A dual dopaminergic therapy with L-3,4-dihydroxyphenylalanine and chlorpromazine for the treatment of blepharospasm, a focal dystonia: Possible implications for striosomal D1 signaling

A dual dopaminergic therapy with L-3,4-dihydroxyphenylalanine and chlorpromazine for the treatment of blepharospasm, a focal dystonia: Possible implications for striosomal D1 signaling

Impairment of balanced activity between dopamine D1 and D2 receptor functions in the striatum, particularly in striatal functional subdivisions (i.e., striosome and matrix compartments), has been proposed to underlie dystonia genesis. This study was undertaken to examine the therapeutic effect of du...

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Bibliographic Details
Main Authors: Shinichi Matsumoto, Hidetaka Koizumi, Hideki Shimazu, Ryuji Kaji, Satoshi Goto
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Neurology
Subjects:
blepharospasm
dystonia
L-DOPA
chlorpromazine
dopamine D1 receptor
striatum
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2022.922333/full

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