAA in Taiwan via the National Health Insurance Research Database (NHIRD). Methods We included all CAA patients in Taiwan from 2005 to 2011. Data from 1 year before and after the CAA diagnosis were used to analyze examinations, comorbidities and prescribing patterns. Results A total of 1397 patients diagnosed with CAA were enrolled in our study. Most pediatric patients with CAA were diagnosed with Kawasaki disease (95.7%). In pediatric CAA patients, the utilization rates of aspirin and gamma globulins were 82.9 and 53.6%, respectively, after CAA diagnosis. Among the antithrombotic agents, aspirin was used most commonly, followed by dipyridamole (16.9%), heparin (5.8%) and warfarin (4.6%). In adult CAA patients, common comorbidities included hypertension (63.4%), hyperlipidemia (39.6%), and diabetes mellitus (26.1%). Coronary atherosclerosis was identified in 72.5% of adult patients after CAA diagnosis. Antithrombotic agents, particularly aspirin, clopidogrel and heparin, were prescribed more frequently after CAA diagnosis. Among the prescribed medications, aspirin (75.8%), β-blockers (48.3%), statins (47.6%), metformin (14.4%), sulfonylureas (14.4%) and isosorbide mononitrate (32.9%) were frequently observed in each category. Conclusions Kawasaki disease was the main cause of CAA in pediatric patients, and coronary artery disease was the most common comorbidity in adult CAA patients. The most commonly used antithrombic agent after CAA diagnosis was aspirin in both adult and pediatric patients.http://link.springer.com/article/10.1186/s12872-019-1172-6ComorbiditiesCoronary artery aneurysmPrescribing pattern |
| spellingShingle | Chun-Hui Lu Chih-Wun Fang Hao-Ming Chen Yi-Ping Fang Chein-Tang Fang Yaw-Bin Huang Chung-Yu Chen Kuang-Ming Liao Shu-Chuan Jennifer Yeh Prescribing patterns of coronary artery aneurysm in Taiwan BMC Cardiovascular Disorders Comorbidities Coronary artery aneurysm Prescribing pattern |
| title | Prescribing patterns of coronary artery aneurysm in Taiwan |
| title_full | Prescribing patterns of coronary artery aneurysm in Taiwan |
| title_fullStr | Prescribing patterns of coronary artery aneurysm in Taiwan |
| title_full_unstemmed | Prescribing patterns of coronary artery aneurysm in Taiwan |
| title_short | Prescribing patterns of coronary artery aneurysm in Taiwan |
| title_sort | prescribing patterns of coronary artery aneurysm in taiwan |
| topic | Comorbidities Coronary artery aneurysm Prescribing pattern |
| url | http://link.springer.com/article/10.1186/s12872-019-1172-6 |
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