Effects of Lysine <i>N</i>-ζ-Methylation in Ultrashort Tetrabasic Lipopeptides (UTBLPs) on the Potentiation of Rifampicin, Novobiocin, and Niclosamide in Gram-Negative Bacteria

Effects of Lysine <i>N</i>-ζ-Methylation in Ultrashort Tetrabasic Lipopeptides (UTBLPs) on the Potentiation of Rifampicin, Novobiocin, and Niclosamide in Gram-Negative Bacteria

Outer membrane (OM) drug impermeability typically associated with a molecular weight above 600 Da and high hydrophobicity prevents accumulation of many antibiotics in Gram-negative bacteria (GNB). Previous studies have shown that ultrashort tetrabasic lipopeptides (UTBLPs) containing multiple lysine...

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Bibliographic Details
Main Authors: Linus Schweizer, Danyel Ramirez, Frank Schweizer
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Antibiotics
Subjects:
outer membrane permeabilizer
antibiotic potentiator
antibiotic adjuvant
novobiocin
rifampicin
niclosamide
Online Access:https://www.mdpi.com/2079-6382/11/3/335

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