Effects of dopamine and serotonin antagonist injections into the striatopallidal complex of asymptomatic MPTP-treated monkeys

Effects of dopamine and serotonin antagonist injections into the striatopallidal complex of asymptomatic MPTP-treated monkeys

The cardinal symptoms of Parkinson's disease (PD), akinesia, rigidity and tremor, are only observed when the striatal level of dopamine (DA) is decreased by 60–80%. It is likely that compensatory mechanisms during the early phase of DA depletion delay the appearance of motor symptoms. In a prev...

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Main Authors: Sara Neumane, Stéphanie Mounayar, Caroline Jan, Justine Epinat, Bénédicte Ballanger, Nicolas Costes, Jean Féger, Stéphane Thobois, Chantal François, Véronique Sgambato-Faure, Léon Tremblay
Format: Article
Language:English
Published: Elsevier 2012-10-01
Series:Neurobiology of Disease
Subjects:
Parkinson's disease
Primate
MPTP
Dopamine
Serotonin
Compensatory mechanism
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996112002100

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