Number of Attending Physicians and Accumulated Organ Damage in Patients with Systemic Lupus Erythematosus: LUNA Registry Cross-Sectional Study
Abstract Introduction Patients with systemic lupus erythematosus (SLE) frequently change attending physicians. The number of changes in attending physicians is related to the accumulated organ damage in patients with diabetes mellitus and inflammatory bowel disease, although similar results are not...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Adis, Springer Healthcare
2023-01-01
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| Series: | Rheumatology and Therapy |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s40744-022-00528-8 |
| _version_ | 1797863590125895680 |
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| author | Ryo Yanai Nobuyuki Yajima Nao Oguro Yasuhiro Shimojima Shigeru Ohno Hiroshi Kajiyama Kunihiro Ichinose Shuzo Sato Michio Fujiwara Yoshia Miyawaki Ryusuke Yoshimi Takashi Kida Yusuke Matsuo Keisuke Nishimura Ken-ei Sada |
| author_facet | Ryo Yanai Nobuyuki Yajima Nao Oguro Yasuhiro Shimojima Shigeru Ohno Hiroshi Kajiyama Kunihiro Ichinose Shuzo Sato Michio Fujiwara Yoshia Miyawaki Ryusuke Yoshimi Takashi Kida Yusuke Matsuo Keisuke Nishimura Ken-ei Sada |
| author_sort | Ryo Yanai |
| collection | DOAJ |
| description | Abstract Introduction Patients with systemic lupus erythematosus (SLE) frequently change attending physicians. The number of changes in attending physicians is related to the accumulated organ damage in patients with diabetes mellitus and inflammatory bowel disease, although similar results are not known for patients with SLE. This study investigated whether the number of attending physicians after the onset of SLE is associated with organ damage. Methods Patients with SLE were enrolled in a multicenter registry of 14 institutions (the Lupus Registry of Nationwide Institutions). Patients with a disease duration of 6 months to 10 years were included. Exposure was defined as the number of attending physicians. The primary outcome was the Systemic Lupus International Collaborating Clinics/American College of Rheumatology damage index (SDI). The secondary outcomes were corticosteroid- and non-corticosteroid-related damage. Multiple logistic regression analysis was used to estimate the association between the number of attending physicians and SDI, adjusting for potential confounders, including age, sex, disease duration, number of hospitalizations due to SLE, disease activity at diagnosis, and emotional health. Results Of the 702 patients, 86.5% were women (median age 46 years, interquartile range 35–58). The disease duration was 7.3 years (4.3–11.3), the number of hospitalizations due to SLE was 1 (1–3), the number of attending physicians was 3 (2–4), and SDI was 0 points (0–1). The number of attending physicians was significantly associated with SDI [odds ratio (OR) 1.14, 95% confidence interval (CI) 1.03–1.26]. In the secondary outcome, the number of attending physicians was significantly associated with corticosteroid-related damage (OR 1.22, 95% CI 1.09–1.38). The number of attending physicians was not significantly associated with non-corticosteroid-related damage (OR 1.08, 95% CI 0.99–1.19). Conclusions This study showed that SDI could increase as the number of attending physicians increases. The impact of changing attending physicians warrants greater attention for SLE and other diseases. |
| first_indexed | 2024-04-09T22:37:55Z |
| format | Article |
| id | doaj.art-25a8d48089224c4788673035a327e06b |
| institution | Directory Open Access Journal |
| issn | 2198-6576 2198-6584 |
| language | English |
| last_indexed | 2024-04-09T22:37:55Z |
| publishDate | 2023-01-01 |
| publisher | Adis, Springer Healthcare |
| record_format | Article |
| series | Rheumatology and Therapy |
| spelling | doaj.art-25a8d48089224c4788673035a327e06b2023-03-22T12:21:00ZengAdis, Springer HealthcareRheumatology and Therapy2198-65762198-65842023-01-0110242143110.1007/s40744-022-00528-8Number of Attending Physicians and Accumulated Organ Damage in Patients with Systemic Lupus Erythematosus: LUNA Registry Cross-Sectional StudyRyo Yanai0Nobuyuki Yajima1Nao Oguro2Yasuhiro Shimojima3Shigeru Ohno4Hiroshi Kajiyama5Kunihiro Ichinose6Shuzo Sato7Michio Fujiwara8Yoshia Miyawaki9Ryusuke Yoshimi10Takashi Kida11Yusuke Matsuo12Keisuke Nishimura13Ken-ei Sada14Division of Rheumatology, Department of Medicine, Showa University School of MedicineDivision of Rheumatology, Department of Medicine, Showa University School of MedicineDivision of Rheumatology, Department of Medicine, Showa University School of MedicineDepartment of Medicine (Neurology and Rheumatology), Shinshu University School of MedicineCenter for Rheumatic Diseases, Yokohama City University Medical CenterDepartment of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical UniversityDepartment of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical SciencesDepartment of Rheumatology, Fukushima Medical University School of MedicineDepartment of Rheumatology, Yokohama Rosai HospitalDepartment of Nephrology, Rheumatology, Endocrinology, and Metabolism, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of MedicineDepartment of Stem Cell and Immune Regulation, Yokohama City University Graduate School of MedicineInflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of MedicineDepartment of Rheumatology, Tokyo Kyosai HospitalDepartment of Rheumatology and Clinical Immunology, Kobe University Graduate School of MedicineDepartment of Nephrology, Rheumatology, Endocrinology, and Metabolism, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of MedicineAbstract Introduction Patients with systemic lupus erythematosus (SLE) frequently change attending physicians. The number of changes in attending physicians is related to the accumulated organ damage in patients with diabetes mellitus and inflammatory bowel disease, although similar results are not known for patients with SLE. This study investigated whether the number of attending physicians after the onset of SLE is associated with organ damage. Methods Patients with SLE were enrolled in a multicenter registry of 14 institutions (the Lupus Registry of Nationwide Institutions). Patients with a disease duration of 6 months to 10 years were included. Exposure was defined as the number of attending physicians. The primary outcome was the Systemic Lupus International Collaborating Clinics/American College of Rheumatology damage index (SDI). The secondary outcomes were corticosteroid- and non-corticosteroid-related damage. Multiple logistic regression analysis was used to estimate the association between the number of attending physicians and SDI, adjusting for potential confounders, including age, sex, disease duration, number of hospitalizations due to SLE, disease activity at diagnosis, and emotional health. Results Of the 702 patients, 86.5% were women (median age 46 years, interquartile range 35–58). The disease duration was 7.3 years (4.3–11.3), the number of hospitalizations due to SLE was 1 (1–3), the number of attending physicians was 3 (2–4), and SDI was 0 points (0–1). The number of attending physicians was significantly associated with SDI [odds ratio (OR) 1.14, 95% confidence interval (CI) 1.03–1.26]. In the secondary outcome, the number of attending physicians was significantly associated with corticosteroid-related damage (OR 1.22, 95% CI 1.09–1.38). The number of attending physicians was not significantly associated with non-corticosteroid-related damage (OR 1.08, 95% CI 0.99–1.19). Conclusions This study showed that SDI could increase as the number of attending physicians increases. The impact of changing attending physicians warrants greater attention for SLE and other diseases.https://doi.org/10.1007/s40744-022-00528-8Attending physiciansOrgan damageSystemic lupus erythematosusSystemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index |
| spellingShingle | Ryo Yanai Nobuyuki Yajima Nao Oguro Yasuhiro Shimojima Shigeru Ohno Hiroshi Kajiyama Kunihiro Ichinose Shuzo Sato Michio Fujiwara Yoshia Miyawaki Ryusuke Yoshimi Takashi Kida Yusuke Matsuo Keisuke Nishimura Ken-ei Sada Number of Attending Physicians and Accumulated Organ Damage in Patients with Systemic Lupus Erythematosus: LUNA Registry Cross-Sectional Study Rheumatology and Therapy Attending physicians Organ damage Systemic lupus erythematosus Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index |
| title | Number of Attending Physicians and Accumulated Organ Damage in Patients with Systemic Lupus Erythematosus: LUNA Registry Cross-Sectional Study |
| title_full | Number of Attending Physicians and Accumulated Organ Damage in Patients with Systemic Lupus Erythematosus: LUNA Registry Cross-Sectional Study |
| title_fullStr | Number of Attending Physicians and Accumulated Organ Damage in Patients with Systemic Lupus Erythematosus: LUNA Registry Cross-Sectional Study |
| title_full_unstemmed | Number of Attending Physicians and Accumulated Organ Damage in Patients with Systemic Lupus Erythematosus: LUNA Registry Cross-Sectional Study |
| title_short | Number of Attending Physicians and Accumulated Organ Damage in Patients with Systemic Lupus Erythematosus: LUNA Registry Cross-Sectional Study |
| title_sort | number of attending physicians and accumulated organ damage in patients with systemic lupus erythematosus luna registry cross sectional study |
| topic | Attending physicians Organ damage Systemic lupus erythematosus Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index |
| url | https://doi.org/10.1007/s40744-022-00528-8 |
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