Comparison of typical and atypical computed tomography patterns regarding reversibility and fibrosis in pulmonary sarcoidosis
PURPOSE: This study aims to investigate whether there is a significant difference between typical and atypical parenchymal patterns in the development of fibrosis, which is the most crucial factor affecting morbidity in pulmonary sarcoidosis. METHODS: In our hospital, 145 cases with Siltzbach Types...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2021-01-01
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| Series: | Annals of Thoracic Medicine |
| Subjects: | |
| Online Access: | http://www.thoracicmedicine.org/article.asp?issn=1817-1737;year=2021;volume=16;issue=1;spage=118;epage=125;aulast=Susam |
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| author | Seher Susam Fatma Demirci Ucsular Enver Yalniz Akin Cinkooglu Gulru Polat Berna Eren Komurcuoglu Ceyda Anar Gulistan Karadeniz Ali Kadri Cirak Emel Tellioglu Filiz Guldaval Mine Gayaf Nimet Aksel Ozgur Batum Dursun Alizoroglu Semra Bilaceroglu |
| author_facet | Seher Susam Fatma Demirci Ucsular Enver Yalniz Akin Cinkooglu Gulru Polat Berna Eren Komurcuoglu Ceyda Anar Gulistan Karadeniz Ali Kadri Cirak Emel Tellioglu Filiz Guldaval Mine Gayaf Nimet Aksel Ozgur Batum Dursun Alizoroglu Semra Bilaceroglu |
| author_sort | Seher Susam |
| collection | DOAJ |
| description | PURPOSE: This study aims to investigate whether there is a significant difference between typical and atypical parenchymal patterns in the development of fibrosis, which is the most crucial factor affecting morbidity in pulmonary sarcoidosis.
METHODS: In our hospital, 145 cases with Siltzbach Types 2 and 3 sarcoidoses diagnosed by clinical, radiological, and histopathologic were retrospectively investigated. Perilymphatic nodules, accompanying mosaic attenuation, and interlobular septal thickening and central peribronchovascular bunch-like thickening on high-resolution computed tomography were assessed as typical. Solid nodules, galaxy finding, consolidation, ground-glass opacity, isolated mosaic attenuation, and interlobular septal thickening, and pleural fluid were accepted as atypical findings. Findings indicating fibrosis were fine and rough reticular opacity, traction bronchiectasis, volume loss, and cystic changes. For the analysis of variables, SPSS 25.0 program was used.
RESULTS: Ten (16%) of the 61 cases with typical findings and 16 (19%) of the 84 with atypical findings developed fibrosis (P = 0.827). The mean age of cases with fibrosis was higher. With the cut-off of 50 years, sensitivity was 61.5%, and specificity was 68.9%. The highest fibrosis rate was in cases with ground glass pattern (n = 7/17), whereas higher reversibility rates were in those with miliary pattern (n = 9/12) and galaxy sign (n = 5/6).
CONCLUSION: The incidence of fibrosis is higher in the atypical group with no significant difference. The incidence of fibrosis differs in each atypical pattern, being highest in ground-glass opacity and lowest in the miliary pattern. |
| first_indexed | 2024-12-22T06:08:47Z |
| format | Article |
| id | doaj.art-25a71fd44d0147b5ad07aca0684fcf0f |
| institution | Directory Open Access Journal |
| issn | 1817-1737 1998-3557 |
| language | English |
| last_indexed | 2024-12-22T06:08:47Z |
| publishDate | 2021-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Annals of Thoracic Medicine |
| spelling | doaj.art-25a71fd44d0147b5ad07aca0684fcf0f2022-12-21T18:36:17ZengWolters Kluwer Medknow PublicationsAnnals of Thoracic Medicine1817-17371998-35572021-01-0116111812510.4103/atm.ATM_187_20Comparison of typical and atypical computed tomography patterns regarding reversibility and fibrosis in pulmonary sarcoidosisSeher SusamFatma Demirci UcsularEnver YalnizAkin CinkoogluGulru PolatBerna Eren KomurcuogluCeyda AnarGulistan KaradenizAli Kadri CirakEmel TelliogluFiliz GuldavalMine GayafNimet AkselOzgur BatumDursun AlizorogluSemra BilacerogluPURPOSE: This study aims to investigate whether there is a significant difference between typical and atypical parenchymal patterns in the development of fibrosis, which is the most crucial factor affecting morbidity in pulmonary sarcoidosis. METHODS: In our hospital, 145 cases with Siltzbach Types 2 and 3 sarcoidoses diagnosed by clinical, radiological, and histopathologic were retrospectively investigated. Perilymphatic nodules, accompanying mosaic attenuation, and interlobular septal thickening and central peribronchovascular bunch-like thickening on high-resolution computed tomography were assessed as typical. Solid nodules, galaxy finding, consolidation, ground-glass opacity, isolated mosaic attenuation, and interlobular septal thickening, and pleural fluid were accepted as atypical findings. Findings indicating fibrosis were fine and rough reticular opacity, traction bronchiectasis, volume loss, and cystic changes. For the analysis of variables, SPSS 25.0 program was used. RESULTS: Ten (16%) of the 61 cases with typical findings and 16 (19%) of the 84 with atypical findings developed fibrosis (P = 0.827). The mean age of cases with fibrosis was higher. With the cut-off of 50 years, sensitivity was 61.5%, and specificity was 68.9%. The highest fibrosis rate was in cases with ground glass pattern (n = 7/17), whereas higher reversibility rates were in those with miliary pattern (n = 9/12) and galaxy sign (n = 5/6). CONCLUSION: The incidence of fibrosis is higher in the atypical group with no significant difference. The incidence of fibrosis differs in each atypical pattern, being highest in ground-glass opacity and lowest in the miliary pattern.http://www.thoracicmedicine.org/article.asp?issn=1817-1737;year=2021;volume=16;issue=1;spage=118;epage=125;aulast=Susamatypicalcomputed tomographyfibrosispulmonarysarcoidosistypical |
| spellingShingle | Seher Susam Fatma Demirci Ucsular Enver Yalniz Akin Cinkooglu Gulru Polat Berna Eren Komurcuoglu Ceyda Anar Gulistan Karadeniz Ali Kadri Cirak Emel Tellioglu Filiz Guldaval Mine Gayaf Nimet Aksel Ozgur Batum Dursun Alizoroglu Semra Bilaceroglu Comparison of typical and atypical computed tomography patterns regarding reversibility and fibrosis in pulmonary sarcoidosis Annals of Thoracic Medicine atypical computed tomography fibrosis pulmonary sarcoidosis typical |
| title | Comparison of typical and atypical computed tomography patterns regarding reversibility and fibrosis in pulmonary sarcoidosis |
| title_full | Comparison of typical and atypical computed tomography patterns regarding reversibility and fibrosis in pulmonary sarcoidosis |
| title_fullStr | Comparison of typical and atypical computed tomography patterns regarding reversibility and fibrosis in pulmonary sarcoidosis |
| title_full_unstemmed | Comparison of typical and atypical computed tomography patterns regarding reversibility and fibrosis in pulmonary sarcoidosis |
| title_short | Comparison of typical and atypical computed tomography patterns regarding reversibility and fibrosis in pulmonary sarcoidosis |
| title_sort | comparison of typical and atypical computed tomography patterns regarding reversibility and fibrosis in pulmonary sarcoidosis |
| topic | atypical computed tomography fibrosis pulmonary sarcoidosis typical |
| url | http://www.thoracicmedicine.org/article.asp?issn=1817-1737;year=2021;volume=16;issue=1;spage=118;epage=125;aulast=Susam |
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