PIP2 regulation of KCNQ channels: biophysical and molecular mechanisms for lipid modulation of voltage-dependent gating
Voltage-gated potassium (Kv) channels contain voltage-sensing (VSD) and pore-gate (PGD) structural domains. During voltage-dependent gating, conformational changes in the two domains are coupled giving rise to voltage-dependent opening of the channel. In addition to membrane voltage, KCNQ (Kv7) chan...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-05-01
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| Series: | Frontiers in Physiology |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00195/full |
| _version_ | 1819052585427927040 |
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| author | Mark Alan Zaydman Jianmin eCui |
| author_facet | Mark Alan Zaydman Jianmin eCui |
| author_sort | Mark Alan Zaydman |
| collection | DOAJ |
| description | Voltage-gated potassium (Kv) channels contain voltage-sensing (VSD) and pore-gate (PGD) structural domains. During voltage-dependent gating, conformational changes in the two domains are coupled giving rise to voltage-dependent opening of the channel. In addition to membrane voltage, KCNQ (Kv7) channel opening requires the membrane lipid phosphatidylinositol 4,5-bisphosphate (PIP2). Recent studies suggest that PIP2 serves as a cofactor to mediate VSD-PGD coupling in KCNQ1 channels. In this review, we put these findings in the context of the current understanding of voltage-dependent gating, lipid modulation of Kv channel activation, and PIP2-regulation of KCNQ channels. We suggest that lipid-mediated coupling of functional domains is a common mechanism among KCNQ channels that may be applicable to other Kv channels and membrane proteins. |
| first_indexed | 2024-12-21T12:22:10Z |
| format | Article |
| id | doaj.art-25a38e288e4d48e185b254ec3d1a464a |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-21T12:22:10Z |
| publishDate | 2014-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-25a38e288e4d48e185b254ec3d1a464a2022-12-21T19:04:16ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2014-05-01510.3389/fphys.2014.0019586930PIP2 regulation of KCNQ channels: biophysical and molecular mechanisms for lipid modulation of voltage-dependent gatingMark Alan Zaydman0Jianmin eCui1Washington University in St LouisWashington University in St LouisVoltage-gated potassium (Kv) channels contain voltage-sensing (VSD) and pore-gate (PGD) structural domains. During voltage-dependent gating, conformational changes in the two domains are coupled giving rise to voltage-dependent opening of the channel. In addition to membrane voltage, KCNQ (Kv7) channel opening requires the membrane lipid phosphatidylinositol 4,5-bisphosphate (PIP2). Recent studies suggest that PIP2 serves as a cofactor to mediate VSD-PGD coupling in KCNQ1 channels. In this review, we put these findings in the context of the current understanding of voltage-dependent gating, lipid modulation of Kv channel activation, and PIP2-regulation of KCNQ channels. We suggest that lipid-mediated coupling of functional domains is a common mechanism among KCNQ channels that may be applicable to other Kv channels and membrane proteins.http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00195/fullKCNQion channelPIP2voltage-gatinglipid modulations |
| spellingShingle | Mark Alan Zaydman Jianmin eCui PIP2 regulation of KCNQ channels: biophysical and molecular mechanisms for lipid modulation of voltage-dependent gating Frontiers in Physiology KCNQ ion channel PIP2 voltage-gating lipid modulations |
| title | PIP2 regulation of KCNQ channels: biophysical and molecular mechanisms for lipid modulation of voltage-dependent gating |
| title_full | PIP2 regulation of KCNQ channels: biophysical and molecular mechanisms for lipid modulation of voltage-dependent gating |
| title_fullStr | PIP2 regulation of KCNQ channels: biophysical and molecular mechanisms for lipid modulation of voltage-dependent gating |
| title_full_unstemmed | PIP2 regulation of KCNQ channels: biophysical and molecular mechanisms for lipid modulation of voltage-dependent gating |
| title_short | PIP2 regulation of KCNQ channels: biophysical and molecular mechanisms for lipid modulation of voltage-dependent gating |
| title_sort | pip2 regulation of kcnq channels biophysical and molecular mechanisms for lipid modulation of voltage dependent gating |
| topic | KCNQ ion channel PIP2 voltage-gating lipid modulations |
| url | http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00195/full |
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