Pan-Cancer Analysis Reveals Alternative Splicing Characteristics Associated With Immune-Related Adverse Events Elicited by Checkpoint Immunotherapy

Pan-Cancer Analysis Reveals Alternative Splicing Characteristics Associated With Immune-Related Adverse Events Elicited by Checkpoint Immunotherapy

Immune-related adverse events (irAEs) can impair the effectiveness and safety of immune checkpoint inhibitors (ICIs) and restrict the clinical applications of ICIs in oncology. The predictive biomarkers of irAE are urgently required for early diagnosis and subsequent management. The exact mechanism...

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Bibliographic Details
Main Authors:	Xiujing He, Jing Yu, Hubing Shi
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-11-01
Series:	Frontiers in Pharmacology
Subjects:	immune-related adverse events immune checkpoint inhibitors cancer immunotherapy alternative splicing splicing isoforms
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2021.797852/full

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