PIP2 regulation of KCNQ channels: biophysical and molecular mechanisms for lipid modulation of voltage-dependent gating

PIP2 regulation of KCNQ channels: biophysical and molecular mechanisms for lipid modulation of voltage-dependent gating

Voltage-gated potassium (Kv) channels contain voltage-sensing (VSD) and pore-gate (PGD) structural domains. During voltage-dependent gating, conformational changes in the two domains are coupled giving rise to voltage-dependent opening of the channel. In addition to membrane voltage, KCNQ (Kv7) chan...

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Bibliographic Details
Main Authors: Mark Alan Zaydman, Jianmin eCui
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-05-01
Series:Frontiers in Physiology
Subjects:
KCNQ
ion channel
PIP2
voltage-gating
lipid modulations
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00195/full

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