Lung abscess by Fusobacterium nucleatum and Streptococcus spp. co-infection by mNGS: A case series
The aim of this article was to employ shotgun mNGS for pathogen diagnosis in three patients with lung abscesses. The pleural fluid or bronchoalveolar lavage fluid from patients was sent to traditional culture and the shotgun mNGS test. Laboratory culture tested negative and shotgun mNGS analysis rev...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2023-07-01
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| Series: | Open Life Sciences |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/biol-2022-0651 |
| _version_ | 1797773458863554560 |
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| author | Wang Na Gao Zhichao He Shuai Han Mengzhen Han Wenjie Liu Xiaolin Cao Hui Jing Mingxi Sun Tao Xu Junnan |
| author_facet | Wang Na Gao Zhichao He Shuai Han Mengzhen Han Wenjie Liu Xiaolin Cao Hui Jing Mingxi Sun Tao Xu Junnan |
| author_sort | Wang Na |
| collection | DOAJ |
| description | The aim of this article was to employ shotgun mNGS for pathogen diagnosis in three patients with lung abscesses. The pleural fluid or bronchoalveolar lavage fluid from patients was sent to traditional culture and the shotgun mNGS test. Laboratory culture tested negative and shotgun mNGS analysis revealed a co-infection caused by Fusobacterium nucleatum and Streptococcus spp. After standard treatment of co-infection, patients gradually improved and were discharged. This figure is drawn by Figdraw. |
| first_indexed | 2024-03-12T22:06:49Z |
| format | Article |
| id | doaj.art-25a9b7df4bf2446184060579f8a21e0c |
| institution | Directory Open Access Journal |
| issn | 2391-5412 |
| language | English |
| last_indexed | 2024-03-12T22:06:49Z |
| publishDate | 2023-07-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Life Sciences |
| spelling | doaj.art-25a9b7df4bf2446184060579f8a21e0c2023-07-24T11:18:21ZengDe GruyterOpen Life Sciences2391-54122023-07-011811832110.1515/biol-2022-0651Lung abscess by Fusobacterium nucleatum and Streptococcus spp. co-infection by mNGS: A case seriesWang Na0Gao Zhichao1He Shuai2Han Mengzhen3Han Wenjie4Liu Xiaolin5Cao Hui6Jing Mingxi7Sun Tao8Xu Junnan9Department of Breast Medicine, Cancer Hospital of China Medical University, Liaoning Cancer Hospital, Shenyang, 110042, ChinaDepartment of Breast Medicine, Cancer Hospital of China Medical University, Liaoning Cancer Hospital, Shenyang, 110042, ChinaDepartment of Imaging, Cancer Hospital of Dalian University of Technology, Liaoning Cancer Hospital, Shenyang, 110042, ChinaDepartment of Breast Medicine, Cancer Hospital of China Medical University, Liaoning Cancer Hospital, Shenyang, 110042, ChinaDepartment of Breast Medicine, Cancer Hospital of China Medical University, Liaoning Cancer Hospital, Shenyang, 110042, ChinaLiaoning Kanghui Biotechnology Co., Ltd, Zhihuier Street, Hunnan District, Shenyang, 110001, ChinaDepartment of Breast Medicine, Cancer Hospital of China Medical University, Liaoning Cancer Hospital, Shenyang, 110042, ChinaDepartment of Breast Medicine, Cancer Hospital of China Medical University, Liaoning Cancer Hospital, Shenyang, 110042, ChinaDepartment of Breast Medicine, Cancer Hospital of China Medical University, Liaoning Cancer Hospital, Shenyang, 110042, ChinaDepartment of Breast Medicine, Cancer Hospital of China Medical University, Liaoning Cancer Hospital, Shenyang, 110042, ChinaThe aim of this article was to employ shotgun mNGS for pathogen diagnosis in three patients with lung abscesses. The pleural fluid or bronchoalveolar lavage fluid from patients was sent to traditional culture and the shotgun mNGS test. Laboratory culture tested negative and shotgun mNGS analysis revealed a co-infection caused by Fusobacterium nucleatum and Streptococcus spp. After standard treatment of co-infection, patients gradually improved and were discharged. This figure is drawn by Figdraw.https://doi.org/10.1515/biol-2022-0651co-infectionfusobacterium nucleatumlung abscessshotgun metagenome next-generation sequencingstreptococcus spp. |
| spellingShingle | Wang Na Gao Zhichao He Shuai Han Mengzhen Han Wenjie Liu Xiaolin Cao Hui Jing Mingxi Sun Tao Xu Junnan Lung abscess by Fusobacterium nucleatum and Streptococcus spp. co-infection by mNGS: A case series Open Life Sciences co-infection fusobacterium nucleatum lung abscess shotgun metagenome next-generation sequencing streptococcus spp. |
| title | Lung abscess by Fusobacterium nucleatum and Streptococcus spp. co-infection by mNGS: A case series |
| title_full | Lung abscess by Fusobacterium nucleatum and Streptococcus spp. co-infection by mNGS: A case series |
| title_fullStr | Lung abscess by Fusobacterium nucleatum and Streptococcus spp. co-infection by mNGS: A case series |
| title_full_unstemmed | Lung abscess by Fusobacterium nucleatum and Streptococcus spp. co-infection by mNGS: A case series |
| title_short | Lung abscess by Fusobacterium nucleatum and Streptococcus spp. co-infection by mNGS: A case series |
| title_sort | lung abscess by fusobacterium nucleatum and streptococcus spp co infection by mngs a case series |
| topic | co-infection fusobacterium nucleatum lung abscess shotgun metagenome next-generation sequencing streptococcus spp. |
| url | https://doi.org/10.1515/biol-2022-0651 |
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