Structural, Spectroscopic, and Biological Characterization of Novel Rubidium(I) and Europium(III) Co-Doped Nano-Hydroxyapatite Materials and Their Potential Use in Regenerative Medicine
This research investigates hydrothermally synthesized hydroxyapatite nanoparticles doped with rubidium(I) and europium(III) ions. Investigation focused on establishing the influence of co-doped Eu<sup>3+</sup> and Rb<sup>+</sup> ions on hydroxyapatite lattice. Therefore, stru...
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| Format: | Article |
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MDPI AG
2022-12-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/12/24/4475 |
| _version_ | 1797455911383465984 |
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| author | Nicole Nowak Dominika Czekanowska John M. Reeks Rafal J. Wiglusz |
| author_facet | Nicole Nowak Dominika Czekanowska John M. Reeks Rafal J. Wiglusz |
| author_sort | Nicole Nowak |
| collection | DOAJ |
| description | This research investigates hydrothermally synthesized hydroxyapatite nanoparticles doped with rubidium(I) and europium(III) ions. Investigation focused on establishing the influence of co-doped Eu<sup>3+</sup> and Rb<sup>+</sup> ions on hydroxyapatite lattice. Therefore, structural, and morphological properties were characterized via using X-ray powder diffraction (XRPD), infrared spectroscopy (FT-IR), and scanning electron microscopy (SEM), as well as transmission electron microscopy (TEM) techniques. Furthermore, this investigation evaluates the impact of various Rb<sup>+</sup> ion doping concentrations on the distinct red emission of co-doped Eu<sup>3+</sup> ions. Hence, luminescence properties of the obtained materials were evaluated by measuring emission excitation, emission spectra, and luminescence decays. As established by numerous studies, synthetic hydroxyapatite has excellent application in biomedical field, as it is fully biocompatible. Its biocompatible makes it highly useful in the biomedical field as a bone fracture filler or hydroxyapatite coated dental implant. By the incorporation of Eu<sup>3+</sup> ions and Rb<sup>+</sup> ions we established the impact these co-doped ions have on the biocompatibility of hydroxyapatite powders. Therefore, biocompatibility toward a ram’s red blood cells was evaluated to exclude potential cytotoxic features of the synthesized compounds. Additionally, experimental in vitro bioactive properties of hydroxyapatite nanoparticles doped with Rb<sup>+</sup> and Eu<sup>3+</sup> ions were established using a mouse osteoblast model. These properties are discussed in detail as they contribute to a novel method in regenerative medicine. |
| first_indexed | 2024-03-09T16:01:01Z |
| format | Article |
| id | doaj.art-25a1a35fe62c419ba6876dbb4654a1a1 |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-09T16:01:01Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-25a1a35fe62c419ba6876dbb4654a1a12023-11-24T17:05:00ZengMDPI AGNanomaterials2079-49912022-12-011224447510.3390/nano12244475Structural, Spectroscopic, and Biological Characterization of Novel Rubidium(I) and Europium(III) Co-Doped Nano-Hydroxyapatite Materials and Their Potential Use in Regenerative MedicineNicole Nowak0Dominika Czekanowska1John M. Reeks2Rafal J. Wiglusz3Institute of Low Temperature and Structure Research, Polish Academy of Sciences, Okolna 2, 50-422 Wroclaw, PolandInstitute of Low Temperature and Structure Research, Polish Academy of Sciences, Okolna 2, 50-422 Wroclaw, PolandInstitute of Low Temperature and Structure Research, Polish Academy of Sciences, Okolna 2, 50-422 Wroclaw, PolandInstitute of Low Temperature and Structure Research, Polish Academy of Sciences, Okolna 2, 50-422 Wroclaw, PolandThis research investigates hydrothermally synthesized hydroxyapatite nanoparticles doped with rubidium(I) and europium(III) ions. Investigation focused on establishing the influence of co-doped Eu<sup>3+</sup> and Rb<sup>+</sup> ions on hydroxyapatite lattice. Therefore, structural, and morphological properties were characterized via using X-ray powder diffraction (XRPD), infrared spectroscopy (FT-IR), and scanning electron microscopy (SEM), as well as transmission electron microscopy (TEM) techniques. Furthermore, this investigation evaluates the impact of various Rb<sup>+</sup> ion doping concentrations on the distinct red emission of co-doped Eu<sup>3+</sup> ions. Hence, luminescence properties of the obtained materials were evaluated by measuring emission excitation, emission spectra, and luminescence decays. As established by numerous studies, synthetic hydroxyapatite has excellent application in biomedical field, as it is fully biocompatible. Its biocompatible makes it highly useful in the biomedical field as a bone fracture filler or hydroxyapatite coated dental implant. By the incorporation of Eu<sup>3+</sup> ions and Rb<sup>+</sup> ions we established the impact these co-doped ions have on the biocompatibility of hydroxyapatite powders. Therefore, biocompatibility toward a ram’s red blood cells was evaluated to exclude potential cytotoxic features of the synthesized compounds. Additionally, experimental in vitro bioactive properties of hydroxyapatite nanoparticles doped with Rb<sup>+</sup> and Eu<sup>3+</sup> ions were established using a mouse osteoblast model. These properties are discussed in detail as they contribute to a novel method in regenerative medicine.https://www.mdpi.com/2079-4991/12/24/4475nanosized hydroxyapatiteEu<sup>3+</sup> ion-dopingRb<sup>+</sup> ion-dopingregenerative medicinetissue engineeringphotoluminescence |
| spellingShingle | Nicole Nowak Dominika Czekanowska John M. Reeks Rafal J. Wiglusz Structural, Spectroscopic, and Biological Characterization of Novel Rubidium(I) and Europium(III) Co-Doped Nano-Hydroxyapatite Materials and Their Potential Use in Regenerative Medicine Nanomaterials nanosized hydroxyapatite Eu<sup>3+</sup> ion-doping Rb<sup>+</sup> ion-doping regenerative medicine tissue engineering photoluminescence |
| title | Structural, Spectroscopic, and Biological Characterization of Novel Rubidium(I) and Europium(III) Co-Doped Nano-Hydroxyapatite Materials and Their Potential Use in Regenerative Medicine |
| title_full | Structural, Spectroscopic, and Biological Characterization of Novel Rubidium(I) and Europium(III) Co-Doped Nano-Hydroxyapatite Materials and Their Potential Use in Regenerative Medicine |
| title_fullStr | Structural, Spectroscopic, and Biological Characterization of Novel Rubidium(I) and Europium(III) Co-Doped Nano-Hydroxyapatite Materials and Their Potential Use in Regenerative Medicine |
| title_full_unstemmed | Structural, Spectroscopic, and Biological Characterization of Novel Rubidium(I) and Europium(III) Co-Doped Nano-Hydroxyapatite Materials and Their Potential Use in Regenerative Medicine |
| title_short | Structural, Spectroscopic, and Biological Characterization of Novel Rubidium(I) and Europium(III) Co-Doped Nano-Hydroxyapatite Materials and Their Potential Use in Regenerative Medicine |
| title_sort | structural spectroscopic and biological characterization of novel rubidium i and europium iii co doped nano hydroxyapatite materials and their potential use in regenerative medicine |
| topic | nanosized hydroxyapatite Eu<sup>3+</sup> ion-doping Rb<sup>+</sup> ion-doping regenerative medicine tissue engineering photoluminescence |
| url | https://www.mdpi.com/2079-4991/12/24/4475 |
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