Herp regulates intracellular survival of Mycobacterium tuberculosis H37Ra in macrophages by regulating reactive oxygen species-mediated autophagy

Herp regulates intracellular survival of Mycobacterium tuberculosis H37Ra in macrophages by regulating reactive oxygen species-mediated autophagy

ABSTRACT Novel treatment strategies for tuberculosis (TB), such as host-directed therapeutics, may offer therapeutic options for patients with drug-resistant TB. Endoplasmic reticulum (ER) stress-mediated apoptosis is one of the host defense mechanisms used to remove mycobacteria. It is reported tha...

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Bibliographic Details
Main Authors: Sang-Hun Son, Junghwan Lee, Soo-Na Cho, Ji-Ae Choi, Jaewhan Kim, Tam Doan Nguyen, Seong-Ahn Lee, Doyi Son, Chang-Hwa Song
Format: Article
Language:English
Published: American Society for Microbiology 2023-10-01
Series:mBio
Subjects:
ER stress
Mycobacterium tuberculosis
homocysteine-inducible ER protein with ubiquitin-like domain 1
reactive oxygen species
ER-associated degradation
autophagy
Online Access:https://journals.asm.org/doi/10.1128/mbio.01535-23

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