The concept of radiation-enhanced stem cell differentiation
Background. Efficient stem cell differentiation is considered to be the holy grail of regenerative medicine. Pursuing the most productive method of directed differentiation has been the subject of numerous studies, resulting in the development of many effective protocols. However, the necessity for...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Sciendo
2015-09-01
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| Series: | Radiology and Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/raon-2015-0022 |
| _version_ | 1818718238469521408 |
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| author | Mieloch Adam A. Suchorska Wiktoria M. |
| author_facet | Mieloch Adam A. Suchorska Wiktoria M. |
| author_sort | Mieloch Adam A. |
| collection | DOAJ |
| description | Background. Efficient stem cell differentiation is considered to be the holy grail of regenerative medicine. Pursuing the most productive method of directed differentiation has been the subject of numerous studies, resulting in the development of many effective protocols. However, the necessity for further improvement in differentiation efficiency remains. This review contains a description of molecular processes underlying the response of stem cells to ionizing radiation, indicating its potential application in differentiation procedures. In the first part, the radiation-induced damage response in various types of stem cells is described. Second, the role of the p53 protein in embryonic and adult stem cells is highlighted. Last, the hypothesis on the mitochondrial involvement in stem cell development including its response to ionizing radiation is presented. |
| first_indexed | 2024-12-17T19:47:52Z |
| format | Article |
| id | doaj.art-25a5c229dd944bd7beef3e6d36c79234 |
| institution | Directory Open Access Journal |
| issn | 1581-3207 |
| language | English |
| last_indexed | 2024-12-17T19:47:52Z |
| publishDate | 2015-09-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Radiology and Oncology |
| spelling | doaj.art-25a5c229dd944bd7beef3e6d36c792342022-12-21T21:34:49ZengSciendoRadiology and Oncology1581-32072015-09-0149320921610.1515/raon-2015-0022raon-2015-0022The concept of radiation-enhanced stem cell differentiationMieloch Adam A.0Suchorska Wiktoria M.1Radiobiology Laboratory, Department of Medical Physics, The Greater Poland Cancer CentreRadiobiology Laboratory, Department of Medical Physics, The Greater Poland Cancer CentreBackground. Efficient stem cell differentiation is considered to be the holy grail of regenerative medicine. Pursuing the most productive method of directed differentiation has been the subject of numerous studies, resulting in the development of many effective protocols. However, the necessity for further improvement in differentiation efficiency remains. This review contains a description of molecular processes underlying the response of stem cells to ionizing radiation, indicating its potential application in differentiation procedures. In the first part, the radiation-induced damage response in various types of stem cells is described. Second, the role of the p53 protein in embryonic and adult stem cells is highlighted. Last, the hypothesis on the mitochondrial involvement in stem cell development including its response to ionizing radiation is presented.https://doi.org/10.1515/raon-2015-0022stem cellsionizing radiationdifferentiationregenerative medicinetissue engineering |
| spellingShingle | Mieloch Adam A. Suchorska Wiktoria M. The concept of radiation-enhanced stem cell differentiation Radiology and Oncology stem cells ionizing radiation differentiation regenerative medicine tissue engineering |
| title | The concept of radiation-enhanced stem cell differentiation |
| title_full | The concept of radiation-enhanced stem cell differentiation |
| title_fullStr | The concept of radiation-enhanced stem cell differentiation |
| title_full_unstemmed | The concept of radiation-enhanced stem cell differentiation |
| title_short | The concept of radiation-enhanced stem cell differentiation |
| title_sort | concept of radiation enhanced stem cell differentiation |
| topic | stem cells ionizing radiation differentiation regenerative medicine tissue engineering |
| url | https://doi.org/10.1515/raon-2015-0022 |
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